Navigation Links
RI Hospital: Co-infections not associated with worse outcomes during H1N1 pandemic
Date:4/9/2013

PROVIDENCE, R.I. A study at Rhode Island Hospital has found that despite complications, patients co-infected with the pandemic 2009-2010 influenza A H1N1 (pH1N1) and a second respiratory virus were not associated with worse outcomes or admission to the hospital's intensive care unit. The study is published online in the journal PLOS ONE.

"There is scant data in the literature regarding the incidence and impact of simultaneous infection by two respiratory viruses, particularly in adults," said senior investigator Leonard Mermel, D.O., medical director of the department of epidemiology and infection control at Rhode Island Hospital. "We compared 617 people hospitalized with respiratory infection due to a single virus to 49 people hospitalized with such infections due to two viruses (co-infection). Those with viral co-infection were younger, more often had fever/chills and shortness of breath than those with co-infection. Although patients with viral co-infection were more likely to be treated for a secondary bacterial pneumonia, they were not more likely to require ICU admission and they did not have a longer length of hospital stay."

The pandemic 2009-2010 influenza A (pH1N1) was first identified in the U.S. in April 2009 and infected patients across the country in two waves. There were an estimated 61 million cases of pH1N1; 274,000 hospitalizations; and 12,470 deaths associated with the pandemic -- a significant increase in hospitalizations, and a decrease in mortality as compared to seasonal influenza averages.

Children experienced a greater burden of disease than adults during the pandemic, with a higher mortality rate. However, despite fewer cases in adults, more adult patients were afflicted with serious illness. Children also had a higher rate of co-infection, which may be due to an absence of protective antibodies or other forms of immunity that older individuals have gained over time.

A previous study at Rhode Island Hospital compared patients with pH1N1 to those infected with other respiratory viruses. While patients with co-infections were excluded from the initial study, the current analysis focused on this patient population, and hypothesized that those with both pH1N1 and a respiratory virus would have worse outcomes than those with just one infection.

However, Mermel and his colleagues found that despite the risk for complications including treatment for a bacterial pneumonia, co-infection was, in fact, not associated with worse outcomes.

"Although by our measures there was no demonstration of worse outcomes, co-infected patients demonstrated a significant greater rate of patterns of viral pneumonia by chest radiographs," said principal investigator Ignacio A. Echenique, M.D., a former Rhode Island Hospital researcher who is now affiliated with Northwestern University. "These forms of pneumonia would not be expected to respond to antibiotics. Ultimately, the significance of the association of a co-infection with viral pneumonias is unclear. While hospitalized patients with respiratory virus co-infection did not experience poorer outcomes, our findings do not address whether co-infection is a risk factor for hospitalization itself."

The researchers concluded that a large, multi-center study should be conducted across various levels of care to measure the impact of co-infections on hospitalization, and to distinguish between viral and bacterial pneumonia in co-infected patients.


'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Related medicine news :

1. RI Hospital: Traumatic brain injury worsens outcomes for those with nonepileptic seizures
2. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
3. RI Hospital: Standardized road test results differ from older adults natural driving
4. RI Hospital: Near-complete blood flow restoration critical for best outcomes in stroke
5. Many Test Results Left Unread as Patients Leave Hospital: Study
6. Inhaled Steroids Lead to Big Drop in Asthma Deaths at Texas Hospital: Study
7. CAMH study shows mental illness associated with heavy cannabis use
8. Mindfulness from meditation associated with lower stress hormone
9. Associated Plastic Surgeons & Consultants Reports that Insurance Denied Payment for Bilateral Breast Reconstruction Following Mastectomy
10. d'Oliveira & Associates Releases New Byetta Infographic on Potential Kidney and Pancreas Health Risks Associated with the Drug
11. Depression in Alzheimers patients associated with declining ability to handle daily activities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... , ... “Epilepsy Awareness,” which can be found at the ... about epilepsy, bearing down on the social stigma and lack of public education ... within their lifetime. With such a large percentage of people affected, it’s critically ...
(Date:12/5/2016)... ... December 05, 2016 , ... Physicians Education Resource®, LLC (PER®) ... on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma, on February 24, 2017. ... to have Amy E. Herman present at this year’s conference, her unprecedented knowledge ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... ... gender, and geographic lines. The goal of Castlewood Treatment Centers has always been ... accessible to as many people as possible. In that spirit, Castlewood has ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one of New York ... participated in the 36th Annual Cutting Edge Aesthetic Symposium at the Waldorf Astoria in ... that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for his expertise in ...
(Date:12/5/2016)... ... 2016 , ... Sideline Products is a Southern York County Pennsylvania-based premier designer ... and the horse. Smaller saddles can pinch and irritate the horse creating safety issues ... properly fitted western saddle so it does not impact the comfort or performance of ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... BOCA RATON, Fla. , Dec. 5, ... Commercialization of Public Research (the Florida Institute) ... agreement SegAna, LLC, an Orlando ... Central Florida. The Florida Institute supports new company ... funding gaps for companies spinning out of Florida-based universities ...
(Date:12/5/2016)... Dec. 5, 2016  Breckenridge Pharmaceutical, Inc. announced ... marketing agreement with development and manufacturing partner Gland ... the terms of this agreement, Breckenridge will market ... the United States . The ... ANDA. The products cover a wide range of ...
(Date:12/5/2016)... 2016  Sharn Anesthesia Inc. announced today that it ... partner for Salter Labs.  The company also received the ... of outstanding sales performance. Salter Labs is ... care, including the market gold standard ECO 2 ... of the Parker Flex-Tip® Endotracheal Tube, which is a ...
Breaking Medicine Technology: