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RTI International Develops Novel Lung-on-a-Chip
Date:8/14/2014

f the airways and reproduced their physiological interfaces – becoming essentially an "organ-on-chip."

"The microfluidic cell cultures reproduced functions of the airway tissues such as mucus secretion and acted as a barrier to molecules," said Katelyn Sellgren, Ph.D., a postdoctoral research scientist at RTI and first author of the paper. "These properties are critical for inhalation toxicology and drug studies."

The conducting airways are involved in major diseases such as asthma and chronic obstructive lung diseases.

The research team included Scott H. Randell, Ph.D., a leading expert in the culture of primary lung cells, from the Cystic Fibrosis/Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

"Our work demonstrated how a sophisticated investigation tool for the lung can be obtained," Grego said. "Next steps include studies ranging from exposure to environmental toxicants to pulmonary disease modeling and drug screening."

Read the full story at http://www.prweb.com/releases/2014/08/prweb12097437.htm.


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