Navigation Links
Radiation May Help When Prostate Cancer Returns
Date:6/17/2008

It halved the death rate and might need to be used more often, researchers say

TUESDAY, June 17 (HealthDay News) -- Countering common medical theory, a new study finds that radiation therapy may save the lives of many men whose prostate cancer recurs aggressively after surgery.

"We show that even men with aggressive disease that recurs after surgery seem to benefit from salvage radiotherapy," said lead researcher Bruce J. Trock, associate professor of urology at Johns Hopkins University in Baltimore. "In the past, surgeons would have said that the tumor had spread to other parts of the body and that salvage radiotherapy was not appropriate," he noted.

The belief was that radiation therapy would not help, because it was aimed only at the original tumor site.

But the study of 635 men who had surgery for prostate cancer and then showed signs of recurrence found that the death rate for those who got radiation therapy was half that of men who didn't.

The study, published in the June 18 issue of the Journal of the American Medical Association, was relatively small and needs confirmation, Trock said. "But if it is true, it suggests that more men have recurrence at the local site than has been suspected in the past," he said.

The benefit was greatest for those men with aggressive cancers -- patients whose blood levels of prostate-specific antigen (PSA), a marker for disease activity, doubled in less than six months. Among the 126 men in the study with aggressive disease, the death rate was 75 percent lower for those given salvage radiotherapy versus those who didn't get the treatment.

Over a follow-up period averaging six years after recurrence, death rates were 11 percent for those who had salvage therapy alone, 12 percent for those who got radiation plus hormonal therapy, and 22 percent for men who had no salvage radiation therapy.

The study was called "a very important contribution to our further knowledge about salvation radiotherapy after recurrence" by Dr. Michael J. Zelefsky, professor of radiation oncology at Memorial Sloan-Kettering Cancer Center in New York City.

"It makes two very important points," Zelefsky said. "One is that in order to achieve optimal results, you have to give salvation radiotherapy sooner rather than later, before two years have elapsed. After two years, the results are less optimal.

"Second, the surprising thing to come out of the study is about people who have rapid PSA doubling time. Normally, you think of those patients as having more aggressive disease that has spread elsewhere. This suggests otherwise, that even though the doubling time is more rapid, you still get excellent outcomes with radiotherapy."

Cancer specialists might have to start thinking differently about such cases, Zelefsky said. "People usually have a fatalistic approach when it comes to those patients who present with recurrence and a rapid PSA doubling time," he said. "Now, you might be able to cure them."

It is hard to say whether the report will have an immediate impact on medical practice, both Trock and Zelefsky said. "The study needs to be validated in a formal, randomized controlled trial," Zelefsky said.

But such a study might be beyond the capability of an individual cancer center, Trock said. "You would need at least one or more large institutions with large data bases to validate our results," he said.

More information

Facts on the incidence and treatment of prostate cancer are available from the National Cancer Institute.



SOURCES: Bruce J. Trock, Ph.D., associate professor, urology, Johns Hopkins University, Baltimore; Michael J. Zelefsky, M.D., professor, radiation oncology, Memorial Sloan-Kettering Cancer Center, New York; June 18, 2008, Journal of the American Medical Association


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Informational handout key to giving parents a better understanding of CT radiation risks
2. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
3. Different method of evaluating the urinary tract system reduces radiation dose
4. Radiation and drug combo helps boost efficacy of lung cancer treatment
5. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
6. Radiation therapy technique reduces length of prostate cancer treatment
7. Radiation therapy technique reduces length of prostate cancer treatment
8. Jefferson radiation oncologists use real-time system to plant seeds against cancer
9. Radiation Therapy Services Acquires North Carolina Facility
10. NASA, NSBRI Select 17 Proposals in Space Radiation Research
11. Breast Cancer Radiation Wont Hurt Immune Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Radiation May Help When Prostate Cancer Returns
(Date:3/23/2017)... , ... March 23, 2017 , ... ... Disease Management Accreditation from the NCQA. The accreditation covers StayWell’s asthma, coronary artery ... Accredited status is granted to organizations that have excellent programs for the delivery ...
(Date:3/23/2017)... ... ... The TouchPoint Solution, home of Buzzies *, is boosting the Arizona ... “Buzzies change the way we interact with stress and live our day-to-day lives,” said ... in December 2016, The TouchPoint Solution has sold more than $750,000 in product sales. ...
(Date:3/23/2017)... City (PRWEB) , ... March 23, 2017 , ... After ... fall, FaceCradle , the most-funded travel pillow in crowdfunding history, has ... delivery of its wildly popular travel innovation to Americans. , “We’re excited to be ...
(Date:3/23/2017)... ... March 23, 2017 , ... ChenMed, a privately ... completion of the strategic executive team expansion needed to further optimize growth and ... executive team,” says Christopher Chen, MD, ChenMed Chief Executive Officer. “George Wheeler ...
(Date:3/23/2017)... ... March 23, 2017 , ... Natural Subsistence, a ... of people’s health and nutrition, announced its product Leyzene is now available for ... develops nutritional supplements that help people improve all aspects of their health so ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 AbbVie, a global ... Award-winning choreographer Julianne Hough is helping to ... in the Know about ME in EndoMEtriosis . " ... inspiring women to learn about and understand endometriosis, a ... and to address their symptoms with a healthcare ...
(Date:3/23/2017)... MONICA, Calif. , March 23, 2017   ... launch of a native mobile app for the iPhone. ... standard for surgery coordination and communication for physician offices, ... a native mobile app offers iPhone users even faster, ... "Casetabs is making it even easier to connect care ...
(Date:3/23/2017)... , March 23, 2017 The ... value of USD 25.7 billion by 2025, according to a ... expected to grow at a faster rate due to rising ... awareness about various types of esthetic procedures used for treating ... disorders. Hence, they are considered as the highest revenue generators ...
Breaking Medicine Technology: