Navigation Links
Quitting smoking can reverse asthma-inducing changes in lungs
Date:12/7/2009

Asthmatic smokers may be able to reverse some of the damage to their lungs that exacerbates asthmatic symptoms just by putting down their cigarettes, according to research out of the University of Groningen in the Netherlands.

The research is published in the December 15 issue of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"We found that exposure to cigarette smoke appears to increase the thickness of the epithelium, or lining, of the airways in the lung. This may be the underlying cause of the fact that smoking asthma patients experience more asthma symptoms, such as shortness of breath and phlegm production, compared to non-smoking asthma patients," said Martine Broekema, Ph.D., the lead author of the study.

Dr. Broekema and colleagues examined patients with asthma who were assessed each for the severity of their asthma and allergy, given questionnaires to determine the extent of their smoke-induced symptoms, and then underwent bronchial biopsies. Of the total of 147 patients, 66 never smoked, 46 were ex-smokers and 35 were current smokers.

In addition to the changes in the epithelial thickness, Dr. Broekema found distinct differences between the current smokers and the ex- and non-smokers. "In addition to the epithelial thickening, we found that cigarette smoke negatively affects levels of exhaled nitric oxide, making it an unreliable indicator of asthma severity in smokers," she said.

Current smokers also had more mucous-producing goblet cells in their epithelium and, the epithelial cell layer contained more mucus protein overall, when compared to never-smoking asthmatics. "These pathological findings were associated with the severity of phlegm production reported by the asthma patients, suggesting a causal relationship between the two. Smoking asthmatics also showed a distinct inflammatory profile in their lungs compared to never-smoking asthmatics, with a lower number of eosinophils and higher number of mast cells," said Dr. Broekema. "Furthermore, our data suggest that smoking cessation can reverse the thickening of the lining of the airways."

To determine the role of exposure length on asthmatic lungs, the scientists divided the ex-smokers into two groups: those with fewer than the median 3.4 pack-year exposure and those with more than 3.4 pack-years.

Interestingly, while they expected to find evidence of a dose-response effect between smoking and epithelial remodeling, no such association was apparent between the number of pack-years or duration of smoking cessation and epithelial remodeling.

"To our surprise, these two sub-groups of ex-smokers showed no difference in any outcome measure. These sub-analyses indicate that the amount of smoke exposure in the past does not influence our outcome measures," said Dr. Broekema. "This study shows again how important smoking cessation is for pulmonary health, and this appears to be especially true for asthmatic patients. The good news is that quitting appears to have a measurable benefit in these individuals."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Switch to Light Cigarettes Makes Quitting Tougher
2. Nicotine Patch Plus Lozenge Best for Quitting Smoking
3. Scientist at The Fienstein Instute for Medical Research Discovers Quitting Smoking Promotes Anti-Inflammatory Response
4. First brain study reveals benefits of exercise on quitting smoking
5. Quitting Smoking Tougher on Women
6. Quitting Smoking Can Be a Parents Best New Years Resolution
7. Quitting Smoking Saves Lives and Money: New American Lung Association Report Finds Most States Failing to Adequately Protect Residents and Their Bottom Line
8. Trouble quitting?: A new Pitt-Carnegie Mellon smoking study may reveal why
9. Quitting Isnt That Easy
10. Genes May Play Role in Quitting Smoking
11. MultiVu Video Feed: FREE NICOTINE REPLACEMENT THERAPY (NRT) TO BE OFFERED TO REGISTERED PILOTS INTERESTED IN QUITTING RELIEF IN LIGHT OF RECENT FAA RULINGS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... services with or without a referral to new patients from Burnaby, BC. Patients ... or other full mouth reconstruction services, can see the esteemed team at Wall ...
(Date:3/29/2017)... ... March 29, 2017 , ... Patients interested in receiving ... from Dr. Jamie Cameron, with or without a referral. The FASTBRACES system is ... Depending on each patient’s case, treatment with the FASTBRACES system could be completed ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... it continues developing an ANSI-approved, consensus-based American National Standard for Good Manufacturing ... publish the first ANSI-approved GMP standard for dietary supplements this spring, is ...
(Date:3/29/2017)... ... 29, 2017 , ... Altima Technologies, Inc., the maker of ... center assets and audio-video devices has recently updated its Visio Stencils library with ... and download shapes and stencils from http://www.VisioStencils.com. , New devices were ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... oral braces. "The rubber bands used in conjunction with my braces always rubbed ... to design a way to prevent this problem." The O.B.S. was the result ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 29, 2017  Designers of primary cell wearable medical ... by 50% and extend battery life with the MAX20310 ... circuit (PMIC) from Maxim Integrated Products, Inc. (NASDAQ: ... input voltage of just 0.7V for new high-energy density ... as well as the more common Alkaline battery architecture. ...
(Date:3/29/2017)... , USA, March 29, 2017 Stryker ... that Cares by People magazine, in partnership with Great ... 50 companies on the list. This list highlights the ... have succeeded in business while also demonstrating respect, compassion ... environment.  To determine the companies on ...
(Date:3/29/2017)... March 29, 2017 /PRNewswire/ - Medicure Inc. ("Medicure") (TSXV:MPH, ... results for the year ended December 31, 2016 ... The results are being released later than the ... will include the operations and balances of Apicore ... This release and filing date meets TSX Venture ...
Breaking Medicine Technology: