Navigation Links
RANK protein promotes the initiation, progression and metastasis of human breast cancer
Date:4/24/2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research.

RANK signalling pathway

The study was coordinated by Eva Gonzalez-Suarez, head of the IDIBELL research group on Transformation and Metastasis. A year ago, the team published a paper which showed that this pathway is also relevant in breast tumours in mouse models. "We saw that when this pathway is overactive, animals were more susceptible to developing breast cancer and that tumours decreased when we pharmacologically inhibited the pathway" (Gonzalez-Suarez et. Al. Nature 2010).

The starting point of this study was to observe the effect in humans of overexpression of RANK. First, the researchers used healthy mammary epithelial cell lines and found that "RANK receptor overexpression induces characteristics of stem cells and epithelial-mesenchymal transition to our cells, taking on characteristics of malignancy but without developing tumours."

The next step was to observe the effects of protein overexpression in breast tumour cells. "We saw how it generated an increasing in tumour stem cells, and when we injected it in animal models, tumourogenesis and metastasis increased."

Finally, they used clinical samples of breast tumours. Cancer cells with high levels of RANK were associated with basal type tumours, high-grade tumours, and more aggressive ones with more proliferation and metastasis. This means that "high levels of protein are associated with poor prognosis tumours."

Therefore, this study corroborates in human cells what it had already been seen in mice, "an increasing in the activation of the RANK signalling pathway may be associated with an increased initiation, progression and metastasis of breast cancer."

Clinic applications

The next step, according to researcher Eva Gonzalez-Suarez, would be "first, confirm these studies with a larger number of samples and secondly explore the therapeutic possibilities."

As explained Gonzalez-Suarez, "there is a theory which says that chemotherapy treatments kill tumour cells but do not affect cancer stem cells, which could reinitiate the tumour after treatment. If indeed this pathway has the ability to restart the tumours and metastatic capacity increase, a combination of RANK inhibitor with chemotherapy may have important therapeutic effects. "

Currently, there is a pharmacological inhibitor of RANK signalling pathway used in clinics, in the treatment of osteoporosis and bone metastases.


'/>"/>
Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... , ... February 12, 2016 , ... Donor Network West, ... California and Nevada, announced a partnership with San Ramon Regional Medical Center. Under the ... hospital’s facilities as a way to accommodate a more certain time frame for donor ...
(Date:2/12/2016)... ... February 12, 2016 , ... For Coast Dental dentist ... Sweeney, RDH, and dental assistant Terrell Moore shortly before 7 a.m. to volunteer at ... dental professionals, donating their time and skills to help hundreds of uninsured and underinsured ...
(Date:2/12/2016)... New York, NY (PRWEB) , ... February 12, ... ... latest edition of “Revolutionizing Cancer Care.” , The print component of ... in Chicago, Dallas, Pittsburgh/Cleveland, New York, Washington DC/Baltimore, and Seattle, with a circulation ...
(Date:2/12/2016)... ... February 12, 2016 , ... Atlantic Information Services, Inc. ... and PBMs,” an upcoming Feb. 24 webinar that will discuss ways health plans ... categories, such as the $1,000-per-pill hepatitis C treatment Sovaldi and high-cost PCSK9 inhibitors ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... US ... Des Moines, Iowa. Legacy Golf Club, located in Norwalk, serves as the host site ... the Year, Rob Randall. , “We have had successful camps in recent years around ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Hypermarcas S.A. ("Hypermarcas") today announced that ... "Tender Offer") to purchase any and all of ... its 6.500% Senior Notes due 2021 (CUSIP Nos. ... "Notes"). In connection with the Tender Offer, Hypermarcas ... "Consents") of the holders of the Notes (the ...
(Date:2/12/2016)... 12, 2016 ... http://www.sedar.com ) und der ... abrufbar.    --> http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... seinen Konzernabschluss des zweiten Quartals und ...
(Date:2/12/2016)... -- Memorial Hermann Health System has teamed up with Houston ... a one-of-a-kind experience to pediatric patients at Children,s ... 360-degree video and Google Cardboard, Howard was able to ... the patients and their families an unexpected, and energetically ... video . Memorial Hermann IRONMAN Sports ...
Breaking Medicine Technology: