Navigation Links
RANK protein promotes the initiation, progression and metastasis of human breast cancer
Date:4/24/2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research.

RANK signalling pathway

The study was coordinated by Eva Gonzalez-Suarez, head of the IDIBELL research group on Transformation and Metastasis. A year ago, the team published a paper which showed that this pathway is also relevant in breast tumours in mouse models. "We saw that when this pathway is overactive, animals were more susceptible to developing breast cancer and that tumours decreased when we pharmacologically inhibited the pathway" (Gonzalez-Suarez et. Al. Nature 2010).

The starting point of this study was to observe the effect in humans of overexpression of RANK. First, the researchers used healthy mammary epithelial cell lines and found that "RANK receptor overexpression induces characteristics of stem cells and epithelial-mesenchymal transition to our cells, taking on characteristics of malignancy but without developing tumours."

The next step was to observe the effects of protein overexpression in breast tumour cells. "We saw how it generated an increasing in tumour stem cells, and when we injected it in animal models, tumourogenesis and metastasis increased."

Finally, they used clinical samples of breast tumours. Cancer cells with high levels of RANK were associated with basal type tumours, high-grade tumours, and more aggressive ones with more proliferation and metastasis. This means that "high levels of protein are associated with poor prognosis tumours."

Therefore, this study corroborates in human cells what it had already been seen in mice, "an increasing in the activation of the RANK signalling pathway may be associated with an increased initiation, progression and metastasis of breast cancer."

Clinic applications

The next step, according to researcher Eva Gonzalez-Suarez, would be "first, confirm these studies with a larger number of samples and secondly explore the therapeutic possibilities."

As explained Gonzalez-Suarez, "there is a theory which says that chemotherapy treatments kill tumour cells but do not affect cancer stem cells, which could reinitiate the tumour after treatment. If indeed this pathway has the ability to restart the tumours and metastatic capacity increase, a combination of RANK inhibitor with chemotherapy may have important therapeutic effects. "

Currently, there is a pharmacological inhibitor of RANK signalling pathway used in clinics, in the treatment of osteoporosis and bone metastases.


'/>"/>
Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
Breaking Medicine Technology: