Navigation Links
Race may influence uterine cancer recurrence, despite treatment
Date:11/1/2010

DETROIT African Americans are more likely to have a recurrence of uterine cancer despite undergoing a total hysterectomy or a hysterectomy followed by radiation therapy, according to researchers at Henry Ford Hospital in Detroit.

"The African American patients in our study had similar surgeries and radiation therapy as the Caucasian patients in the study. So access to care certainly wasn't a factor in race being identified as a negative predictor for outcome," says lead author Mohamed Elshaikh, M.D., senior staff physician in the Department of Radiation Oncology at Henry Ford Hospital.

"At this point, our next step is to take a closer look at the underlying molecular biology of these cancer cells to help identify a cause for race being a negative predictor for uterine cancer outcome."

This retrospective study one of the largest of its kind with 750 uterine cancer patients will be presented Nov. 2 at the 52nd annual American Society for Radiation Oncology (ASTRO) meeting in San Diego. Results also are now online in the November issue of the International Journal of Radiation Oncology.

"What's notable about our study is that we were able to confirm on a larger scale the known prognostic factors in uterine cancer, and also identify African American race as a negative predictor for outcome despite adequate surgery and radiation treatment," says Dr. Elshaikh.

Endometrial cancers mainly arise from the tissue lining the uterus. They are the most common gynecologic cancers in the United States, with more than 43,000 women diagnosed and an estimated 7,950 dying from the disease in 2010, according to the National Cancer Institute. The most common type, endometrioid adenocarcinoma, typically occurs within a few decades of menopause.

While a total hysterectomy (surgical removal of the uterus) is the most common therapeutic approach, treating physicians often differ on the next step for treatment after surgery. Some recommend radiation treatment, while others recommend no further treatment.

For the Henry Ford study, Dr. Elshaikh and his colleagues identified 750 patients with stage I or II uterine cancer who underwent a total hysterectomy between 1987 and 2008. The median age was 64, and 30 percent of the study group were African American.

The study was limited to those patients who underwent surgery and received no further treatment, and those who underwent surgery and had radiation therapy.

Recurrence-free survival for the study group at 5 years and 10 years was 94 percent and 93 percent, respectively.

The median time for uterine cancer recurrence among the group was 1.2 years.

The site of recurrence was primarily vaginal (74 percent) for those who did not receive radiation therapy.

The study also found that higher tumor grade and cancer stage, along with age (older than 65), were risk factors for uterine cancer returning after treatment. African American patients in the study also were more likely to have their cancer return than Caucasian patients.


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. OCTANE study influences revision of WHO guidelines for treating some HIV-infected women
2. Location determines social network influence, CCNY-led team finds
3. Presidential election outcomes directly influence suicide rates
4. Rhetoric, framing efforts have little influence in same-sex marriage debate
5. Winning record, team longevity, prime-time games influence NFL TV ratings
6. Moms Mental State Influenced Kids Well-Being After 9/11: Study
7. Smoking influences gene function, scientists say
8. The Framingham Heart Study -- global impact, ongoing influence
9. PTSD: The serotonin system influences vulnerability and treatment
10. Health Plan May Influence 5-Year Rectal Cancer Survival
11. Strangers influence our dating preferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... AvePoint ... seventh North American office location in Richmond, Virginia, located at the Riverfront Plaza, 901 ... attended by Lieutenant Governor of Virginia Ralph S. Northam and Mayor of Richmond Levar ...
(Date:3/28/2017)... ... , ... For many women, getting birth control isn’t as easy as it should be. In ... access to a health care facility or a pharmacy within 60 minutes of where they ... or for many who are faced with health or personal issues that leave them homebound. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Revolution for Truth ... Congress to protect parental rights and civil liberties, and to restore transparency within ... The demonstration coincides with a press conference taking place Friday morning calling on ...
(Date:3/28/2017)... ... March 28, 2017 , ... Medforce Technologies, Inc., a ... announce it has joined the National Association for Home Care and Hospice (NAHC), ... disabled, and dying Americans of all ages and the caregiver who provide them ...
(Date:3/28/2017)... ... March 28, 2017 , ... Z-Medica, ... University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® (BCK) ... program, developed in association with efforts by the American College of Surgeons, U.S. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  Maxor National Pharmacy Services, ... that it has named Leah Bailey as ... divisions of the company. With more than ... previous 8 years focused on health care, Bailey joins ... tenure at Prime, Bailey advised the PBM, Specialty, and ...
(Date:3/29/2017)... March 29, 2017  Designers of primary cell wearable ... size by 50% and extend battery life with the ... integrated circuit (PMIC) from Maxim Integrated Products, Inc. (NASDAQ: ... low input voltage of just 0.7V for new high-energy ... Oxide, as well as the more common Alkaline battery ...
(Date:3/29/2017)... , USA, March 29, 2017 Stryker ... that Cares by People magazine, in partnership with Great ... 50 companies on the list. This list highlights the ... have succeeded in business while also demonstrating respect, compassion ... environment.  To determine the companies on ...
Breaking Medicine Technology: