Navigation Links
Racial and ethnic differences in the biology of breast cancer tumors
Date:11/29/2007

ATLANTA Scientists from the National Cancer Institute are looking into the racial and ethnic differences in the biology of breast cancer tumors and are presenting their findings this week at the American Association for Cancer Research conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, being held November 27-30 in Atlanta.

While observed differences in breast cancer survival between African-American and Caucasian women are often attributed to disparities in socio-demographic and access to healthcare factors, recent studies have shown that, even when accounting for these factors, African-American women still fare worse than Caucasian women. In a study of how genes are activated in breast cancer tumors, researchers at the National Cancer Institute (NCI) have demonstrated that there are discernable racial and ethnic differences in the biology of these tumors.

In particular, their findings revealed that many genes related to tumor immunobiology, inflammation, and angiogenesis are expressed differently in tumors from African-American women than in those from Caucasian women. The data could indicate that inflammation and other immune system processes play a stronger role in the development and progression of cancer in African-American women, says Damali Martin, Ph.D., postdoctoral fellow at NCIs Center for Cancer Research.

According to Martin, African-American breast cancer patients on the whole tend to have a greater prevalence of a more aggressive form of breast cancer, one that is less likely to respond to hormone therapy and more likely to spread to lymph nodes.

Martin and her colleagues examined gene expression profiles an indicator of which genes are active -- in microdissected breast tumors from 35 patients with invasive breast cancer, including 18 African Americans and 17 Caucasians.

The researchers identified racial discrepancies in the gene profiles that point to significant differences in several biological pathways, including how tumor cells interact with the immune system and the mechanisms for angiogenesis the development of blood vessels that feed tumors. The researchers point out that many of these genes are also active in inflammatory diseases. Previous research has shown a link between inflammatory diseases, such as chronic cholitis, and cancer, Martin says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Mailman School of Public Health study examines link between racial discrimination and substance use
2. Can racial health disparities be effectively reduced?
3. Racial and ethnic differences in colorectal cancer emphasize importance of screening
4. No racial differences seen in outcomes after liver transplantation
5. Genetic differences point to ethnic and racial disparities in colorectal cancer risk
6. Study examines ethnic differences in sleep quality and blood pressure
7. Attitudes toward mammography differ across ethnicities, cultures, backgrounds
8. Survival differences by race most apparent in advanced stages of breast cancer
9. Gene Studies of Male-Female Differences Often Flawed
10. Major differences revealed in how local authorities in the UK support disabled people
11. Differences observed between black and white women in use of breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... ... strategic sales leadership and to further develop their rapidly expanding portfolio of customer ... Administration with a concentration in Marketing and an M.B.A. with concentration in management ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... surgical safety efforts for several years, and the efforts have paid off. ... efforts include new standards of care to enhance perioperative patient experiences and reduce ...
(Date:5/26/2016)... Vegas, NV (PRWEB) , ... May 26, 2016 , ... ... Ergonomic Tools,” identifies the impact of mobile devices on the billions of users, hundreds ... backs and necks. While not life threatening, the frequent and common action of ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... seeking nominations to serve on its Accreditation and Standards Committees and support ... quality-benchmarking activities incorporate key process and outcome measures, with the ultimate mission ...
(Date:5/26/2016)... ... May 26, 2016 , ... In 1980, Bill Howe opened ... throughout the beach community. His vision to grow the company was built on a ... maintain the highest level of training and customer service. Over 35 years later, Bill ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Texas , May 25, 2016 ... the issuance to it by the US Patent ... The company,s technology includes proprietary processes for electronic ... for health and wellness programs, HIPAA compliance and ... "Our technology ...
(Date:5/24/2016)... Cirujanos holandeses han puesto en marcha una ... compartir sus mejores prácticas por el mundo y tratar ... Europa, África, Asia y Estados ... combina la transmisión en vivo con mensajería instantánea y ... "Imagine un médico de Medicines sans Frontieres ...
(Date:5/24/2016)...  NxStage Medical, Inc. (Nasdaq: NXTM ), ... care, today announced that Jeffrey H. Burbank , ... schedule of investor conferences. Where applicable, a webcast of ... .   ... Friday, June 10, 2016 1:30 p.m. ET ...
Breaking Medicine Technology: