Navigation Links
RTI International Develops Novel Lung-on-a-Chip
Date:8/14/2014

Research Triangle Park, NC (PRWEB) August 14, 2014

Researchers at RTI International, in collaboration with the University of North Carolina at Chapel Hill, have developed a new lung-on-chip microdevice for laboratory studies of respiratory challenges and therapeutics. The microdevice includes multiple vertically stacked cellular layers that mimic the structure of the airway tissue.

The lung-on-a-chip model, funded by a contract from the Defense Threat Reduction Agency, was featured in an article published in "Lab on a Chip."

"The development of this microfluidic lung model, as well as other organs-on-chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research," said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

Researchers leveraged microfabrication and microfluidic techniques to achieve a system with three vertically stacked fluidic microcompartments separated by nanoporous membranes. Researchers demonstrated that the device was able to support viable cultures of sensitive and physiologically representative primary cells instead of using the more common immortalized cell lines. The engineered cell culture enabled interaction between three cell types of the airways and reproduced their physiological interfaces – becoming essentially an "organ-on-chip."

"The microfluidic cell cultures reproduced functions of the airway tissues such as mucus secretion and acted as a barrier to molecules," said Katelyn Sellgren, Ph.D., a postdoctoral research scientist at RTI and first author of the paper. "These properties are critical for inhalation toxicology and drug studies."

The conducting airways are involved in major diseases such as asthma and chronic obstructive lung diseases.

The research team included Scott H. Randell, Ph.D., a leading expert in the culture of primary lung cells, from the Cystic Fibrosis/Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

"Our work demonstrated how a sophisticated investigation tool for the lung can be obtained," Grego said. "Next steps include studies ranging from exposure to environmental toxicants to pulmonary disease modeling and drug screening."

Read the full story at http://www.prweb.com/releases/2014/08/prweb12097437.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Max International Hosts Convention to Facilitate Health and Business Transformation
2. Expanding Technologies, Markets, Product Lines Highlight Market America
3. SHOP.COM 2014 International Convention
4. Child Family Health International Debuts Intensive Two-week Global Health Programs
5. Foday Auto Debuts the First Special Session Of Guangzhou International Motor Show
6. Forbes Living to Feature Airopedic International, Inc.
7. AMTC Announces Three Major Cities to Host Upcoming Talent Auditions for International Conference
8. International Conference on End of Life: Law, Ethics, Policy and Practice 2014
9. FSH Society’s International Meeting to Bring Together Patients and Researchers From Around the World to Explore New Insights on Rare Disease
10. Melbourne Board Certified Facial Plastic Surgeon Invited to Speak at International Conference
11. Tazca Connects and TeleHealth International Partnership to Deploy Turnkey TeleHealth Solutions for Disadvantaged Rural Areas Worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... consulting firm in Pennsylvania, is pleased to offer in-home and online newborn ... that sleep deprivation has on the body,” says company owner Courtney Zentz, a ...
(Date:9/22/2017)... ... September 22, 2017 , ... TopConsumerReviews.com recently ... Native Remedies that helps promote pancreatic health and regulate blood sugar levels ... prescription-based approaches can have negative side effects, and with the changes in today’s ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: ... even the lost, have value to God. “Letters From Home” is the creation of ... member of the President’s Cabinet of Jerry Savelle Ministries International, who has traveled and ...
(Date:9/21/2017)... FL (PRWEB) , ... September 21, 2017 , ... 38-Year-Old ... Aesthetic Surgery Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet ... Top 40 Under 40 is an annual award that was started in ...
(Date:9/21/2017)... ... 21, 2017 , ... Hair restoration surgery is having a ... the International Society of Hair Restoration Surgery (ISHRS). The worldwide volume ... with 635,189 procedures performed in 2016. , "Like other forms of cosmetic ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... Sept. 12, 2017   EcoVadis , the leading platform for environmental, ... first annual edition of its Global CSR Risk and Performance Index. The ... EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points across ... ... ...
(Date:9/9/2017)... NEW YORK , Sept. 8, 2017 ... largest independent supplier of medical equipment, supplies, drugs, ... that it has entered into an agreement to acquire ... surgical equipment based in Holtsville, New York ... which specializes in supplying new and emerging medical practices, ...
(Date:9/7/2017)... 2017 Caris Life Sciences, a leading ... promise of precision medicine, today announced results from ... its molecular profiling approach in guiding therapeutic strategies ... plus (CGP+) with Caris Molecular Intelligence ® ... molecular level, leading to more therapeutic options and ...
Breaking Medicine Technology: