Navigation Links
RANK protein promotes the initiation, progression and metastasis of human breast cancer
Date:4/24/2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research.

RANK signalling pathway

The study was coordinated by Eva Gonzalez-Suarez, head of the IDIBELL research group on Transformation and Metastasis. A year ago, the team published a paper which showed that this pathway is also relevant in breast tumours in mouse models. "We saw that when this pathway is overactive, animals were more susceptible to developing breast cancer and that tumours decreased when we pharmacologically inhibited the pathway" (Gonzalez-Suarez et. Al. Nature 2010).

The starting point of this study was to observe the effect in humans of overexpression of RANK. First, the researchers used healthy mammary epithelial cell lines and found that "RANK receptor overexpression induces characteristics of stem cells and epithelial-mesenchymal transition to our cells, taking on characteristics of malignancy but without developing tumours."

The next step was to observe the effects of protein overexpression in breast tumour cells. "We saw how it generated an increasing in tumour stem cells, and when we injected it in animal models, tumourogenesis and metastasis increased."

Finally, they used clinical samples of breast tumours. Cancer cells with high levels of RANK were associated with basal type tumours, high-grade tumours, and more aggressive ones with more proliferation and metastasis. This means that "high levels of protein are associated with poor prognosis tumours."

Therefore, this study corroborates in human cells what it had already been seen in mice, "an increasing in the activation of the RANK signalli
'/>"/>

Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Thousand of GranuFlo lawsuits ... recalled its GranuFlo and NaturaLyte dialysis concentrates continue to ... U.S. District Court, District of Massachusetts, Bernstein Liebhard LLP ... Court has remanded a case filed by the state ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of ... area has treated just about every type of injury that can ... for those same twenty-plus years, the team at Doctors on ... the best possible doctor. With the combined breadth of ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television ... 32nd Annual Miami Breast Cancer Conference planned ... (PER®) , shares that “a fast-growing, virulent” cancer in ... had not followed up her clean mammogram with an ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... American Diabetes Association , ... Welch, Minn. (Vocus) May ... the serious health issues that are associated with diabetes. Type 2 ... those who are 19 years and older. Diabetes has reached epidemic ...
... job loss has impacted most people in every socio-economic ... stimulus combo-packages on BOTOX® Cosmetic and fillers, like Restylane ... feel at the top of their game, improve self ... market and erase unwanted worry lines and reflections of ...
... a Series of Community Discussions on Improving Access to ... Teva Pharmaceuticals USA, the leading generic pharmaceutical company, today ... as part of their Year of Affordable Healthcare campaign ... the YMCA San Francisco, aimed at raising awareness of ...
... Directed Verdict that Rescission was ProperSAN FRANCISCO, May 28 ... General Counsel Seth Jacobs:Today,s verdict is a complete vindication for ... every step of the way. It means that our ... and we acted in good faith. There was no ...
... Inc. (NYSE: DVA ) announced today ... the Company,s Board of Directors. (Logo: ... former President of American Express International, Japan, Asia-Pacific, ... the Consumer Card business across 12 countries, heading ...
... May 28 The London Fire Department has ... breathing apparatus and monitoring systems. Representing a ... largest firefighting service, the order also reflects a ... work closely together to ensure even greater protection ...
Cached Medicine News:Health News:Prairie Island Indian Community Supports Fight Against Diabetes Locally and Nationally 2Health News:Infini Cosmetic Associates Offers Boomer Stimulus Packages to Offset Aging and Help Job Seekers Get a Fresh Start 2Health News:Infini Cosmetic Associates Offers Boomer Stimulus Packages to Offset Aging and Help Job Seekers Get a Fresh Start 3Health News:The Year of Affordable Healthcare Brings Together San Francisco Community Groups to Tackle Healthcare Crisis 2Health News:Pamela M. Arway Joins DaVita Board of Directors 2Health News:London, England Fire Department Places Major Order with Draeger 2
(Date:1/23/2015)... N.Y. , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. ... its Phase I trial of Lixte,s lead compound, LB‑100, is ... John S. Kovach , M.D., the founder ... planned to be completed at a single site. Accrual of ...
(Date:1/23/2015)... 23, 2015   Leatt Corporation  (OTCQB: LEAT), a global ... all forms of sports, including extreme motor sports, and ... today that the UISP Lega Motociclismo Lombardia, an Italian ... to wear a neck brace during its racing competitions.  ...
(Date:1/23/2015)... (NYSE: MNK ) announced today that its ... The open-ended authorization permits the company to repurchase up ... "Funding additional initiatives and seeking attractive business ... pursue a range of focused growth strategies," said ...
Breaking Medicine Technology:Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... NEWTON, Mass. , Aug. 5 Microfluidics International Corporation (OTC Bulletin Board: ... on Tuesday, August 10, 2010 , at 8:30am ET . , ... (Logo: http://photos.prnewswire.com/prnh/20090811/NE59652LOGO ) , , ... ) , , , ...
... 5 Cornerstone Therapeutics Inc. (Nasdaq: ... specialty pharmaceutical company focused on acquiring, developing and commercializing ... today announced that its product candidate CRTX-067 is an ... mg hydrocodone polistirex suspension product that will be a ...
Cached Medicine Technology:Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 2Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 3Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 4Cornerstone Therapeutics Announces Development of Generic for Tussionex® 2Cornerstone Therapeutics Announces Development of Generic for Tussionex® 3
As with all Eschmann products the T20 operating table was designed with 'Simplicity and Intuitiveness' in mind, having drawn influences from leading clinicians of various levels from across the globe...
... carbon fiber c-arm table allows 50 ... brachytherapy, gynecology, gastroenterology, cardiovascular, orthopedic, ENT, ... design allows easy access for all ... 16-inch elevating travel, 16-inch longitudinal travel, ...
... imaging table is a fully digital imaging ... and advanced patient data management system. The ... the industry providing unsurpassed access for both ... to either a right- or left- hand ...
... Designed for procedures where stability, ... are essential. A cantilevered low attenuation ... ceiling-suspended C-Arms. The radiolucent area is ... fluoroscopic visualization and unobstructed C-Arm positioning. ...
Medicine Products: