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RTOG Study Likely Treatment Option for Brain Tumor Patients like Sen. Kennedy
Date:5/22/2008

omized treatment assignment.

Enrolled patients take a daily dose of temozolomide orally during radiotherapy. At the completion of radiotherapy, patients are randomly assigned to receive either the standard treatment schedule consisting of temozolomide once a day for five days every four weeks for up to one year, or the longer schedule, consisting of temozolomide once a day for 21 days every four weeks for up to one year. Patients receive an MRI or CT scan at regular intervals to assess tumor size and treatment effect. The researchers will keep track of the patient's medical condition for the rest of his or her life.

The European Organisation for Research and Treatment of Cancer (EORTC) is a cosponsor of this four-year, multicenter trial, funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).

The RTOG-led study, RTOG 0525/EORTC 26052_22053: Phase III Trial Comparing Conventional Adjuvant Temozolomide with Dose-Intensive Temozolomide in Patients with Newly Diagnosed Glioblastoma, builds upon the work of Mark R. Gilbert, M.D., the RTOG study chair from the University of Texas M.D. Anderson Cancer Center, and the work of Roger Stupp, M.D., University of Lausanne in Switzerland, with the EORTC and the National Cancer Institute of Canada.

The RTOG and the EORTC have played key roles in the development of new cancer treatments for several decades. The goals of the two groups are to increase survival and improve quality of life for patients diagnosed with cancer.

Click (http://www.rtog.org/pdf_file2.html?pdf_document=0525brochure.pdf) to read the RTOG 0525 patient brochure.


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SOURCE Radiation Therapy Oncology Group
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