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RELAX-AHF shows first positive findings in HFpEF patients
Date:5/26/2013

ve findings in patients with acute heart failure and preserved ejection fraction, a large population with unmet treatment needs. Seralaxin is at least as effective in AHF patients with HFpEF for relieving dyspnea during the first 24 hours and had a similar effect on rehospitalisation and survival in HFrEF and HFpEF patients."

The Vildagliptin in Ventricular Dysfunction Diabetes (VIVIDD) trial investigated the effects of the DPP4 inhibitor vildagliptin in patients with type 2 diabetes and HFrEF (left ventricular ejection fraction [LVEF] <40%). It is the first study to test this class of anti-diabetes drugs in patients with heart failure.

Presenter Professor John McMurray (UK) said: "Diabetes and heart failure is a common dual problem and these patients have a particularly bad outlook. But, remarkably, patients with heart failure are excluded from most trials testing diabetes drugs. At the moment it's not at all clear how clinicians should choose between the various anti-diabetes drugs when confronted with a heart failure patient."

The primary objective of this randomised, double-blind, placebo controlled trial was to demonstrate that vildagliptin was non-inferior to placebo with respect to change in echocardiographic LVEF from baseline to 52 weeks. For the trial, 254 patients from 15 countries were randomised to 52 weeks treatment with placebo or vildagliptin 50mg bid.

The effect of vildagliptin on LVEF did not differ from placebo, confirming non-inferiority. But, unexpectedly, vildagliptin increased the size of the left ventricle with no decline in the contraction and emptying of the left ventricle and no change in B-type natriuretic peptide (BNP).

Professor McMurray said: "Normally an increase in the size of the left ventricle is associated with a decline in systolic function but we saw no change in ejection fraction and a fall rather than increase in BNP. We speculate that the surprising findings of VIVIDD indicate that
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Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

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