Navigation Links
Racial and ethnic differences in the biology of breast cancer tumors
Date:11/29/2007

ATLANTA Scientists from the National Cancer Institute are looking into the racial and ethnic differences in the biology of breast cancer tumors and are presenting their findings this week at the American Association for Cancer Research conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, being held November 27-30 in Atlanta.

While observed differences in breast cancer survival between African-American and Caucasian women are often attributed to disparities in socio-demographic and access to healthcare factors, recent studies have shown that, even when accounting for these factors, African-American women still fare worse than Caucasian women. In a study of how genes are activated in breast cancer tumors, researchers at the National Cancer Institute (NCI) have demonstrated that there are discernable racial and ethnic differences in the biology of these tumors.

In particular, their findings revealed that many genes related to tumor immunobiology, inflammation, and angiogenesis are expressed differently in tumors from African-American women than in those from Caucasian women. The data could indicate that inflammation and other immune system processes play a stronger role in the development and progression of cancer in African-American women, says Damali Martin, Ph.D., postdoctoral fellow at NCIs Center for Cancer Research.

According to Martin, African-American breast cancer patients on the whole tend to have a greater prevalence of a more aggressive form of breast cancer, one that is less likely to respond to hormone therapy and more likely to spread to lymph nodes.

Martin and her colleagues examined gene expression profiles an indicator of which genes are active -- in microdissected breast tumors from 35 patients with invasive breast cancer, including 18 African Americans and 17 Caucasians.

The researchers identified racial discrepancies in the gene profiles that point to significant differences in several biological pathways, including how tumor cells interact with the immune system and the mechanisms for angiogenesis the development of blood vessels that feed tumors. The researchers point out that many of these genes are also active in inflammatory diseases. Previous research has shown a link between inflammatory diseases, such as chronic cholitis, and cancer, Martin says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Mailman School of Public Health study examines link between racial discrimination and substance use
2. Can racial health disparities be effectively reduced?
3. Racial and ethnic differences in colorectal cancer emphasize importance of screening
4. No racial differences seen in outcomes after liver transplantation
5. Genetic differences point to ethnic and racial disparities in colorectal cancer risk
6. Study examines ethnic differences in sleep quality and blood pressure
7. Attitudes toward mammography differ across ethnicities, cultures, backgrounds
8. Survival differences by race most apparent in advanced stages of breast cancer
9. Gene Studies of Male-Female Differences Often Flawed
10. Major differences revealed in how local authorities in the UK support disabled people
11. Differences observed between black and white women in use of breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... CA (PRWEB) , ... September 22, 2017 , ... ... to help you brush more effectively even on the go. Their electric toothbrushes ... gingivitis and gum inflammation, with UV sanitizing technology. Combining leading edge Enke technology ...
(Date:9/22/2017)... ... September 22, 2017 , ... Global Lyme Alliance ... research, education and awareness, today announced the appointment of Timothy J. Sellati, Ph.D. ... Sellati has more than 20 years of research experience with Lyme and other ...
(Date:9/21/2017)... ... 21, 2017 , ... The American Addiction Treatment Association (AATA) ... in the addiction treatment industry entitled: Special Investigations Unit (SIU) – What ... state and federal governments are increasingly scrutinizing the addiction treatment industry for fraudulent ...
(Date:9/21/2017)... ... , ... In addition to sticking with the new years ... and use natural alternatives for all house cleaning products, disinfectants, respiratory relief, and ... the new line of essential oils, are all 100% organic and natural. , ...
(Date:9/21/2017)... RICHMOND, Va. (PRWEB) , ... September 21, 2017 ... ... Richmond with a different approach to addiction recovery at a time when Virginia ... 1,420 deaths resulting from drug overdose, a staggering increase of 38 percent from ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)...  Medical professionals are expected to continuously ... their patients. Medical simulations offer clinicians the ... Simulation provides a safe method for teaching ... refine techniques and build confidence, without putting ... such as augmented reality, will now provide ...
(Date:9/5/2017)... 5, 2017  Xyntek Inc. has announced another milestone in their continued growth ... to meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams Street, Suite ... Xyntek's ... ...
(Date:9/1/2017)... , Sept. 1, 2017  Explorers Like Us ( https://explorerslikeus.com/ ... greatest aural experiences — and deliver these experiences as part ... help people feel and heal better. ... While nothing beats a walk, jog ... your mind, Life Environments™ is the next best thing when ...
Breaking Medicine Technology: