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Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service
Date:6/1/2009

s manufactures the InSure(R) fecal immunochemical test (FIT), an FDA-cleared FOBT test for use in screening for sources of lower gastrointestinal bleeding, based on laboratory testing of a stool-based specimen. Quest Diagnostics is also developing a molecular blood test based on Epigenomics AG's Septin 9 DNA methylation biomarker that can help physicians detect colorectal cancer based on a patient's blood specimen.

About Cellular Pathways

Within each human cell, genes, lying adjacent to one another, form the basis for a pathway on which proteins cascade and signal the genes to perform tasks influencing cellular growth, death and proliferation. In some cancers, including mCRC, receptors of the epidermal growth factor protein that reside on each cell are abnormally activated, prompting a cascade effect across a cellular pathway and the potential for cancerous cellular proliferation. Anti-EGFR therapies interfere with the cell's epidermal growth factor receptor to impede cellular proliferation and prompt tumor cell death.

RAS is a family of genes encoding proteins that are involved in transmitting signals that influence cell growth and survival. Mutations in the RAS family of cancer-promoting oncogenes, which include KRAS and NRAS, are implicated in several cancers, including colorectal cancer. BRAF is an oncogene of RAF, which is a family of proteins typically activated by RAS and which influence cellular activity.

About Quest Diagnostics

Quest Diagnostics is the world's leading provider of diagnostic testing, information and services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic testing services through its network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in
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SOURCE Quest Diagnostics Incorporated
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