Navigation Links
RTI International Develops Novel Lung-on-a-Chip
Date:8/14/2014

Research Triangle Park, NC (PRWEB) August 14, 2014

Researchers at RTI International, in collaboration with the University of North Carolina at Chapel Hill, have developed a new lung-on-chip microdevice for laboratory studies of respiratory challenges and therapeutics. The microdevice includes multiple vertically stacked cellular layers that mimic the structure of the airway tissue.

The lung-on-a-chip model, funded by a contract from the Defense Threat Reduction Agency, was featured in an article published in "Lab on a Chip."

"The development of this microfluidic lung model, as well as other organs-on-chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research," said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

Researchers leveraged microfabrication and microfluidic techniques to achieve a system with three vertically stacked fluidic microcompartments separated by nanoporous membranes. Researchers demonstrated that the device was able to support viable cultures of sensitive and physiologically representative primary cells instead of using the more common immortalized cell lines. The engineered cell culture enabled interaction between three cell types of the airways and reproduced their physiological interfaces – becoming essentially an "organ-on-chip."

"The microfluidic cell cultures reproduced functions of the airway tissues such as mucus secretion and acted as a barrier to molecules," said Katelyn Sellgren, Ph.D., a postdoctoral research scientist at RTI and first author of the paper. "These properties are critical for inhalation toxicology and drug studies."

The conducting airways are involved in major diseases such as asthma and chronic obstructive lung diseases.

The research team included Scott H. Randell, Ph.D., a leading expert in the culture of primary lung cells, from the Cystic Fibrosis/Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

"Our work demonstrated how a sophisticated investigation tool for the lung can be obtained," Grego said. "Next steps include studies ranging from exposure to environmental toxicants to pulmonary disease modeling and drug screening."

Read the full story at http://www.prweb.com/releases/2014/08/prweb12097437.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Max International Hosts Convention to Facilitate Health and Business Transformation
2. Expanding Technologies, Markets, Product Lines Highlight Market America
3. SHOP.COM 2014 International Convention
4. Child Family Health International Debuts Intensive Two-week Global Health Programs
5. Foday Auto Debuts the First Special Session Of Guangzhou International Motor Show
6. Forbes Living to Feature Airopedic International, Inc.
7. AMTC Announces Three Major Cities to Host Upcoming Talent Auditions for International Conference
8. International Conference on End of Life: Law, Ethics, Policy and Practice 2014
9. FSH Society’s International Meeting to Bring Together Patients and Researchers From Around the World to Explore New Insights on Rare Disease
10. Melbourne Board Certified Facial Plastic Surgeon Invited to Speak at International Conference
11. Tazca Connects and TeleHealth International Partnership to Deploy Turnkey TeleHealth Solutions for Disadvantaged Rural Areas Worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... As health professionals work to improve their approach to healthcare, ... doing more than filling out a survey; in many cases health professionals and patients ... health care and research on the importance of active engagement with patients and members ...
(Date:10/13/2017)... Ky. (PRWEB) , ... October 13, 2017 , ... The ... MPH to become its next President and Chief Executive Officer, succeeding Dr. James C. ... CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
Breaking Medicine Technology: