Navigation Links
RI Hospital researchers identify components in C. diff that may lead to better treatment

PROVIDENCE, R.I. Rhode Island Hospital researchers have identified components in Clostridium difficile (C. diff) that may lead to new diagnostic tools, and ultimately more timely and effective treatment for this often fatal infection. C. diff is a spore-forming bacterium that causes severe diarrhea and is responsible for 14,000 deaths annually in the U.S. The study is published online in advance of print in the Journal of Molecular Diagnostics.

In this study, researchers identified components of the C. diff bacteria that can be used to develop a rapid diagnostic test to determine if a patient with a diarrheal illness has C. diff infection and, if so, if the infection is due to a hypervirulent strain of this bacterium. Such a determination may lead to more rapid initiation of appropriate antibiotics in infected patients with the hope of improving their outcome.

"C. difficle can be a life-threatening infection," said Leonard Mermel, D.O., medical director of the department of epidemiology and infection control at Rhode Island Hospital. "We believe that rapid identification of this bacterium will assist in timely initiation of antimicrobial therapy and admission to a setting where the patient is more appropriately observed based on his or her signs, symptoms and strain of bacteria causing the infection."

The technology revealed in this study can be integrated as a point-of-care device to help quickly detect and identify C. diff strains that pose significant health threats in hospitals and other health care settings.

According to the Centers for Disease Control and Prevention, the most serious C. diff cases are in the elderly and individuals with certain medical problems. C. diff spores can live outside the human body and may be transferred to bed linens, bed rails, bathroom fixtures and medical equipment, and other areas in the infected person's environment.

The incidence of C. diff has been on the rise and is increasing in severity and mortality in the U.S. and Europe. The cost of treating C. diff in the U.S. in 2008 topped $4 billion; and in 2006-07 it was responsible for an estimated 14,000 deaths in the U.S.

"With the emergence of a more severe C. diff strain (NAP1/027/B1), there is an urgent need for a highly sensitive and rapid method of detection and strain typing," Mermel said.

Current methods of diagnosing C. diff include stool cultures, toxin testing, enzyme immunoassays and polymerase chain reaction. While often effective, they may be impractical for use in an urgent care setting or emergency department where patients are presenting with gastrointestinal symptoms "The assay we have developed has the potential to quickly and accurately indicate the presence of specific markers of certain hypervirulent strains of C. diff," Mermel said. "We're confident this will lead to more timely, accurate diagnosis and treatment, with the hope that fewer patients will develop serious complications from this infection."


Contact: Ellen Slingsby

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Predictors identified for rehospitalization among post-acute stroke patients
3. More Smog Might Mean More Hospitalizations
4. After Hospitalization, Men More Likely to Show Up in ER
5. Choosing the right hospital may save your babys life
6. Heart Attack Survival Varies Widely Among Hospitals, Study Finds
7. In Some Brain Bleeds, Patients Do Better at High-Volume Hospitals
8. Rate of Hospitalizations for Stroke Has Declined in U.S.
9. Hospital readmission rates linked to availability of care, socioeconomics
10. Availability of Beds, Poverty Drive Costly Hospital Readmissions
11. Inhaled Steroids Lead to Big Drop in Asthma Deaths at Texas Hospital: Study
Post Your Comments:
(Date:11/24/2015)... , ... November 24, 2015 , ... In an ... restrictions and variables that determine which patients are or are not eligible for bariatric ... have a BMI over 40, are more than 100 pounds overweight, or have a ...
(Date:11/24/2015)... UT (PRWEB) , ... November 24, 2015 , ... It ... Magazine. For a business, it is critical that the first impression be positive and ... they are not likely to buy anything or want to return. They will also ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... gather to share their knowledge and experiences at a live taping of the ... Ruesch Center for the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Aided by ... today announced an innovative study designed to yield insights into how to detect and ... of biomarkers for pancreatic cancer from small, non-coding RNA molecules (ncRNA), genetic material that ...
(Date:11/24/2015)... ... November 24, 2015 , ... Sir Grout of Baltimore is ... certification. The award recognizes good companies for excellence in service and a commitment ... and hard surface restoration company earned this recognition after a thorough review by ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... NEWS, Va. , Nov. 24, 2015  DILON ... they have signed an agreement for DILON to distribute ... geographies across the globe. The signing of this distribution agreement ... Discovery NM750b Molecular Breast Imaging system and is considered ... to provide better healthcare solutions for clinicians and their ...
(Date:11/24/2015)... , Nov. 24, 2015 Avery Biomedical ... is pleased to announce the appointment of Anders ... Dr. Jonzon ... cardiology at Children,s Hospital, Uppsala University, Uppsala and Children,s ... 1984-1986, he was a fellow at the Cardiovascular Institute ...
(Date:11/24/2015)... LAUSANNE and BERN, Switzerland ... SA, the ARTORG Center for Biomedical Engineering Research of ... and the Division of Endocrinology, Diabetes and Clinical Nutrition ... announce the start of an exclusive collaboration to develop ... control algorithm for the personalised delivery of insulin for ...
Breaking Medicine Technology: