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RSV study shows potential for vaccine strategies to protect babies
Date:11/15/2012

Research by the University of Warwick indicates that vaccinating families could protect young babies against a common winter virus which can be fatal for infants under six months.

Respiratory syncytial virus (RSV) typically leads to mild, cold-like symptoms in adults and older children but can be more serious and even fatal in infants under the age of six months as it can lead to bronchiolitis and pneumonia.

The virus is commonly found all over the world. In the UK, outbreaks generally start in November or December and last four to five months, peaking over the Christmas and New Year period.

According to the Health Protection Agency, in England, 28 per 1000 hospital admissions in children aged under one year were attributed to RSV each year. Globally, the most recent estimates set the RSV pneumonia burden at 33 million cases and up to 199,000 deaths every year.

Up until now it was not clear whether babies under six months were more at risk of an RSV infection leading to severe respiratory disease because it was their first infection and they lacked immunity to the virus, or whether it was down to the age of the babies.

A new University of Warwick-led study, published in the American Journal of Epidemiology and funded by the Wellcome Trust, has now found that the severe disease risk is principally age-related.

This means the physiological changes associated with growing older such as for example an increase in size of the small airways of the lungs are more important in reducing the risk of developing severe respiratory disease than previous exposure to the disease.

This finding is significant because it shows that increasing the average age that a child is exposed to RSV infection would lead to fewer cases developing into severe respiratory disease.

A way to do this is through vaccination.

Development of a vaccine for the key target age group of newborn babies between 1-3 months of age remains elusive despite 50
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Contact: Anna Blackaby
a.blackaby@warwick.ac.uk
44-024-765-75910
University of Warwick
Source:Eurekalert

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