Navigation Links
Radiation Treatments Made Safer for Cancer Patients
Date:10/21/2009

In mice, scientists say they can protect healthy tissue

WEDNESDAY, Oct. 21 (HealthDay News) -- U.S. researchers say they may have found a way to protect healthy tissue and also increase tumor death when cancer patients undergo radiation therapy.

The key is a biochemical signaling pathway that can influence how radiation exposure affects both healthy and cancerous cells. In experiments with mice, the researchers found that blocking a molecule called thrombospondin-1 from binding to its cell surface receptor (CD47) resulted in nearly total protection for normal tissue when exposed to standard and very high doses of radiation.

"We almost couldn't believe what we were seeing," study co-author Dr. Jeff S. Isenberg, an associate professor in the division of pulmonary, allergy and critical care medicine at the University of Pittsburgh School of Medicine, said in a news release.

"This dramatic protective effect occurred in skin, muscle and bone marrow cells, which is very encouraging. Cells that might have died of radiation exposure remained viable and functional when pre-treated with agents that interfere with the thrombospondin-1/CD47 pathway," Isenberg said.

The researchers also found that blocking this pathway delayed the regrowth of tumor cells after radiation exposure.

The findings were published Oct. 21 in the journal Science Translational Medicine.

Isenberg and colleagues are investigating the pathway's role in several other conditions, including hypertension, sickle cell disease, heart attack and wound healing.

More information

The American Cancer Society has more about radiation therapy.



-- Robert Preidt



SOURCE: University of Pittsburgh, news release, Oct. 21, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Radiation costs vary widely by delivery, U-M study finds
2. Focused Radiation Protects Tumor Patients Brain Function
3. Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery
4. Radiologists find a technique to significantly reduce patient radiation dose during CT angiography
5. Space-related radiation research could help reduce fractures in cancer survivors
6. Space-Related Radiation Research Could Help Reduce Fractures in Cancer Survivors
7. Particle Beam Radiation Therapy Promising But Unproven for Treating Cancer
8. Worldwide Petition for Motorcycle Cancer Risk ELF EMF Radiation Safety
9. FDA Clears Hologics MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer
10. Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish
11. Varian Medical Systems Adds RapidArc(R) and Image Guidance to New Low Energy Treatment Platform for Radiation Therapy in International Cancer Clinics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... , ... June 24, 2017 , ... The weather is ... time outdoors. Home and business owners should be aware that the summer months provide ... In fact, mechanical locks and keys can be negatively affected from direct exposure to ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode ... of Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers ... RIQI’s Care Management Alerts and Dashboards provide near real-time data about patients admitted ...
(Date:6/23/2017)... ... June 23, 2017 , ... By scoring 100% for fiscal management and accountability, ... premier online charity evaluator, Charity Navigator, validating ANRF's work as a top charity in ... by Charity Navigator and earns ANRF a spot on their “ 10 Charities Worth ...
(Date:6/23/2017)... ... ... Studies show evidence that carotenoids and antioxidants derived either from the diet ... , But how often do ophthalmologists and optometrists in Sweden recommend the use of ... with early symptoms of AMD? A study published recently in Dove Medical ...
(Date:6/23/2017)... ... June 23, 2017 , ... Dr. Ran Y. Rubinstein ... recently begun offering three new minimally invasive procedures to patients who want a ... downtime, Dr. Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 2017  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, ... Iowa location. The ... features an ISO 7 cleanroom—the standard needed to compound intravenous (IV) ... level of pollutants. "Our new ... better serve our Iowa patients," said ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings ... Veterinarian Recommended Solutions (VRS), and KD Pharma Group have ... Nutriceutical Holdings by KD Pharma Group. KD Pharma Group ... the option to acquire the entire company. ... KD. They are committed to growing the NH companies ...
(Date:5/26/2017)... 26, 2017  Endo International plc (NASDAQ: ENDP ... CEO, will represent the Company in a fireside chat at ... Tuesday, June 13, 2017 at 10:40 a.m. PT / 1:40 ... in Rancho Palos Verdes, CA. ... will be available on the Company,s website at http://www.endo.com/investors/overview ...
Breaking Medicine Technology: