Navigation Links
RaDAR guides proteins into the nucleus
Date:5/22/2014

May 22, 2014, New York, NY A Ludwig Cancer Research study has identified a novel pathway by which proteins are actively and specifically shuttled into the nucleus of a cell. Published online today in Cell, the finding captures a precise molecular barcode that flags proteins for such import and describes the biochemical interaction that drives this critically important process. The discovery could help illuminate the molecular dysfunction that underpins a broad array of ailments, ranging from autoimmune diseases to cancers.

Although small proteins can diffuse passively through pores built into the nuclear membrane, most nuclear proteins have to be actively driven into the nucleus through specialized pores to ensure that the cell functions normally. Proteins targeted to specific compartments in cells often carry a sequence of amino acids that, like a barcode, tells components of the cell's transport machinery where they should be located in order to perform their biochemical duties.

"Until now, only one nuclear import pathway for active transport has been extensively characterized," says Xin Lu, Ludwig director at the University of Oxford whose laboratory led the study. "It targets proteins that encode what's known as the nuclear localization signal (NLS). Yet about half of the proteins that get into the nucleus do not bear an NLS, and how they get there has long puzzled researchers. Now we have discovered an alternative signal by which proteins devoid of NLS are tagged for nuclear import." The finding will help scientists better understand the roles many hitherto poorly characterized proteins play in cellular life, and identify many others that work within the nucleus on such tasks as gene regulation and expression.

The researchers were led to their discovery while investigating how an important tumor suppressor protein known as ASPP, which Lu's laboratory has been studying for many years, gets into the nucleus. Their experim
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NewsWatch Recently Featured the “Radarbox24” Mobile Application on National Television
2. Millimeter Wave Market (MM Scanners, MM RADARs, MM Macro/Small Cell Backhaul) Worth $1.2 Billion by 2018 - New Report by MarketsandMarkets
3. MD Anderson guides intelligent redesign of cancer care delivery model
4. Assure A Smile Publishes New Holistic Health Guides for 2014
5. A New “15 Tips To Improve Personality” Article Guides People How to Improve Their Good Personality Easily – V-kool
6. Unique change in protein structure guides production of RNA from DNA
7. Medical SG Launches Singapore Medical Guides
8. MyMEDHoliday.com Unveils New Visa Guides for Medical Tourists Seeking Treatment in Asia
9. Flexibility Training Exercises
10. “Ageless Mobility” Guides People How To Improve Physical Health – Vkoolelite
11. Advanced Medical Certification Offers Audiobooks and PDF Study Guides at No Cost Upon Course Purchase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Boston Children’s Museum and From ... concert series, introducing young Museum visitors to musicians ... premier national platform celebrating the stories, talents, and ... young musicians featured will also be showcased on ... is fortunate to partner with the wonderful musicians ...
(Date:9/17/2014)... 17, 2014 A petition to ban ... laparoscopic hysterectomies and other gynecological surgeries has gathered nearly ... posted on Change.org, at least 84,908 supporters had signed ... to a recent report from ABC News, the Change.org ... Hooman Noorchashm, after his wife, Dr. Amy Reed, was ...
(Date:9/17/2014)... (HealthDay News) -- Present-day Europeans are the descendants ... according to a new study. Previous ... and early European farmers. But, a new genetic ... also the descendants of Ancient North Eurasians. Nearly ... third ancestral group, researchers from Harvard Medical School ...
(Date:9/17/2014)... is not properly designed to meet the needs of ... their families, and major changes to the system are ... Medicine. The 21-member committee that wrote the report ... medical care and social services and that is high-quality, ... "advance care planning" for end-of-life by individuals, for improved ...
(Date:9/17/2014)... 2014 Mercy “topped out” the world’s ... final beam into place. Sister of Mercy Claudia Ward ... (Photos and video of the event, including footage from ... http://bit.ly/MercyVirtual .) , “The topping out means we ... to thousands of patients regardless of the hour or ...
Breaking Medicine News(10 mins):Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 2Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 3Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 4Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 2Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 4Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 5Health News:Mercy Tops Out World's First Virtual Care Center 2
... Flu Granted Conditional License by USDA , ... Health, the global leader in veterinary biologicals, today ... canine influenza virus (CIV), which was granted a ... Department of Agriculture (USDA) on May ...
... ,Kidney Walk, At Soldier Field , , MOUNTAIN VIEW, ... first and leading providers of kidney dialysis services and a ... the National Kidney Foundation (NKF) of Illinois, Kidney Walk in ... will be held Sunday, June 28, 2009 at Soldier Field ...
... , , , Teva Pharmaceuticals Hosting Second ... Campaign , , CHICAGO, June 23 According ... of three people in Illinois under the age of 65 ... awareness to the healthcare issues facing everyday Americans, on June ...
... Philadelphia Opens Free-Standing Inpatient Unit , ... These are the adjectives Hospice of Philadelphia considered when it developed ... patient in their own home is ideal, but is not always ... hospital. The new hospice unit provides patients and their families ...
... and NEW YORK, June 23 The ... the American University of Beirut Medical Center ... The Magnet program recognizes nursing excellence "in the ... services in an environment that supports professional nursing practice, ...
... a new breast biopsy technique that could lead to ... according to a study performed at Roberts Research Institute, ... Centre, London, ON, Canada. The new technique uses a ... and has a braking system to allow for accurate ...
Cached Medicine News:Health News:New Vaccine from Intervet/Schering-Plough Animal Health is First for Canine Influenza Virus 2Health News:New Vaccine from Intervet/Schering-Plough Animal Health is First for Canine Influenza Virus 3Health News:New Vaccine from Intervet/Schering-Plough Animal Health is First for Canine Influenza Virus 4Health News:Satellite Healthcare Supports Kidney Wellness in Chicago 2Health News:Businesses, Community Leaders Invited to Come Together to Examine the Rising Cost of Healthcare 2Health News:Unique Facility Designed for the Comfort of Hospice Patients and Their Families 2Health News:Unique Facility Designed for the Comfort of Hospice Patients and Their Families 3Health News:AUB Medical Center Designated First 'Magnet' Facility in the Middle East 2Health News:AUB Medical Center Designated First 'Magnet' Facility in the Middle East 3
(Date:9/17/2014)... , Sept. 17, 2014 BRIC Biopsy Devices ... GlobalData,s new report, "BRIC Biopsy Devices Market Outlook ... Biopsy Devices market. The report provides value, in millions ... (in US dollars) within market segments - Biopsy Guns ... Fine Aspiration Needles (Disposable and Reusable Fine Aspiration Needles) ...
(Date:9/17/2014)... 17, 2014 The ambulance equipment ... decade due to the recession, an unstable ... advancements. This BCC Research report analyzes present ... the ambulance and emergency medical services equipment ... hemorrhage control devices, equipment used for burn ...
(Date:9/17/2014)... 2014 /PRNewswire-iReach/ -- ChemImage announced today the ... in the development of imaging technology used ... and diseased tissue that minimizes the learning ... lowers surgical costs and potentially enhances patient ... The clinical and scientific teams at ...
Breaking Medicine Technology:BRIC Biopsy Devices Market Outlook to 2020 2BRIC Biopsy Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2
... , , DURHAM, N.C., Jan. 8 Oxygen ... common stock has been approved for listing on the NASDAQ ... to the NASDAQ is a very important milestone for our ... listed on the NASDAQ provides us with greater visibility for ...
... , , , FARMINGDALE, N.Y., Jan. ... of minimally invasive ultrasonic medical device technology, which in Europe ... other acute health conditions, has entered into a new, three ... in Riyadh, Kingdom of Saudi Arabia, for the distribution of ...
Cached Medicine Technology:Oxygen Biotherapeutics, Inc. Announces Approval for NASDAQ Listing 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: