Navigation Links
RSNA: Concussion Patients Show Alzheimer’s-like Brain Abnormalities
Date:6/17/2013

Oak Brook, IL (PRWEB) June 17, 2013

The distribution of white matter brain abnormalities in some patients after mild traumatic brain injury (MTBI) closely resembles that found in early Alzheimer’s dementia, according to a new study published online in the journal Radiology.

“Findings of MTBI bear a striking resemblance to those seen in early Alzheimer’s dementia,” said the study’s lead author, Saeed Fakhran, M.D., assistant professor of radiology in the Division of Neuroradiology at the University of Pittsburgh School of Medicine. “Additional research may help further elucidate a link between these two disease processes.”

MTBI, or concussion, affects more than 1.7 million people in the United States annually. Despite the name, these injuries are by no means mild, with approximately 15 percent of concussion patients suffering persistent neurological symptoms.

“Sleep-wake disturbances are among the earliest findings of Alzheimer’s patients, and are also seen in a subset of MTBI patients,” Dr. Fakhran said. “Furthermore, after concussion, many patients have difficulty filtering out white noise and concentrating on the important sounds, making it hard for them to understand the world around them. Hearing problems are not only an independent risk factor for developing Alzheimer’s disease, but the same type of hearing problem seen in MTBI patients has been found to predict which patients with memory problems will go on to develop Alzheimer's disease.”

For the study, Dr. Fakhran and colleagues set out to determine if there was a relationship between white matter injury patterns and severity of post-concussion symptoms in MTBI patients with normal findings on conventional magnetic resonance imaging (MRI) exams. The researchers studied data from imaging exams performed on 64 MTBI patients and 15 control patients, using an advanced MRI technique called diffusion tensor imaging, which identifies microscopic changes in the brain's white matter.

The brain’s white matter is composed of millions of nerve fibers called axons that act like communication cables connecting various regions of the brain. Diffusion tensor imaging produces a measurement, called fractional anisotropy, of the movement of water molecules along axons. In healthy white matter, the direction of water movement is fairly uniform and measures high in fractional anisotropy. When water movement is more random, fractional anisotropy values decrease.

Of the MTBI patients, 42 (65.6 percent) were men, and the mean age was 17. Sports injury was the reason for concussion in two-thirds of the patients. All patients underwent neurocognitive evaluation with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). The researchers analyzed correlation between fractional anisotropy values, the ImPACT total symptom score, and findings of sleep-wake disturbances.

Sleep-wake disturbances are among the most disabling post-concussive symptoms, directly decreasing quality of life and productivity and magnifying post-concussion memory and social dysfunction.

The results showed a significant correlation between high ImPACT total symptom score and reduced fractional anisotropy at the gray-white junction, most prominently in the auditory cortex. Significantly decreased fractional anisotropy was found in patients with sleep-wake disturbances in the parahippocampal gyri relative to patients without sleep-wake disturbances.

“When we sleep, the brain organizes our experiences into memories, storing them so that we can later find them,” Dr. Fakhran said. “The parahippocampus is important for this process, and involvement of the parahippocampus may, in part, explain the memory problems that occur in many patients after concussion.”

According to Dr. Fakhran, the results suggest that the true problem facing concussion patients may not be the injury itself, but rather the brain’s response to that injury.

“Traditionally, it has been believed that patients with MTBI have symptoms because of abnormalities secondary to direct injury,” he said. “Simply put, they hit their head, damaged their brain at the point of trauma and thus have symptoms from that direct damage. Our preliminary findings suggest that the initial traumatic event that caused the concussion acts as a trigger for a sequence of degenerative changes in the brain that results in patient symptoms and that may be potentially prevented. Furthermore, these neurodegenerative changes are very similar to those seen in early Alzheimer’s dementia.”

The researchers hope that these findings may lead to improved treatments in the future.

“The first step in developing a treatment for any disease is understanding what causes it,” Dr. Fakhran said. “If we can prove a link, or even a common pathway, between MTBI and Alzheimer’s, this could potentially lead to treatment strategies that would be potentially efficacious in treating both diseases.”

“Symptomatic White Matter Changes in Mild Traumatic Brain Injury Resemble Pathologic Features of Early Alzheimer's Dementia.” Collaborating with Dr. Fakhran were Karl Yaeger, M.D., and Lea Alhilali, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)

RSNA is an association of more than 51,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10822858.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. RSNA: ‘Heading’ a Soccer Ball Could Lead to Brain Injury
2. RSNA: Digital Mammography Cancer Detection Rates May Vary Significantly
3. RSNA: Benefits of CT Outweigh Cancer Risks in Young Adults
4. RSNA: New Study Finds Brain Angioplasty and Stents Safe and Effective for Stroke Patients
5. Concussion patients show Alzheimers-like brain abnormalities
6. New study shows most youth football player concussions occur during games, not practice
7. U of A research leads to enhanced CFL concussion guidelines
8. Study raises concerns that teen athletes continue to play with concussion symptoms
9. Kids Concussion Recovery Varies by Symptom Severity: Study
10. More severe concussion symptoms lead to longer recovery time
11. Study finds newspapers have changed coverage of ice hockey concussions over last quarter-century
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Hanna Boys Center ... will be the keynote speaker at its second Professional Networking Breakfast on March ... which develops comprehensive strategies to create and expand opportunities for boys and young ...
(Date:2/21/2017)... ... , ... As recently as 2015, rhinoplasty was one of the Top 5 ... Some patients want to make a change in the appearance of their nose while ... The team at usrhinoplasty.org is expanding its article database to better inform ...
(Date:2/21/2017)... ... 2017 , ... Ray Insurance Agencies, a Dallas area firm providing asset protection ... on a six month charity event aimed at raising local support and donations that ... of the deadliest diseases in America; more than 7.5 million people die from cancer ...
(Date:2/21/2017)... ... February 21, 2017 , ... American Veterinarian™, ... medicine, will be launching its first bi-monthly issue of 2017 in February. The ... practice management, and One Health. , In making the announcement, American Veterinarian™ ...
(Date:2/21/2017)... Michigan (PRWEB) , ... February 21, 2017 , ... ... to the United States during Black History Month (officially African American History ... to many fields of American society of a diverse race of people, but ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... , Feb. 21, 2017 Research and Markets ... Devices - Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive ... , Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. Also, a ...
(Date:2/21/2017)... Research and Markets has announced the addition of the ... their offering. ... research Uterine cancer Drugs Price Analysis and Strategies - 2016, provides drug ... The research answers the following questions: What are ... are they positioned in the Global Uterine cancer market? ...
(Date:2/20/2017)... Feb. 20, 2017   MedPlast, Inc. , ... industry, announced today that it has signed a ... Device Manufacturing Services business.   The acquisition broadens MedPlast,s ... a leading services provider to the world,s largest ... further expand the company,s capabilities in assembly and ...
Breaking Medicine Technology: