The Underlying Cause of Heart Attack, Stroke and PAD
Atherothrombosis occurs when a blood clot (thrombus) forms on a ruptured plaque (atheroma) in the wall of a blood vessel. Plaques consist of fatty acids and cholesterol, calcium and other materials.
The rupture of plaques and the subsequent development of a clot can cause partial or complete blockage of an artery in various parts of the body. When a vessel in the heart is partially or completely blocked by a clot the result can be a heart attack. In the brain, the same process can cause a stroke. Elsewhere in the body, this process can lead to reduction or blockage of blood flow in the arteries of the legs - PAD - a significant risk factor for heart attack or stroke.
Atherothrombosis is thus the common thread linking heart attack, stroke and peripheral arterial disease.
Notes to Editors:
The REACH Registry is the first outpatient registry to characterize real- world event rates and treatment patterns in a broad spectrum of patients with atherothrombosis worldwide. The Registry follows more than 60,000 patients over 4 years, involving 44 countries and 5,000 physician investigators. The REACH Registry aims to improve the assessment and management of patients with a history of coronary artery disease (CAD), cerebrovascular disease (Stroke/TIA), peripheral arterial disease (PAD), and those with a combination of high risk factors.
The REACH Registry is sponsored by Sanofi-Aventis, Bristol-Myers Squibb, and the Waksman Foundation (Tokyo, Japan), who assisted with the design and conduct of the study and data collection.
The REACH Registry is endorsed by the World Heart
|SOURCE REACH Registry|
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