Navigation Links
RI Hospital: Co-infections not associated with worse outcomes during H1N1 pandemic
Date:4/9/2013

PROVIDENCE, R.I. A study at Rhode Island Hospital has found that despite complications, patients co-infected with the pandemic 2009-2010 influenza A H1N1 (pH1N1) and a second respiratory virus were not associated with worse outcomes or admission to the hospital's intensive care unit. The study is published online in the journal PLOS ONE.

"There is scant data in the literature regarding the incidence and impact of simultaneous infection by two respiratory viruses, particularly in adults," said senior investigator Leonard Mermel, D.O., medical director of the department of epidemiology and infection control at Rhode Island Hospital. "We compared 617 people hospitalized with respiratory infection due to a single virus to 49 people hospitalized with such infections due to two viruses (co-infection). Those with viral co-infection were younger, more often had fever/chills and shortness of breath than those with co-infection. Although patients with viral co-infection were more likely to be treated for a secondary bacterial pneumonia, they were not more likely to require ICU admission and they did not have a longer length of hospital stay."

The pandemic 2009-2010 influenza A (pH1N1) was first identified in the U.S. in April 2009 and infected patients across the country in two waves. There were an estimated 61 million cases of pH1N1; 274,000 hospitalizations; and 12,470 deaths associated with the pandemic -- a significant increase in hospitalizations, and a decrease in mortality as compared to seasonal influenza averages.

Children experienced a greater burden of disease than adults during the pandemic, with a higher mortality rate. However, despite fewer cases in adults, more adult patients were afflicted with serious illness. Children also had a higher rate of co-infection, which may be due to an absence of protective antibodies or other forms of immunity that older individuals have gained over time.

A previous study at Rhode Island Hospital compared patients with pH1N1 to those infected with other respiratory viruses. While patients with co-infections were excluded from the initial study, the current analysis focused on this patient population, and hypothesized that those with both pH1N1 and a respiratory virus would have worse outcomes than those with just one infection.

However, Mermel and his colleagues found that despite the risk for complications including treatment for a bacterial pneumonia, co-infection was, in fact, not associated with worse outcomes.

"Although by our measures there was no demonstration of worse outcomes, co-infected patients demonstrated a significant greater rate of patterns of viral pneumonia by chest radiographs," said principal investigator Ignacio A. Echenique, M.D., a former Rhode Island Hospital researcher who is now affiliated with Northwestern University. "These forms of pneumonia would not be expected to respond to antibiotics. Ultimately, the significance of the association of a co-infection with viral pneumonias is unclear. While hospitalized patients with respiratory virus co-infection did not experience poorer outcomes, our findings do not address whether co-infection is a risk factor for hospitalization itself."

The researchers concluded that a large, multi-center study should be conducted across various levels of care to measure the impact of co-infections on hospitalization, and to distinguish between viral and bacterial pneumonia in co-infected patients.


'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Related medicine news :

1. RI Hospital: Traumatic brain injury worsens outcomes for those with nonepileptic seizures
2. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
3. RI Hospital: Standardized road test results differ from older adults natural driving
4. RI Hospital: Near-complete blood flow restoration critical for best outcomes in stroke
5. Many Test Results Left Unread as Patients Leave Hospital: Study
6. Inhaled Steroids Lead to Big Drop in Asthma Deaths at Texas Hospital: Study
7. CAMH study shows mental illness associated with heavy cannabis use
8. Mindfulness from meditation associated with lower stress hormone
9. Associated Plastic Surgeons & Consultants Reports that Insurance Denied Payment for Bilateral Breast Reconstruction Following Mastectomy
10. d'Oliveira & Associates Releases New Byetta Infographic on Potential Kidney and Pancreas Health Risks Associated with the Drug
11. Depression in Alzheimers patients associated with declining ability to handle daily activities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... ... TherapySites, the leading website and online marketing ... Association. This new relationship allows TherapySites to continue to extend their online ... and promotional offers. , "TCA is extremely excited about this new partnership, as ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect Plugin ... whole new perspective by using the title layers in ProSlice Levels to split-up ... Levels contains over 30 Different presets to choose from. FCPX users can ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: