Navigation Links
Quintet of proteins forms new, early-warning blood test before heart attack strikes
Date:11/9/2008

(Sunday Morning Program, Presentation #183, Room #283-285, Ernest N. Morial Convention Center)

A team of Johns Hopkins biochemists has identified a mixed bag of five key proteins out of thousands secreted into blood draining from the heart's blood vessels that may together or in certain quantities form the basis of a far more accurate early warning test than currently in use of impending heart attack in people with severely reduced blood flow, or ischemia.

The work, involving more than a dozen scientists and taking more than a year to perform, is believed to be the largest protein analysis ever done at Hopkins. It was based on 76 arterial blood samples from 19 men and women taken immediately before and after a period of medically induced ischemia lasting as long as 45 minutes.

All had ischemia induced through accelerated pacing of the heart's main chambers. Blood samples were provided by cardiologists at the University of Texas Southwestern.

Key to the researchers' selection criteria for which proteins to analyze from among tens of thousands in the blood was what they call "a pipeline approach."

"From the start, we knew that we were looking for rare, almost unique biomarkers that bore some direct relationship with ischemia," says study senior investigator Jennifer Van Eyk, Ph.D., whose first step was to remove from the analysis common blood proteins, such as albumin and globulins. That left batches of 400 proteins for in-depth measure of any changes before and after ischemia.

Their analysis, to be presented Nov. 9 at the at the American Heart Association's (AHA) annual Scientific Sessions in New Orleans, found that only the five proteins were present in significantly increased amounts after ischemia occurred, with at least a doubling in the blood concentration, compared with those recorded during healthy blood flow. These were lumican, semenogelin, angiogenin, extracellular matrix protein, and
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Heat shock proteins are co-opted for cancer
3. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
4. Immune Proteins Warn of Early Lung Cancer
5. 2 proteins may be survival markers in some breast cancers
6. Scientists get first look at how water lubricates proteins
7. New Proteins That Help HIV Grow Identified
8. The Handbook of Proteins
9. Chopped up proteins trigger autoimmunity
10. Oncoproteins double-team and destroy vital tumor-suppressor
11. 3 newly discovered ERK pathway proteins related to CagA induced disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013 The Rottenstein Law ... firm, has created the Tylenol Lawsuit Information Center at ... Tylenol users and those who are considering filing lawsuits. ... to potentially cause severe liver damage, according to a ... In the “safety communication,” the FDA warned consumers ...
(Date:5/23/2013)... Former United States Vice President Dick Cheney served ... Paramedic Luncheon. , In front of 1,500 guests ... medics, saying, "I am delighted to be here to ... of the Year Award. I think it's a tremendous ... within a company like this because there are obviously ...
(Date:5/23/2013)... York, NY (PRWEB) May 23, 2013 ... , Canadian tech start-ups are increasingly seeing their ... deals with larger US-based companies, according to new ... development engine. , The company has compiled its ... Borderless Investments. The findings of the research have shown ...
(Date:5/23/2013)... 2013 Parker Waichman LLP, a national ... injured by defective medical devices and drugs, is proud ... has been appointed Co-Lead Counsel in the Mirena IUD ... Litigation (Case 7:13-md-02434-CS). The Order, which was filed on ... to submit their proposal for the Court’s appointment of ...
(Date:5/23/2013)... Schools should ensure that kids get at least ... support their health and boost performance in school, ... previous studies show 60 minutes of vigorous to ... estimated that only about 50 percent of school-aged ... the report from the Institute of Medicine. ...
Breaking Medicine News(10 mins):Health News:Rottenstein Law Group LLP Now Accepting Tylenol Cases, Announces New Tylenol Lawsuit Information Center 2Health News:Acadian Ambulance Honors Paramedic of the Year at Annual Luncheon 2Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 2Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 3Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 4Health News:U.S. District Court Appoints Parker Waichman LLP’s Matthew J. McCauley to Leadership Role in Mirena IUD Litigation 2Health News:U.S. School Kids Should Get Hour of Exercise Daily: Report 2
... because of cost , , FRIDAY, May 30 (HealthDay News) -- ... in 2006, so 38 percent of high school graduates and ... in the year after graduation, a new report shows. , ... done the study, the number of uninsured has grown," said ...
... Completed, WASHINGTON, May 30 The Department of,Veterans ... to,veterans potentially identified as being ill or injured from ... begin targeting over 500,000 OEF-OIF veterans who have been,discharged ... health care., "We promised to reach out to ...
... 30 On June 5th at the annual ... vote for the,second year on a shareowner proposal ... The resolution received 42% last year., Walden ... on,integrating environmental, social and governance factors into the,investment ...
... be a good investment for the health, according to a ... death rate for golfers is 40 per cent lower than ... status, which correspond to a 5 year increase in life ... , It is a well-known fact that exercise is good ...
... German . , Viruses are true experts ... organism. This trait is now being exploited for gene therapy, ... patient to treat genetic diseases or genetic defects. Korean researchers ... journal Angewandte Chemie, they have been able to use it ...
... 38 Fule,Health & Advisory, LTD ("38 Fule", or ... has begun trading on the OTC market,s highest,tier, ... premier trading,quotation and disclosure venue for over-the-counter securities ... have reliable information and,disclosure., "As a member ...
Cached Medicine News:Health News:More Young People Going Without Health Insurance 2Health News:More Young People Going Without Health Insurance 3Health News:VA Begins Next Phase of Combat Vet Outreach 2Health News:Golf prolongs life 2Health News:Self-assembled viruses 2Health News:Xi'an 38 Fule Health & Advisory, LTD Lists on International OTCQX 2
(Date:5/23/2013)... May 23, 2013  Hadasit Bio-Holdings Ltd. (TASE: HDST, ... companies, based on intellectual property developed and owned ... ,s foremost medical research center, today announced that ... significant funding from the Israeli Ministry of Industry ... to support product development and advance clinical trials. ...
(Date:5/23/2013)... 23, 2013 Anthem Blue Cross patients with ... required them to obtain their medications by mail order ... Whatley Kallas LLC.  The lawsuit, filed ... Blue Cross,s mandatory mail order program announced late last ... privacy. "This settlement brings to a close ...
(Date:5/23/2013)... , May 23, 2013  Hologic, Inc. (Hologic ... a leading developer, manufacturer and supplier of premium ... an emphasis on serving the healthcare needs of ... study in a U.S. clinical practice comparing breast ... tomosynthesis) with conventional 2D mammography alone showed a ...
Breaking Medicine Technology:Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 2Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... a new market research report is available in its catalogue: , ... Western European Disinfectant Gels and Scrubs Market , ... http://www.reportlinker.com/p0239932/Western-European-Disinfectant-Gels-and-Scrubs-Market.html , , , ... and scrubs market in western Europe , covering the United Kingdom , ...
... N.C. , July 19 Allscripts (Nasdaq: ... system in western North Carolina , has selected Allscripts Electronic ... its 60 employed physicians.  MedWest is also planning to host and deliver ... it serves. , , , ...
Cached Medicine Technology:Reportlinker Adds Western European Disinfectant Gels and Scrubs Market 2Reportlinker Adds Western European Disinfectant Gels and Scrubs Market 3Reportlinker Adds Western European Disinfectant Gels and Scrubs Market 4Reportlinker Adds Western European Disinfectant Gels and Scrubs Market 5Reportlinker Adds Western European Disinfectant Gels and Scrubs Market 6MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 2MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 3MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 4MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 5MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 6MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 7MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 8MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 9MedWest Health System Selects Allscripts Electronic Health Record and Practice Management for Employed Physicians 10
... Pipette is a synonym for pipetting accuracy, ... design, and superior operating comfort. Its single, ... measuring stroke and blow-out as well as ... ensures utmost accuracy and precision. Ejection sleeve ...
... new Finnpipette Focus from Thermo ... combine ergonomics with uncompromising performance. ... plate offers a custom fit ... new shorter tip cones allow ...
... The new Finnpipette Focus from ... to combine ergonomics with uncompromising ... handle plate offers a custom ... The new shorter tip cones ...
... The microprocessor controlled, Blanketrol II ... system provides effective patient warming ... system! The Blanketrol II offers ... flow rates of any hyper-hypothermia ...
Medicine Products: