Navigation Links
Racial difference in blood clotting warrants a closer look at heart attack medications
Date:11/10/2013

rmation of a platelet plug that clogs blood vessels and can lead to heart attack or stroke. However, there is considerable variability in how patients respond to these medications, which confounds physicians who must deduce the appropriate drug and proper dose for each patient. Now, researchers from Thomas Jefferson University have identified some of the genetic differences behind these variations, which could help doctors treat racial groups with a more personalized and effective approach.

"Differences in platelet biology could be part of the explanation of the disparity," says Dr. Bray.

To investigate whether the variation among different individuals had a racial component, Dr. Bray and collaborators from Baylor Medical College, Harvard Medical School and the New York and Puget Sound Blood Centers analyzed platelets from blood samples of 154 young healthy subjects that included 70 blacks and 84 whites. Self-reported race was confirmed with genetic tests that verified geographic (African or European) ancestry. Unexpectedly, the researchers found that platelets from black donors clotted faster and to a greater extent in response to the naturally occurring clotting agent, thrombin that specifically triggered one of the platelet-activating receptors, called PAR4. No racial differences were seen with other clotting agents.

Thrombin is the most potent platelet activator in the body, and it is targeted for suppression by numerous blood-thinning medications. However, newer drugs that target thrombin inhibit specific members of the PAR family of receptors. For example, the drug vorapaxar, currently in development for patients with a history of heart disease, specifically inhibits the PAR1 receptor. If PAR1 is blocked by vorapaxar, then PAR4 is the only means by which thrombin can activate platelets, and the Jefferson scientists showed that in this setting thrombin more potently activated platelets from blacks. It remains to be determined how o
'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UC Irvine study finds racial, economic disparities in ovarian cancer care, survival
2. Racial make-up of community impacts obesity risk
3. Racial Gap in Kids Dental Care Vanishing: Study
4. Multiracial youths show similar vulnerability to peer pressure as whites
5. New CDC study on racial disparities in infant mortality published in Journal of Womens Health
6. Black gay men worldwide 15 times more likely to have HIV and racial disparity
7. Racial differences in diabetes diagnostic thresholds
8. Vanderbilt-led study reveals racial disparities in prostate cancer care
9. CT depicts racial differences in coronary artery disease
10. Are there racial disparities in osteoporosis screening and treatment?
11. Racial Disparities Still Seen in Use of Breast Cancer Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... -- Your brain structure could help predict how willing you ... Researchers at Yale University found those with greater volume in ... may be more likely to engage in risky behavior than ... study, funded by the U.S. National Institute on Aging, involved ... the Northeast. The researchers sought to determine how brain structure ...
(Date:9/19/2014)... September 19, 2014 The Alliance ... partnership with the National Fire Protection Association (NFPA), ... collaboration, formalized today in a Memorandum of Understanding ... factories, workers and other stakeholders with information, guidance ... protect the health and safety of workers in ...
(Date:9/19/2014)... In partnership with Raw Beauty NYC, OC ... the project’s social media efforts. StudioPMG is honored to be ... perception of beauty as it applies to disabled women. ... Shelly Baer and Vanessa Silberman, who wanted to create a ... Ginny Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen later ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Famous Vancouver ... announced that it has now become a one-stop-solution for ... and businesses in Vancouver. The company has achieved this ... services to its customers. While there are many companies ... to have a single vendor who can offer all ...
(Date:9/19/2014)... WASHINGTON (Sept. 19, 2014) Shahram Majidi, M.D., ... at the George Washington University School of Medicine ... the American Heart Association to study the presence ... with intracerebral hemorrhage (ICH). , "According to epidemiological ... percent of all strokes, but is the least ...
Breaking Medicine News(10 mins):Health News:Brain Structure Might Help Predict Risky Behavior 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:Pro Ace Now Provides Heating, Air Conditioning, Plumbing & Electrical Services under One Roof 2Health News:GW researcher receives grant to study brain swelling following bleeding in the brain 2
... Medical Students’ Association (AMSA) is hosting the 56th General ... (IFMSA).// ,Medical students from 70 different countries ... commencement of the biannual conference. AMSA is honoured to ... in Santiago, Chile. ,Representing two million ...
... Kelly Perkins is on top of the world, literally. ... of mountaineering feats, as she scaled another mountain peak,// this time ... Heart”. She led her team up one of several unnamed peaks ... Chile, more than 650 miles west of Buenos Aires. ...
... new smoking ban to hit the nation-and one that's aimed// at ... will be allowed to light up only during the final performance ... Actors union, is unfair. Says spokes man Martin McGrath: 'We ... to rehearse properly with any prop, including a cigarette.' He adds ...
... a child's brain, say researchers at the Stanford University ... researchers found that children with post-traumatic stress disorder and ... to experience a decrease in the size of the ... and emotion. ,Although similar effects have been ...
... dreams of - even achieving the //perfect putt on golf links. ... meditates and does yoga for concentration," says Ajay Kumar, director of ... Spa, Kathmandu's pride and one of South Asia's finest golf resorts. ... help golfers hone their concentration - at a price - the ...
... be granted a provisional safety rating until their ... wider //population, experts have said in the latest ... with Vioxx and some other prescription medicines, which ... shown that reliance on pre-marketing trials and voluntary ...
Cached Medicine News:Health News:Severe PTSD Damages Children's Brains: Study 2Health News:Severe PTSD Damages Children's Brains: Study 3Health News:Nepal to Introduce Art of Living for Golfers 2Health News:Time to Overhaul Australia's Medicines Safety Surveillance System 2
(Date:9/19/2014)... , September 19, 2014 ... Market by Equipment (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture ... Users (Hospitals), Advanced technologies - Global Forecast to ... is poised to reach $19,786.3 Million by 2019 ... of 6.8% from 2014 to 2019. ...
(Date:9/19/2014)... , Sept. 19, 2014 Merck (NYSE: MRK ... and Canada , is teaming with celebrity ... Diabetes: Logra Tus Metas , an educational program encouraging Hispanics with ... -- a key treatment goal to help reduce the risk of ... are at a higher risk for developing type 2 diabetes ...
(Date:9/19/2014)... WOONSOCKET, R.I. , Sept. 19, 2014 Five MinuteClinic ... Memphis metropolitan area. Three clinics opened in ... earlier this month. A fourth clinic will be added in ... in Bartlett is expected to open October ... medical clinics in the United States . ...
Breaking Medicine Technology:Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3
... Hana,Biosciences (Nasdaq: HNAB ) today announced ... a planned, pre-specified safety review of interim,data from ... (vincristine,sulfate liposomes injection) for the treatment of adult ... results of the IDMC review continue to,support the ...
... Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium ... today positive preliminary results from its Phase II ... prednisone (D/P) in men with docetaxel refractory, castrate ... of Clinical Oncology (ASCO) Genitourinary Cancers Symposium in ...
Cached Medicine Technology:Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound 2Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound 3Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound 4Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound 5Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer 2Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer 3Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer 4
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
Medicine Products: