Navigation Links
RNA promotes metastasis in lung cancer
Date:2/5/2013

The vast majority approximately 80 percent of our DNA does not code for proteins, yet it gets transcribed into RNA. These RNA molecules are called non-coding and fulfill multiple tasks in the cell. Alongside a well-studied group of small RNAs, there is also a class of so-called long non-coding RNAs consisting of more than 200 nucleotides.

Long non-coding RNAs regulate cellular processes such as cell cycle, growth and cell death. Therefore, it came as no surprise that many of these controlling molecules are linked to the progression of cancer. An example is the non-coding RNA MALAT1, which is considered a marker for disease progression in various forms of lung cancer: "The more MALAT1 tumor cells produce, the higher the odds for metastasis and a very unfavorable course of the disease," says Dr. Sven Diederichs, who discovered the molecule as part of his doctoral thesis. Diederichs now leads a junior research group at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Institute of Pathology of Heidelberg University.

In his current project, Diederichs has investigated the actual mechanisms used by MALAT1 to interfere in cellular processes and to promote metastasis. Diederichs and his team recently developed a method for selectively silencing long non-coding RNAs in the cell. To do so, the researchers integrate signaling sequences into the DNA which cause RNA transcripts to be broken down immediately after being formed. Then they analyze resulting changes in cellular biology.

For the first time, Diederichs and his team have been able to achieve almost complete silencing of MALAT1 in lung cancer cell cultures. In the modified cells they found that MALAT1 regulates numerous genes involved in metastasis. As a result, MALAT1-deficient tumor cells have impaired mobility and are less capable of invading surrounding tissue. When implanted in mice, they formed considerably less tumor nodules in the animals' lungs than cancer cells with intact MALAT1.

Encouraged by this result, the investigators explored whether it is also possible to block MALAT1 and thus prevent metastasis in an intact organism. In collaboration with ISIS Pharmaceuticals, Inc., the Heidelberg scientists developed short nucleic acid strands (antisense oligonucleotides) which are taken up by the cells and specifically block RNA molecules.

In mice injected with human lung cancer cells, MALAT1-specific antisense strands successfully inhibited metastasis formation. The animals' lungs showed fewer and smaller tumor nodules than those of control animals that had not been given the substance.

"Ten years after we discovered MALAT1 as a predictive marker in lung cancer, we now understand how this non-coding RNA influences metastasis. Moreover, this RNA has turned out to be a potential target for an innovative treatment with antisense RNAs." Diederichs and his team will further investigate this promising approach aiming to eventually prevent lung cancer from spreading.


'/>"/>

Contact: Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
2. Cohen Children’s Medical Center of New York Promotes Brand and Wellness with Community Play Area Sponsorship
3. Hepatitis B virus promotes oncogenesis through microRNA modulation
4. Assure A Smile Promotes Oral Health Awareness in Miami with New Website
5. Blue Sky Systems, LLC Promotes Health through Supplements via Website and Blog
6. Smartphones: Artists Promotes Face-to-Face Conversation
7. The Hong Kong Polytechnic University promotes knowledge enterprises through MAKE Award
8. Smile Reef Pediatric Dentist Promotes Dental Care for Kids During the Holidays
9. Alcoholics Anonymous participation promotes long-term recovery
10. Scientists discover mechanism that promotes lung cancer growth and survival
11. RANK protein promotes the initiation, progression and metastasis of human breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands Inc., one ... the United States, today announced the grand opening of another affiliated Bright ... will enjoy convenient hours, a comfortable office, and full-service care at the new ...
(Date:8/31/2020)... Conn. (PRWEB) , ... August 31, 2020 , ... ... device intended to improve outcomes for patients with advanced heart failure, today announced ... (SBIR) grant in the amount of $555,358 from the National Heart, Lung, and ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... Nourished Group set out to continue helping the specialty-diet community connect with ... new gluten-free products, get coupons, enter giveaways, chat with brands & watch over ...
(Date:8/27/2020)... ... 27, 2020 , ... The team at Sikara MedSpa is ... retreat. The practice is centered on results and providing the ultimate patient experience ... to be a sanctuary for total body renewal and aesthetic revitalization, Sikara Medspa ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... Md. (PRWEB) , ... September 02, 2020 , ... ... Dr. Jonathan Lee . Dr. Lee will work at Bethesda Dermatopathology Lab. ... with his B.A. from the University of California, Berkley. He went on to receive ...
(Date:9/1/2020)... , ... September 01, 2020 , ... ... been appointed to serve as Secretary to the Board of Trustees and committee ... Mile High United Way is a Denver-based nonprofit organization that fights for the ...
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer Awareness Month. ... any other cancer of the female reproductive system. The American Cancer Society estimates ... 14,000 women will die from this disease. Throughout the month of September, Women’s ...
Breaking Medicine Technology: