Navigation Links
RNA promotes metastasis in lung cancer
Date:2/5/2013

The vast majority approximately 80 percent of our DNA does not code for proteins, yet it gets transcribed into RNA. These RNA molecules are called non-coding and fulfill multiple tasks in the cell. Alongside a well-studied group of small RNAs, there is also a class of so-called long non-coding RNAs consisting of more than 200 nucleotides.

Long non-coding RNAs regulate cellular processes such as cell cycle, growth and cell death. Therefore, it came as no surprise that many of these controlling molecules are linked to the progression of cancer. An example is the non-coding RNA MALAT1, which is considered a marker for disease progression in various forms of lung cancer: "The more MALAT1 tumor cells produce, the higher the odds for metastasis and a very unfavorable course of the disease," says Dr. Sven Diederichs, who discovered the molecule as part of his doctoral thesis. Diederichs now leads a junior research group at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Institute of Pathology of Heidelberg University.

In his current project, Diederichs has investigated the actual mechanisms used by MALAT1 to interfere in cellular processes and to promote metastasis. Diederichs and his team recently developed a method for selectively silencing long non-coding RNAs in the cell. To do so, the researchers integrate signaling sequences into the DNA which cause RNA transcripts to be broken down immediately after being formed. Then they analyze resulting changes in cellular biology.

For the first time, Diederichs and his team have been able to achieve almost complete silencing of MALAT1 in lung cancer cell cultures. In the modified cells they found that MALAT1 regulates numerous genes involved in metastasis. As a result, MALAT1-deficient tumor cells have impaired mobility and are less capable of invading surrounding tissue. When implanted in mice, they formed considerably less tumor nodules in the animals' lu
'/>"/>

Contact: Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
2. Cohen Children’s Medical Center of New York Promotes Brand and Wellness with Community Play Area Sponsorship
3. Hepatitis B virus promotes oncogenesis through microRNA modulation
4. Assure A Smile Promotes Oral Health Awareness in Miami with New Website
5. Blue Sky Systems, LLC Promotes Health through Supplements via Website and Blog
6. Smartphones: Artists Promotes Face-to-Face Conversation
7. The Hong Kong Polytechnic University promotes knowledge enterprises through MAKE Award
8. Smile Reef Pediatric Dentist Promotes Dental Care for Kids During the Holidays
9. Alcoholics Anonymous participation promotes long-term recovery
10. Scientists discover mechanism that promotes lung cancer growth and survival
11. RANK protein promotes the initiation, progression and metastasis of human breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... On Saturday, September 19, 2015, Diane ... Foundation (Meso Foundation) will present an educational program titled “Asbestos and Your Health.” ... through 9:30 PM (doors open at 6:45pm) at Calvary United Methodist Church, 16 E ...
(Date:8/29/2015)... ... August 29, 2015 , ... Brands like Toppik , Eau Thermale ... costs. , “Before, a threshold of $49.00 was required to qualify for free standard ... for free standard shipping for customers regardless of the item’s selling price.” , With ...
(Date:8/29/2015)... ... ... popular television program VOICES IN AMERICA, hosted by legendary star of the stage and ... segment to the subject of diabetes. Diabetes is a debilitating health condition that is ... advancements in medical science may prove to be a significant breakthrough that sufferers have ...
(Date:8/28/2015)... Columbus, Ohio (PRWEB) , ... August 28, 2015 ... ... Saturday’s Imagine No Malaria Day at the Zoo to celebrate children helping children, ... people and their congregations throughout West Ohio have contributed to the United Methodist ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... Devices:, Understanding the FDA’s Position and Best Practices for Compliance, **Presented by ... , This workshop, chaired by internationally renowned expert Fubin Wu, has been ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Applied Research Foundation to Hold Educational Class About Asbestos and Mesothelioma Prevention 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5
... to toughen anti-smoking laws, restricting smoking in public places ... Cabinet further approved a Health and Family Welfare Ministry ... 2003 Act in the first week of the monsoon ... Dasmunsi told reporters after a Cabinet meeting in New ...
... has gripped people in Himachal Pradesh. ... Deol area of Baijnath sub-division in Himachal Pradesh's Kangra ... are suspecting the symptoms to be that of scrub ... which is spread through bites of ticks and mites. ...
... teens indulgence in non-suicidal injury is more common ... self-injury is the deliberate, direct destruction of body ... findings are important because it suggests that NSSI ... population than previously thought, says lead author Elizabeth ...
... both hands in a letter bomb explosion. Now the Austrian police ... a double hand transplant. ,His motto, he likes to ... medical wonder with an iron will, was one the victims of ... arrest in 1997 with a wave of xenophobic attacks that killed ...
... Restless legs syndrome (RLS) remains a common, yet ... years of research and increased disease recognition. ... among physicians and people with RLS, Boehringer Ingelheim ... about the symptoms, diagnosis and treatment of RLS ...
... to quality health care in India, has suggested two things ... private-public partnership. , , According to the Federation ... to spend around $203 billion (Rs 912,375 crores), if ... attained by 2012. ,The FICCI itself has put ...
Cached Medicine News:Health News:Government to Toughen Its Anti-smoking Laws 2Health News:Self-harming Among Teens More Common Than Thought 2Health News:Self-harming Among Teens More Common Than Thought 3Health News:Around the World in 86 Days ... on Motorbike With Double-hand Transplant 2Health News:Around the World in 86 Days ... on Motorbike With Double-hand Transplant 3Health News:Understanding Restless Legs Syndrome 2Health News:FICCI Proposes Models To Solve Indias Healthcare Crisis 2
(Date:8/28/2015)... -- The global mHealth market ... 2020, growing at a CAGR of 47.6% from 2013 ... View Research, Inc. Monitoring services is expected to grow ... 2020.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... of chronic diseases such as cancer, heart ailments, and ...
(Date:8/27/2015)... 2015  A recent study by Feucht et ... the Arthrosurface HemiCAP® Wave implant, which is based ... design implant for isolated patellofemoral disease. While both ... pain scores, none of the patients in the ... 53% of the patients in the "onlay" group, ...
(Date:8/27/2015)... , Aug. 27, 2015 Biosimilars are ... applauds the U.S. Food and Drug Administration (FDA) ... name in its draft guidance issued today. The ... products proposes distinguishable names, calling for biological products ... FDA-designated suffix. This proposal reflects the agency,s thinking ...
Breaking Medicine Technology:mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2
... 1, 2011    Advanced Biologics, ( www.advancedbiologics.com ) ... newest product within the OsteoAMP ® platform ... meeting this week in Chicago, IL.  OsteoAMP Structural ... that demonstrates osteoinductive properties in-vivo.  Initial product offerings ...
... 2011 Merz Aesthetics, Inc., the exclusive distributor of ... launch of the "STAND AND DELIVER" program.  In partnership ... selected for their significant abilities to STAND AND DELIVER, ... a stand by making a difference in their communities. ...
Cached Medicine Technology:Advanced Biologics Launches OsteoAMP® Structural at the 26th Annual Meeting of the North American Spine Society 2Merz Aesthetics and Inspirational Women Join Forces to Recognize Women Who STAND AND DELIVER 2Merz Aesthetics and Inspirational Women Join Forces to Recognize Women Who STAND AND DELIVER 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: