Navigation Links
Questions Continue About Using Beta Blockers Before Surgery
Date:10/20/2008

Study finds increased risk of death, heart attacks

MONDAY, Oct. 20 (HealthDay News) -- A new study adds to doubts about using beta blockers to reduce the risks of surgery.

The death rate for people given beta blockers before non-cardiac surgery was 10 times higher in the 30 days after an operation than for those not getting the drugs (2.52 percent vs. 0.25 percent), according to a report in the October issue of the Archives of Surgery. The incidence of heart attacks was four times higher (2.94 percent vs. 0.74 percent).

"This is very much in line with the latest publications showing that one has to be very careful in using them," said study co-author Dr. Kamal Itani, chief of surgery at the Veterans Affairs Boston Health Care System and a professor of surgery at Boston University.

Beta blockers are commonly given before surgery to reduce cardiac risk by slowing the heartbeat. The Boston study found that the risk of problems was concentrated in those whose heart rates remained high despite beta-blocker treatment.

The new results differ somewhat from those of a major international study reported earlier this year. The POISE study of 8,351 people having non-cardiac surgery found a 27 percent reduction in heart attacks but an overall 33 percent higher death rate for those getting beta blockers.

Despite those results, beta blockers do have a role in surgery, Itani said. "I think we have to be careful about which patients receive beta blockers," he said. "There are clearly benefits for those drugs in patients at the highest risk of complications and with risk factors for heart disease."

The important point is to be sure that the target heartbeat rate is achieved, Itani said. The American College of Cardiology recommends 50 beats to 60 beats per minute before surgery, not to exceed 80 beats per minute, he noted.

"Those patients who do not have the target rate going into surgery will not do as well," Itani said. "Giving the drugs without achieving the full potential might be dangerous."

But the study indicates that the guidelines "need to be revisited," said Dr. Jeffrey H. Peters, chief of surgery at the University of Rochester, New York.

"This paper adds to a growing body of evidence suggesting that the routine use of beta blockers to reduce cardiac morbidity in surgery needs to be reconsidered," Peters said.

Unlike the POISE study, which was carefully designed with controls built in, the Boston study was retrospective, comparing 238 people given beta blockers before surgery with 480 who underwent surgery at the same center without being given the drugs, Peters noted.

"This is a retrospective study that is far from definitive, but it suggests that we should reconsider," he said.

"We recommend beta blockers for high risk patients, but we currently use them less and less," Peters said. He does not give beta blockers before surgery to people with no major risk factors for heart disease, such as diabetes or high blood pressure, he said.

Another paper published in the Oct. 28 issue of the Journal of the American College of Cardiology raises doubts about the use of beta blockers to control high blood pressure.

Analysis of data from nine controlled trials found a higher incidence of deaths, heart attacks, strokes and heart failure for people whose heart rate was lowered by beta-blocker treatment, said the report from cardiologists at Columbia University College of Physicians and Surgeons.

More information

Learn why and how beta blockers are used from the Texas Heart Institute.



SOURCES: Kamal Itani, M.D., professor, surgery, Boston University; Jeffrey H. Peters, M.D., chief, surgery, University of Rochester, N.Y.; October 2008, Archives of Surgery, Oct. 28, 2008, Journal of the American College of Cardiology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Susan G. Komen for the Cure(R) Advocacy Alliance Suggests Questions for Vice Presidential Debate
2. New Questions Raised About Lung Cancer Screening
3. Pediatrichealthchannel.com - New Site for Parents Seeking Answers to Children's Health Questions
4. On the Third Anniversary of Hurricane Katrina; Trust for Americas Health Questions State of National Emergency Preparedness
5. NJHA Raises Questions Regarding Horizons Proposal to Convert to For-Profit Health Insurer
6. Summer Games Swap Raises Questions About Image, Oral Health
7. Ten Questions to Ask When Considering COBRA Following a Disability
8. Why Do Drugs Cost So Much? and why are we so darn sick?: New Book Reveals Inner Workings of Big Pharma, Asks Hard Questions About Our Health
9. Major Union Questions PA Pension Fund, Calls on PSERS to Protect Workers, Retirees
10. New URAC Issue Brief Answers Questions About Delegated Credentialing, Transparency in Physician Tiering Programs
11. Edwards Lifesciences Receives Additional Questions From the FDA About the LifeStent Product Line
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Questions Continue About Using Beta Blockers Before Surgery
(Date:2/8/2016)... KS (PRWEB) , ... February 08, 2016 , ... TopConsumerReviews.com ... leader in Mole removal products. , Moles are derived from a cluster of melanin ... in all the wrong places and create a lifetime of embarrassment. Historically, mole ...
(Date:2/8/2016)... ... 08, 2016 , ... According to research by the National ... technicians to be certified or obtain continuing education. To increase patient awareness of ... Your Mouth?” campaign to inform dentists and patients about the possible lack of ...
(Date:2/7/2016)... ... February 07, 2016 , ... ... Plastics, has added Kybella® to his medical and surgical expertise. Technically known as ... FDA injectable medication used as a non-surgical alternative for reduction of fat below ...
(Date:2/6/2016)... St. Petersburg, FL (PRWEB) , ... February 06, 2016 , ... ... AsSeenOnTV.pro are pleased to announce the launch of a new DRTV campaign with Belly ... rug. If having tried everything from sprays to puppy pads and find nothing works, ...
(Date:2/5/2016)... ... 05, 2016 , ... VeloReality President and co-founder ... LYNX VR Indoor Trainer with multi-rider capability to an enthusiastic audience at the ... reduce the weight of the unit, they also enhance the rider's experience with ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 4, 2016  The Senior Care Pharmacy Coalition ... Committee Chairman Jason Chaffetz (R-UT) and ... hearing , "Developments in the Prescription Drug ... growing questions about abusive pharmacy benefit manager (PBM) ... and Ranking Member Elijah Cummings (D-MD) are diligent, ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... in the United States District Court for the District of ... (the "Class") consisting of all persons or entities who purchased ... (NASDAQ: INSY ) from March 3, 2015 through January ... certain of its officers with violations of the Securities Exchange ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... Summary Global Markets Direct,s, ,Wegener Polyangiitis - ... the Wegener Polyangiitis,s therapeutic pipeline. This report ... Wegener Polyangiitis, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ...
Breaking Medicine Technology: