Navigation Links
RSNA: Brain Chemical Ratios Help Predict Developmental Delays in Preterm Infants
Date:12/16/2013

Oak Brook, IL (PRWEB) December 16, 2013

Researchers have identified a potential biomarker for predicting whether a premature infant is at high risk for motor development problems, according to a study published online in the journal Radiology.

“We are living in an era in which survival of premature birth is more common,” said Giles S. Kendall, Ph.D., consultant for the neonatal intensive care unit at University College London Hospitals NHS Foundation Trust and honorary senior lecturer of neonatal neuroimaging and neuroprotection at the University College London. “However, these infants continue to be at risk for neurodevelopmental problems.”

Patients in the study included 43 infants (24 male) born at less than 32 weeks gestation and admitted to the neonatal intensive care unit (NICU) at the University College of London between 2007 and 2010. Dr. Kendall and his research team performed magnetic resonance imaging (MRI) and MR spectroscopy (MRS) exams on the infants at their approximate expected due dates (or term-equivalent age). MRS measures chemical levels in the brain.

The imaging studies were focused on the white matter of the brain, which is composed of nerve fibers that connect the functional centers of the brain.

“The white matter is especially fragile in the newborn and at risk for injury,” Dr. Kendall explained.

One year later, 40 of the 43 infants were evaluated using the Bayley Scales of Infant and Toddler Development, which assess fine motor, gross motor and communication abilities. Of the 40 infants evaluated, 15 (38 percent) had abnormal composite motor scores and four (10 percent) showed cognitive impairment.

Statistical analysis of the MRS results and Bayley Scales scores revealed that the presence of two chemical ratios—increased choline/creatine (Cho/Cr) and decreased N-acetylaspartate/choline (NAA/Cho)—at birth were significantly correlated with developmental delays one year later.

“Low N-acetylaspartate/choline and rising choline/creatine observed during MRS at the baby’s expected due date predicted with 70 percent certainty which babies were at high risk for motor development problems at one year,” Dr. Kendall said.

Dr. Kendall said a tool to predict the likelihood of a premature baby having neurodevelopmental problems would be useful in determining which infants should receive intensive interventions and in testing the effectiveness of those therapies.

“Physiotherapy interventions are available but are very expensive, and the vast majority of premature babies don’t need them,” Dr. Kendall said. “Our hope is to find a robust biomarker that we can use as an outcome measure so that we don’t have to wait five or six years to see if an intervention has worked.”

Dr. Kendall said severe disability associated with premature births has decreased over the past two decades as a result of improved care techniques in the NICU. However, many premature infants today have subtle abnormalities that are difficult to detect with conventional MRI.

“There’s a general shift away from simply ensuring the survival of these infants to how to give them the best quality of life,” he said. “Our research is part of an effort to improve the outcomes for prematurely born infants and to identify earlier which babies are at greater risk.”

###

“White Matter NAA/Cho and Cho/Cr on MRS Predict Motor Outcome in Preterm Infants.” Collaborating with Dr. Kendall were Andrew Melbourne, Ph.D., Samantha Johnson, Ph.D., David Price, M.Sc., Alan Bainbridge, Ph.D., Roxanna Gunny, MRCP, FRCR, Angela Huertas-Ceballos, FRCPCH, M.Sc., Ernest B. Cady. FInstP, B.Sc., Sebastian Ourselin, Ph.D., Neil Marlow, D.M., FMedSci, and Nicola J. Robertson, M.B., Ch.B., Ph.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)

RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.

Read the full story at http://www.prweb.com/releases/2013/12/prweb11409154.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. RSNA: MR Spectroscopy Shows Differences in Brains of Preterm Infants
2. RSNA: Embolization Procedure Aids in Weight Loss
3. RSNA: Self-Referral Spurs Unnecessary MRI Exams for Patients
4. RSNA: Multicenter Trial Finds BI-RADS 3 Breast Lesions Have Low Cancer Rate
5. RSNA: Tomosynthesis Reduces Breast Cancer Screening Recall Rate
6. RSNA: Some Women With Abnormal Breast Lesions May Avoid Surgery
7. RSNA: Hospital Mammography Recall Rates Higher
8. RSNA: Fat in Organs and Blood May Increase Risk of Osteoporosis
9. RSNA: Exercise Benefits Patients with Type 2 Diabetes
10. RSNA: Atherosclerosis in Abdominal Aorta May Signal Future Heart Attack, Stroke
11. RSNA: Concussion Patients Show Alzheimer’s-like Brain Abnormalities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Patients who want to receive ... now meet with Dr. Joseph Bedich for a consultation, with or without a referral. ... oral health and functionality. , Dr. Bedich offers a variety of cosmetic ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. ... of the HP3 (High-Performance Periodontal Practice) continuing education (CE) series. As a compassionate ... in his field by attending numerous CE courses each year. His recent course, ...
(Date:5/24/2017)... Brentwood, TN (PRWEB) , ... May 24, 2017 ... ... announced the addition of ExtraHop to its solutions portfolio. ExtraHop delivers an analytics-first ... and security of every IT system, from the datacenter to the cloud to ...
(Date:5/24/2017)... ... 2017 , ... Rob Lowe is a sought after actor, and also serves ... the public important topics from all aspects of life, and a new segment is ... feet and ankles. , Podiatry is essential to people’s overall well-being, and if viewers ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Technique, technique, ... back injury when either lifting weights for strength training and exercise or simply lifting ... Center . , “Body position is everything,” Dr. Chang says. “Improper technique in lifting ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)...  As the specialty pharmacy industry and the ... the revolutionary shift from volume-based to value-based care, ... patient outcomes and shaping the future of the ... from clinical trials and toward data that reveals ... therapy utilization in precise patient populations. Therigy ® ...
(Date:5/18/2017)... -- Bayer announced today that the latest research from across ... 53 rd Annual Meeting of the American Society ... Chicago . The ... and thyroid cancers, as well as lymphomas, and includes ... of copanlisib in patients with relapsed or refractory follicular ...
(Date:5/15/2017)... 2017 Enterin Inc., a privately-held CNS pharmaceutical company ... compounds to treat Parkinson,s disease (PD), has enrolled the first ... 1/2a randomized, controlled, multicenter study involving patients with PD and ... patients over a 9-to-12-month period. The first stage is open ... PD. Participating sites include Denver , ...
Breaking Medicine Technology: