Navigation Links
Race may influence uterine cancer recurrence, despite treatment
Date:11/1/2010

DETROIT African Americans are more likely to have a recurrence of uterine cancer despite undergoing a total hysterectomy or a hysterectomy followed by radiation therapy, according to researchers at Henry Ford Hospital in Detroit.

"The African American patients in our study had similar surgeries and radiation therapy as the Caucasian patients in the study. So access to care certainly wasn't a factor in race being identified as a negative predictor for outcome," says lead author Mohamed Elshaikh, M.D., senior staff physician in the Department of Radiation Oncology at Henry Ford Hospital.

"At this point, our next step is to take a closer look at the underlying molecular biology of these cancer cells to help identify a cause for race being a negative predictor for uterine cancer outcome."

This retrospective study one of the largest of its kind with 750 uterine cancer patients will be presented Nov. 2 at the 52nd annual American Society for Radiation Oncology (ASTRO) meeting in San Diego. Results also are now online in the November issue of the International Journal of Radiation Oncology.

"What's notable about our study is that we were able to confirm on a larger scale the known prognostic factors in uterine cancer, and also identify African American race as a negative predictor for outcome despite adequate surgery and radiation treatment," says Dr. Elshaikh.

Endometrial cancers mainly arise from the tissue lining the uterus. They are the most common gynecologic cancers in the United States, with more than 43,000 women diagnosed and an estimated 7,950 dying from the disease in 2010, according to the National Cancer Institute. The most common type, endometrioid adenocarcinoma, typically occurs within a few decades of menopause.

While a total hysterectomy (surgical removal of the uterus) is the most common therapeutic approach, treating physicians often differ on the next step for treatment after surgery. Some recommend radiation treatment, while others recommend no further treatment.

For the Henry Ford study, Dr. Elshaikh and his colleagues identified 750 patients with stage I or II uterine cancer who underwent a total hysterectomy between 1987 and 2008. The median age was 64, and 30 percent of the study group were African American.

The study was limited to those patients who underwent surgery and received no further treatment, and those who underwent surgery and had radiation therapy.

Recurrence-free survival for the study group at 5 years and 10 years was 94 percent and 93 percent, respectively.

The median time for uterine cancer recurrence among the group was 1.2 years.

The site of recurrence was primarily vaginal (74 percent) for those who did not receive radiation therapy.

The study also found that higher tumor grade and cancer stage, along with age (older than 65), were risk factors for uterine cancer returning after treatment. African American patients in the study also were more likely to have their cancer return than Caucasian patients.


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. OCTANE study influences revision of WHO guidelines for treating some HIV-infected women
2. Location determines social network influence, CCNY-led team finds
3. Presidential election outcomes directly influence suicide rates
4. Rhetoric, framing efforts have little influence in same-sex marriage debate
5. Winning record, team longevity, prime-time games influence NFL TV ratings
6. Moms Mental State Influenced Kids Well-Being After 9/11: Study
7. Smoking influences gene function, scientists say
8. The Framingham Heart Study -- global impact, ongoing influence
9. PTSD: The serotonin system influences vulnerability and treatment
10. Health Plan May Influence 5-Year Rectal Cancer Survival
11. Strangers influence our dating preferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... 11, 2016 , ... Florida Hospital presents Heart Health Awareness night on Sunday ... at the Amalie Arena. The puck drops at 6:00pm, but fans will have the ... prior to the game. The MEGA Heart will be located on Ford Thunder Alley ...
(Date:2/11/2016)... ... February 11, 2016 , ... The Chartis ... the top five firms in the “2015/2016 Best in KLAS: Software and Services” ... KLAS is a research and insights firm on a global mission to improve ...
(Date:2/11/2016)... ... February 11, 2016 , ... In ... Dallas plastic surgeon , Dr. Rod J. Rohrich, and colleagues, examine and ... Rohrich outlines recommendations for rhinoplasty surgeons when addressing this vital area. , The ...
(Date:2/11/2016)... ... February 11, 2016 , ... "What holds you back ... Clarke poses a question as a challenge for his readers to examine the ... the Being" (published by Partridge Singapore), Clarke explores the subject with more depth, ...
(Date:2/11/2016)... ... February 11, 2016 , ... Colorado spine surgeon, Donald Corenman, MD, DC ... surgeons to know in 2016 . The list consists of spine surgeons across the ... , Dr. Corenman understands the importance of clinical excellence; he has been awarded the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... de fevereiro de 2016  A Proliant Biologicals ... de soroalbumina bovina (BSA -- Bovine Serum ... na Ilha Norte da Nova Zelândia, em Feilding. ... na fábrica da Proliant nos EUA, localizada em ... e instalação dos equipamentos foram feitos de forma ...
(Date:2/11/2016)... Transformational M&A achieved through NPS and Dyax acquisitions and the ... achieved through NPS and Dyax acquisitions and the announced combination ... through NPS and Dyax acquisitions and the announced combination with ... robust pipeline in Shire , s history   ... pipeline in Shire , s history   ...
(Date:2/11/2016)... 2016 Breast Cancer Therapeutics in Asia-Pacific ... Asia-Pacific (APAC) breast cancer market will experience considerable ... 2021, at a Compound Annual Growth Rate (CAGR) of 8.5%. ... 2021 - states that the Asia-Pacific ... $1.9 billion in 2014 to $3.4 billion by 2021, at ...
Breaking Medicine Technology: