Navigation Links
Racial disparity observed in varus and valgus thrust study of knee OA
Date:4/28/2010

A recent study determined that African-Americans were less likely to have a varus thrust, but more likely to have valgus thrust than Caucasians. Varus thrust is visualized during gait as the worsening or abrupt onset of varus (bow-legged) alignment as the leg accepts weight, with a return to less varus and more neutral alignment during lift-off of the foot and the swing phase of gait. Prior research has shown that varus thrust seen in gait is associated with a 4-fold increase in the risk of progression of knee osteoarthritis (OA). Disparity in thrust presence between the races may help explain differences in the pattern of osteoarthritic involvement at the knee. Study findings are published in the May issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.

OA is the most common type of arthritis, characterized by cartilage damage and loss, and causing pain, inflammation, and loss of joint motion. According to The National Institute of Arthritis and Musculoskeletal and Skin Diseases, roughly 27 million Americans 25 years and older have OA. With the aging population, experts project that by 2030 20% of Americans (72 million) will be at risk for developing this disabling disease.

In the current study, a team of researchers from the Feinberg School of Medicine at Northwestern University assessed frequency of varus and valgus thrust in African-Americans and Caucasians and identified factors associated with thrust presence in members of the Osteoarthritis Initiative (OAI) cohort. The OAI thrust study included 3,592 persons (594 African-Americans and 2,998 Caucasians) who were split into two groups: participants without knee OA (n=1,566) and those with OA in one or both knees (n=2026). Those participants without knee OA had a mean age 61 years, a mean body mass index (BMI) of 27.6 kg/m2, and 58.7% were women. In persons with knee OA, the mean age was 63.4 years, the mean BMI was 28.4 kg/m2, and 57.5% were women.

The study revealed that 32.1% of subjects without OA and 36.7% of those with OA had a varus thrust. Valgus thrust was less frequent: 7.2% without OA and 9.1% with OA. The odds of varus thrust were significantly less for African-Americans compared to Caucasians in both disease subgroups, after controlling for other factors. Other factors associated with varus thrust presence in persons without knee OA were age, BMI, varus malalignment, gender (reduced odds in women), and knee extensor strength (reduced odds with greater strength), and, in persons with knee OA, more severe OA disease, varus malalignment, and gender (reduced odds in women).

The odds of valgus thrust were significantly greater for African-Americans compared with Caucasians, in persons without and with knee OA. Also associated with valgus thrust presence in persons without knee OA were valgus malalignment and, in persons with knee OA, more severe lateral disease and valgus malalignment.

"To our knowledge, this is the first report on the frequency of varus and valgus thrust in African-Americans and Caucasians either in persons with or at higher risk of developing knee OA," Dr. Sharma commented. "Further investigation of methods to quantify the elements of a thrust, such as its force and loading rate, will enhance understanding of the mechanism of a thrust effect," concluded the authors. The researchers also caution that persons without knee OA in the OAI thrust study were at high risk of developing it, and thus frequency estimates should not be applied to the general population.


'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. American Human Development Project Releases 'A Century Apart,' Revealing Alarming Disparities in Well-Being Among U.S. Racial and Ethnic Groups
2. Kids With Rare Condition Lack Racial Prejudice
3. Racial Disparities Persist in Hospital Stroke Care
4. Society for New Communications Research Receives Grant to Help Raise Awareness and Reduce Racial and Ethnic Health Disparities
5. Racial disparities diminish in specialized cancer centers
6. Blacks have highest cancer rates of all racial ethnicities, yet feel less at risk, study finds
7. Survey finds significant racial differences in lung cancer beliefs
8. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
9. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
10. Study finds racial gaps continue in heart disease awareness
11. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
Breaking Medicine Technology: