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RTOG initiates a phase I trial testing the therapy ganitumab for locally advanced pancreatic cancer
Date:12/14/2011

ease in toxicity during chemoradiation when induction chemotherapy is first administered.

Following induction chemotherapy, study participants will receive ganitumabfirst investigating doses of 12mg/kg and, if tolerated, subsequently 20 mg/kgalong with standard chemoradiation treatment. Upon treatment completion, participants will continue to receive maintenance doses of gemcitabine and ganitumab until tumor progression.

According to Walter Curran, MD, RTOG Group Chair and Executive Director of the Winship Cancer Institute of Emory University in Atlanta, "Amgen is conducting a phase III trial of ganitumab in metastatic pancreatic cancer. If trial results for treatment of metastatic disease are positive, moving forward with a randomized phase II trial for patients with locally advanced disease would be indicated. In this scenario, the RTOG 1102 trial results will expedite further evaluation of this targeted therapy."


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Contact: Nancy Fredericks
nfredericks@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

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