Navigation Links
RSNA - CT Angiography Helps Predict Heart Attack Risk
Date:2/19/2013

Oak Brook, Ill. (PRWEB) February 19, 2013

Coronary computed tomography angiography (CCTA) is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors, such as high cholesterol or high blood pressure, according to a new study published online, February 19, in the journal Radiology.

“CCTA should be considered as an appropriate first- line test for patients with atypical chest pain and suspected but not confirmed coronary artery disease,” said the study’s lead author, Jonathon Leipsic, M.D., FRCPC, from the University of British Columbia in Vancouver.

Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. Treatment often involves addressing modifiable cardiovascular risk factors such as elevated cholesterol, high blood pressure, diabetes and smoking. However, some risk factors, like family history, are not modifiable, and no risk models exist to help guide clinicians to identify those symptomatic patients without cardiac risk factors who are at an increased risk of death and myocardial infarction.

“This scenario, where patients are symptomatic but have no cardiac risk factors, comes up often in clinical practice,” Dr. Leipsic said. “We lack a good tool to stratify these patients into risk groups.”

CCTA is a noninvasive test that has shown high accuracy for the diagnosis or exclusion of coronary artery disease in individuals. However, referral for patients with suspected coronary artery disease is often based on clinical risk factor scoring. Less is known about the prognostic value of CCTA in individuals with no medically modifiable risk factors.

In the first study of its kind, Dr. Leipsic and colleagues correlated CCTA findings with the risk of major adverse cardiac events in 5,262 patients with suspected coronary artery disease but no medically modifiable risk factors. They culled the data from the Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter (CONFIRM) registry.

After an average follow-up of 2.3 years, 104 patients had experienced a major adverse cardiovascular event. The researchers identified a high prevalence of coronary artery disease in the study group, despite the absence of modifiable risk factors. More than one-quarter of the patients had non-obstructive disease or disease related to the buildup of plaque in the arteries, and another 12 percent had obstructive disease with a greater than 50 percent narrowing in a coronary artery.

“We found that patients with narrowing of the coronary arteries on CT had a much higher risk of an adverse cardiac event,” Dr. Leipsic said. “This was true even for those without a family history of heart disease.”

Both symptomatic and asymptomatic patients with obstructive disease faced an increased risk for a major cardiac event. In contrast, the absence of coronary artery disease on CCTA was associated with a very low risk of a major event.

The findings highlight the need for refinement in the evaluation of individuals who may be missed by traditional methods of coronary artery disease evaluation.

“If a patient shows up with vague symptoms and no medically modifiable risk factors, doctors often dismiss them or do a treadmill test, which won’t identify atherosclerosis and only has a modest sensitivity for detecting obstructive disease,” Dr. Leipsic said.

CCTA could help address this problem, Dr. Leipsic added, by helping to diagnose or rule out coronary artery disease and identifying those who may benefit from more intensive therapy.

The researchers continue to study the CONFIRM data with the aim to learn more about the relationship between plaque and heart attacks and the longer-term outlook for patients with coronary artery disease.

“We are now collecting data to determine the prognostic value of CCTA after five years or more of follow-up, which will be very important for the field,” Dr. Leipsic said.

###

“Cardiovascular Risk Among Stable Individuals with Suspected Coronary Artery Disease But No Medically
Modifiable Risk Factors: Results from an International Multicenter Study of 5262 Patients.” Collaborating with Dr. Leipsic were Carolyn M. Taylor, M.D., Gilat Grunau, Brett G. Heilbron, M.B.B.S., G.B.J. Mancini, M.D., Stephan Achenbach, M.D., Mouaz Al-Mallah, M.D., Daniel S. Berman, M.D., Matthew J. Budoff, M.D., Filippo Cademartiri, M.D., Ph.D., Tracy Q. Callister, M.D., Hyuk-Jae Chang, M.D., Victor Y. Cheng, M.D., Kavitha Chinnaiyan, M.D., Benjamin J.W. Chow, M.D., Augustin Delago, M.D., Martin Hadamitzky, M.D., Joerg
Hausleiter, M.D., Ricardo Cury, M.D., Gudrun Feuchtner, M.D., Yong-Jin Kim, M.D., Philipp A. Kaufmann, M.D., Fay Y. Lin, M.D., Erica Maffei, M.D., Gilbert Raff, M.D., Leslee J. Shaw, Ph.D., Todd C. Villines, M.D., and James K. Min, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)

RSNA is an association of more than 51,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA(dot)org)

For patient-friendly information on CT angiography, visit RadiologyInfo(dot)org.

Read the full story at http://www.prweb.com/releases/2013/2/prweb10424275.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. CT angiography helps predict heart attack risk
2. Positive stress helps protect eye from glaucoma
3. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
4. Unusual protein helps regulate key cell communication pathway
5. Equal access to care helps close survival gap for young African-American cancer patients
6. First-of-its-kind Menopause Map helps women navigate treatment
7. Palliative care resource helps ease changes
8. Fertilizing bone marrow helps answer why some cancers spread to bones
9. Two-Drug Combo Helps Teens With Migraines
10. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
11. Breast MRI helps predict chemotherapys effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... management assistance and financial planning services to families and business owners in northern ... event that promises to provide support to area adults with developmental challenges. , ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... and Theater of Witness , was awarded a $300,000 grant from ... program which fosters empathy, comfort with ambiguity and the recognition of one’s own ...
(Date:7/21/2017)... ... ... Overseer at The House of Yahweh in Abilene, Texas, has written a new post this ... world leaders to be more open about positive changes. Yisrayl says the use of force ... peaceful and positive way to solve all; yes, all issues, and he is ready to ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... Nature’s Tears® EyeMist®, the signature product of her research center at Bio-Logic Aqua ... world’s largest population and the greatest number of sufferers of blindness. “We think ...
(Date:7/21/2017)... ... July 21, 2017 , ... How physicians and athletic trainers ... say researchers presenting their work at the American Orthopaedic Society for Sports ... evaluating the patterns of change in concussion symptom presentation, diagnostic tools used and ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... July 10, 2017 The Institute for In ... is the recipient of a VITROCELL® inhalation exposure system ... Science Consortium. The device, which is designed to replace ... human lung cells to airborne test materials in an ... the VITROCELL® system for testing combustible tobacco products, as ...
(Date:7/6/2017)... nutrition division of Diplomat Specialty Infusion Group, is celebrating a decade of ... To celebrate its anniversary, ThriveRx recently launched a redesigned website at ... organization to create the best user experience for consumers and health care ... Diplomat Pharmacy ... "We,ve made several great strides throughout the past 10 ...
(Date:7/5/2017)... July 5, 2017   BioLife Solutions , Inc. ... and marketer of proprietary clinical grade cell and tissue ... media ("BioLife"), today announced that it has reached an ... and largest shareholder, to modify its existing credit facility ... the modification, WAVI agreed to exchange its existing $4.25 ...
Breaking Medicine Technology: