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RANK protein promotes the initiation, progression and metastasis of human breast cancer
Date:4/24/2012

ng pathway may be associated with an increased initiation, progression and metastasis of breast cancer."

Clinic applications

The next step, according to researcher Eva Gonzalez-Suarez, would be "first, confirm these studies with a larger number of samples and secondly explore the therapeutic possibilities."

As explained Gonzalez-Suarez, "there is a theory which says that chemotherapy treatments kill tumour cells but do not affect cancer stem cells, which could reinitiate the tumour after treatment. If indeed this pathway has the ability to restart the tumours and metastatic capacity increase, a combination of RANK inhibitor with chemotherapy may have important therapeutic effects. "

Currently, there is a pharmacological inhibitor of RANK signalling pathway used in clinics, in the treatment of osteoporosis and bone metastases.


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Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

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