DURHAM, N.C. Obese white men who have both diabetes and prostate cancer have significantly worse outcomes following radical prostatectomy than do men without diabetes who undergo the same procedure, according to research from Duke University Medical Center appearing in Cancer Epidemiology, Biomarkers & Prevention.
Many studies have shown that diabetes is associated with a lower risk of developing prostate cancer -- at least in white men -- but the effect of diabetes on outcomes after prostate cancer surgery has not been as clear.
"We found that diabetes was significantly associated with more aggressive disease in obese white men and less aggressive disease for all other subsets of men in our study," says Stephen Freedland, M.D., associate professor of urology and pathology at the Duke Prostate Center at Duke University and member of the Urology Section, Veterans Affairs Medical Center in Durham.
Researchers have spent years assessing the interplay among race, weight, diabetes and prostate cancer and have come up with mixed results.
Studies have shown that black men are significantly more likely than white men to develop prostate cancer, to have more aggressive disease and to experience a greater likelihood of recurrence.
Diabetes is more prevalent among black adults than white adults (11.8 per cent vs. 7.5 percent, respectively).
Studies show that obesity is also associated with increased risk of aggressive disease, recurrence, and death from prostate cancer and diabetes.
"Given that race and obesity are related to both aggressive prostate cancer and diabetes, we hypothesized that the association between diabetes and prostate cancer progression might vary by race and obesity," says Freedland.
The study, published in Cancer Epidemiology, Biomarkers & Prevention, examined the records of 1,262 men in the SEARCH database who underwent radical prostatectomy between 1988 and
|Contact: Michelle Gailiun|
Duke University Medical Center