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Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service
Date:6/1/2009

followed by NRAS and BRAF. If a mutation is identified before the entire series is analyzed, the reflex testing process stops, and the test result is provided to the physician. Since any individual patient is only likely to experience one mutation in either KRAS, NRAS and BRAF, combined testing for mutations from these three genes in the EGFR pathway would theoretically accurately classify more patients as non-responders than KRAS and/or BRAF testing alone.

"While KRAS mutation analysis of codons 12 and 13 is well established as an aid in predicting anti-EGFR therapy response, a growing body of research has revealed that other mutations in the EGFR signaling pathway, including those at codon 61 of KRAS and NRAS, also impede treatment response in patients with mCRC," said Jay G. Wohlgemuth, M.D., vice president, Science and Innovation, Quest Diagnostics. "Our new test will enable physicians to gain a deeper understanding of a patient's EGFR pathway status, based on the latest scientific research, than is available using competing tests. We believe this test is an important diagnostic advance that will help physicians potentially identify more non-responder EGFR patients who might be missed using standard KRAS assessments, potentially sparing a substantial number of patients lost time, not to mention side effects and high costs of anti-EGFR therapies."

In addition to the EGFR Pathway Test, the company launched individual laboratory tests for identifying mutations in the NRAS and BRAF genes for physicians who prefer to order individual tests. The company launched its first laboratory test for detecting mutations in the KRAS gene in August 2008.

Quest Diagnostics is the leader in cancer diagnostics, including tests for colorectal cancer. In addition to its EGFR Pathway and related laboratory tests, the company's Enterix busines
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SOURCE Quest Diagnostics Incorporated
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