Navigation Links
Racial and ethnic differences in the biology of breast cancer tumors
Date:11/29/2007

ATLANTA Scientists from the National Cancer Institute are looking into the racial and ethnic differences in the biology of breast cancer tumors and are presenting their findings this week at the American Association for Cancer Research conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, being held November 27-30 in Atlanta.

While observed differences in breast cancer survival between African-American and Caucasian women are often attributed to disparities in socio-demographic and access to healthcare factors, recent studies have shown that, even when accounting for these factors, African-American women still fare worse than Caucasian women. In a study of how genes are activated in breast cancer tumors, researchers at the National Cancer Institute (NCI) have demonstrated that there are discernable racial and ethnic differences in the biology of these tumors.

In particular, their findings revealed that many genes related to tumor immunobiology, inflammation, and angiogenesis are expressed differently in tumors from African-American women than in those from Caucasian women. The data could indicate that inflammation and other immune system processes play a stronger role in the development and progression of cancer in African-American women, says Damali Martin, Ph.D., postdoctoral fellow at NCIs Center for Cancer Research.

According to Martin, African-American breast cancer patients on the whole tend to have a greater prevalence of a more aggressive form of breast cancer, one that is less likely to respond to hormone therapy and more likely to spread to lymph nodes.

Martin and her colleagues examined gene expression profiles an indicator of which genes are active -- in microdissected breast tumors from 35 patients with invasive breast cancer, including 18 African Americans and 17 Caucasians.

The researchers identified racial discrepancies in the gene profiles that point to significant differences in several biological pathways, including how tumor cells interact with the immune system and the mechanisms for angiogenesis the development of blood vessels that feed tumors. The researchers point out that many of these genes are also active in inflammatory diseases. Previous research has shown a link between inflammatory diseases, such as chronic cholitis, and cancer, Martin says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Mailman School of Public Health study examines link between racial discrimination and substance use
2. Can racial health disparities be effectively reduced?
3. Racial and ethnic differences in colorectal cancer emphasize importance of screening
4. No racial differences seen in outcomes after liver transplantation
5. Genetic differences point to ethnic and racial disparities in colorectal cancer risk
6. Study examines ethnic differences in sleep quality and blood pressure
7. Attitudes toward mammography differ across ethnicities, cultures, backgrounds
8. Survival differences by race most apparent in advanced stages of breast cancer
9. Gene Studies of Male-Female Differences Often Flawed
10. Major differences revealed in how local authorities in the UK support disabled people
11. Differences observed between black and white women in use of breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... Greenfield Insurance Group ... created to assist the people of their local community. The agency pledges to ... community leaders. Their hope is to bring awareness to important local causes with ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... practice Village Family Practice , will be presenting at the 2016 HIMSS ... Las Vegas, Nev. , During his session, “ Coding for Care: Using ...
(Date:2/11/2016)... , ... February 11, 2016 , ... The annual list ... on evaluation of DataPoint’s team dedication and commitment to the SharePoint ecosystem. ... the annual list. The panel’s goal is to recognize and promote technology entrepreneurship. ...
(Date:2/11/2016)... ... February 11, 2016 , ... From March ... Academy of Dermatology Annual Meeting at the Walter E. Washington Convention Center in ... for both the condition of hyperhidrosis (excessive sweating) and its treatment options. Specifically, ...
(Date:2/11/2016)... CO. (PRWEB) , ... February 11, 2016 , ... ... people have become more actively engaged in health and wellness best practices in ... importance of riding this trend. February is American Heart Month, which acts as ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... JOSE, Calif. , Feb. 11, 2016 /PRNewswire/ ... pioneered the use of the iFuse Implant System, ... fusion for certain disorders of the sacroiliac (SI) ... showing the cost benefits of MIS SI joint ... dysfunction due to degenerative sacroiliitis or SI joint ...
(Date:2/11/2016)... 11, 2016  AcelRx Pharmaceuticals, Inc. (NASDAQ: ACRX ... made at the 38th annual John A. Boswick ... which is being held February 14-18, 2016 in ... latest advancements in wound healing, burn care, and infection ... Australian-New Zealand Burns Association, Academy of Physicians in Wound ...
(Date:2/11/2016)... , Feb. 11, 2016  NanoViricides, Inc. (NYSE ... has entered into an agreement with the University ... drug candidates in standard animal models of ocular ... Research Director. Dr. Romanowski has extensive experience in ... --> Eric Romanowski , Research Director. ...
Breaking Medicine Technology: