Navigation Links
Racial and ethnic differences in the biology of breast cancer tumors
Date:11/29/2007

ATLANTA Scientists from the National Cancer Institute are looking into the racial and ethnic differences in the biology of breast cancer tumors and are presenting their findings this week at the American Association for Cancer Research conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, being held November 27-30 in Atlanta.

While observed differences in breast cancer survival between African-American and Caucasian women are often attributed to disparities in socio-demographic and access to healthcare factors, recent studies have shown that, even when accounting for these factors, African-American women still fare worse than Caucasian women. In a study of how genes are activated in breast cancer tumors, researchers at the National Cancer Institute (NCI) have demonstrated that there are discernable racial and ethnic differences in the biology of these tumors.

In particular, their findings revealed that many genes related to tumor immunobiology, inflammation, and angiogenesis are expressed differently in tumors from African-American women than in those from Caucasian women. The data could indicate that inflammation and other immune system processes play a stronger role in the development and progression of cancer in African-American women, says Damali Martin, Ph.D., postdoctoral fellow at NCIs Center for Cancer Research.

According to Martin, African-American breast cancer patients on the whole tend to have a greater prevalence of a more aggressive form of breast cancer, one that is less likely to respond to hormone therapy and more likely to spread to lymph nodes.

Martin and her colleagues examined gene expression profiles an indicator of which genes are active -- in microdissected breast tumors from 35 patients with invasive breast cancer, including 18 African Americans and 17 Caucasians.

The researchers identified racial discrepancies in the gene profiles that point to significant differences in several biological pathways, including how tumor cells interact with the immune system and the mechanisms for angiogenesis the development of blood vessels that feed tumors. The researchers point out that many of these genes are also active in inflammatory diseases. Previous research has shown a link between inflammatory diseases, such as chronic cholitis, and cancer, Martin says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Mailman School of Public Health study examines link between racial discrimination and substance use
2. Can racial health disparities be effectively reduced?
3. Racial and ethnic differences in colorectal cancer emphasize importance of screening
4. No racial differences seen in outcomes after liver transplantation
5. Genetic differences point to ethnic and racial disparities in colorectal cancer risk
6. Study examines ethnic differences in sleep quality and blood pressure
7. Attitudes toward mammography differ across ethnicities, cultures, backgrounds
8. Survival differences by race most apparent in advanced stages of breast cancer
9. Gene Studies of Male-Female Differences Often Flawed
10. Major differences revealed in how local authorities in the UK support disabled people
11. Differences observed between black and white women in use of breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... the University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® ... The program, developed in association with efforts by the American College of Surgeons, ...
(Date:3/28/2017)... ... 2017 , ... The Radiology Business Management Association (RBMA) is pleased ... new executive director. Mr. Still was selected through a careful months-long search by the ... is known to our members, has been a part of building the RBMA since ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Conn., has relocated its corporate headquarters to a new, more expansive office space ... In October 2016, Qualidigm purchased a distressed office building in Wethersfield, Conn. located ...
(Date:3/28/2017)... ... March 28, 2017 , ... METTLER ... ions found in power plant water and steam. , Chlorides and sulfates cause ... boilers, leading to extensive maintenance and unplanned shutdowns. Monitoring these ions at low ...
(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin Harper, Founder ... few medical professionals in the country to sit on the 2017 National Advisory Board ... just 2 years Dr. Harper helped propel the clinic from a small start-up to ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TAIPEI, Taiwan , March 28, 2017 /PRNewswire/ ... medical device company, is pleased to announce ... Series A investment of Panther Orthopedics, Inc., a ... pioneering innovative dynamic fixation solutions for orthopedic extremity ... market continues to expand rapidly, primarily due to ...
(Date:3/27/2017)... -- The National University of Singapore (NUS) and ... signed a Memorandum of Understanding (MOU) recently to ... region. Under this MOU, the ... (BIGHEART) at NUS and Holmusk will establish a ... IT and medical device development. These include personal ...
(Date:3/27/2017)... LONDON , March 27, 2017 ... require to better understand Eli Lilly and its partnering interests ... Alliance since 2010 report provides an in-depth insight into the ... companies. On demand company reports are prepared upon ... deal and company data. The report will be ...
Breaking Medicine Technology: