Navigation Links
Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service
Date:6/1/2009

em determine more reliably whether or not to provide therapy with EGFR antagonists to the individual patient," said Dr. Maher Albitar, M.D., medical director and chief of Research and Development, Hematology and Oncology, Quest Diagnostics.

Anti-EGFR therapies are designed to impede cellular proliferation caused by activation of EGFR, but can trigger several side effects, including fatigue, skin rash, and nausea and vomiting. Up to 40 percent of patients with mCRC in the U.S. have mutations in the KRAS gene that render anti-EGFR therapy ineffective. In January 2009, the American Society of Clinical Oncology (ASCO) produced a provisional clinical opinion (PCO) recommending that all patients with mCRC who are candidates for anti-EFGR therapy be tested for KRAS gene mutations (specifically in codons 12 and 13), and that anti-EFGR antibody therapy should not be administered if mutations are found.

However, fewer than 50 percent of patients with wild-type (normal) KRAS genes respond to anti-EGFR therapy, suggesting that additional mechanisms may affect response. Studies demonstrate that in patients with mCRC, about five percent may have mutations in the NRAS gene and eight percent may have mutations in the BRAF gene, and that mutations in these genes are associated with poor anti-EGFR treatment response. In February 2009, The New England Journal of Medicine published correspondence by Dr. Albitar and his colleagues at Quest Diagnostics regarding results of a study of 572 colon cancer samples that found that 11 percent of RAS mutations would have been missed if only codons 12 and 13 of the KRAS gene had been analyzed (as recommended by ASCO's PCO), and recommended RAS mutation testing include KRAS and NRAS encompassing codon 61 in addition to codons 12 and 13.

The Quest Diagnostics EGFR Pathway Test sequentially detects mutations along the EGFR Pathway, beginning with KRAS
'/>"/>

SOURCE Quest Diagnostics Incorporated
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
2. The 7 Key Questions About the Schwarzenegger/Nunez Health Care Compromise
3. LifeQuest Announces End of Immunity Health Challenge Contest
4. LifeQuest World Corporation Proud Contributor to Dietary Supplement Education Alliance (DSEA)
5. Quest Diagnostics to Speak at the Bear Stearns Healthcare Conference
6. Study Questions Dead-End Cancer Clinical Trials
7. 6 Years Later, 9/11 Health Questions Linger
8. U.S. Physicians Question Presidential Candidates
9. RFID Implant Cancer Questions Concern Patients
10. Study Questions Genetic Screening for Treatable Diseases
11. Mass. Judge Denies Request by Breastfeeding Mother for More Break Time on Medical Licensing Exam
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... 26, 2014 The report “Laboratory ... Mode (On-premise, Hosted, SaaS), End User Labs (Clinical, ... Component (Software, Services) - Global Forecast to 2019” ... restraints, challenges, opportunities, current market trends, and strategies ... and forecasts of the revenue and market growth. ...
(Date:11/26/2014)... November 26, 2014 The Maryland ... for the tenth annual MEDA Awards, which, sponsored ... excellence in Maryland. “The MEDA Awards recognize the ... to the state. We encourage our members to ... making a positive economic impact in the state ...
(Date:11/26/2014)... The family foundation of Best Buy founder, Richard ... Foundation (Meso Foundation), half of which will be specifically ... Program . The focus area of the Richard M. ... organizations that can generate transformational results in education, human ... and chairman emeritus of Best Buy Co., Inc., the ...
(Date:11/26/2014)... 2014 The Deptford Center for ... a partnership designed to improve the quality of ... failure (CHF) patients in the South Jersey area. ... Cardiology team will help CHF patients manage their ... partnership pairs the Cardiac Recovery program at the ...
(Date:11/26/2014)... Increasing demand for diagnostic imaging ... surgeries has paved way for consequent increase in ... various types of cancers and cardiac diseases globally ... for these owing to their use in diagnosing ... market can also be attributed to advancements in ...
Breaking Medicine News(10 mins):Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Maryland Economic Development Association Seeking Submissions for 2015 Awards 2Health News:Best Buy Founder’s Family Foundation Donates $100,000 to Organization Fighting Deadly Cancer 2Health News:Best Buy Founder’s Family Foundation Donates $100,000 to Organization Fighting Deadly Cancer 3Health News:Advanced Heart Failure Recovery Program comes to Deptford Center for Rehabilitation and Healthcare 2Health News:Advanced Heart Failure Recovery Program comes to Deptford Center for Rehabilitation and Healthcare 3Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3
... be formally assessed to determine whether they would benefit from ... AMA Vice President and paediatric psychiatrist, Dr Choong-Siew Yong, said ... specific early interventions before and soon after birth, and until ... a positive impact on a child’s mental and physical health,” ...
... enteritidis is a type of salmonella bacteria.It is usually found ... //reports that this bacteria is now found more often in ... show a fourfold increase of salmonella enteritidis on chicken meat., ... 40,000 people every year with an annual death toll of ...
... teen-age smoking finds there is no solid evidence about ... have started. // ,Because one-third of smokers take ... percent before age 21, most previous studies of youth ... ,“There is not yet sufficient evidence to test ...
... pigs has been identified by scientists in South Korea – ... //microbiology, following the findings of J.J. Shin and colleagues at ... pathogen, the H3N1 influenza A virus that can be found ... reassortment of influenza viruses. The virus, which was first identified ...
... and Brain Research Centre at Canada's University //of British ... genetic predisposition to Alzheimer’s disease. , ,During the ... captivity marked by low-oxygen levels for about 16 hours ... was subject to normal levels of oxygen. ...
... A century ago this month, German psychiatrist Alois ... //which ultimately came to bear his name. While ... develop treatments have progressed significantly in recent years, ... ,A new research tool developed by Susan Liebman, ...
Cached Medicine News:Health News:Early Intervention to Improve Kids’ Healt 2Health News:No Proven Programs to Help Teens Quit Smoking 2Health News:No Proven Programs to Help Teens Quit Smoking 3Health News:Yeast Model Shows Promise as Alzheimer's Test 2
(Date:11/26/2014)... and NEW YORK and ... As the leading distributor of market intelligence, MarketResearch.com is ... report by IQ4I Research and Consultancy focusing on the ... more about IQ4I Research visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . ... Pharmaceutical Ingredients Global Market – Forecast to 2020 ...
(Date:11/26/2014)... , Nov. 25, 2014  Medtronic,s ... has been widely discussed in the media ... also creating a stronger leading player in one ... Kalorama Information.  The healthcare market research firm said ... will feature a diverse set of solutions spanning ...
(Date:11/26/2014)... Nov. 25, 2014  Breckenridge Pharmaceutical, Inc. announced ... ANDA agreement with Pii (Pharmaceutics International, Inc.) ( ... Breckenridge and Pii expect to develop and commercialize ... agreement, Pii will develop, manufacture and supply the ... products under its own label.  The drugs, comprised ...
Breaking Medicine Technology:MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with Pharmaceutics International, Inc. 2
Compact instrument that quickly dries racks of slides using warm air....
Liquichek Blood Gas Plus EGL Control is an aqueous product used to monitor the measurement of pH, pCO2, pO2, electrolytes, glucose and lactate (lactic acid)....
Liquichek Cardiac Markers Control is a multi-analyte liquid control for monitoring cardiac assessment tests. Assayed values are available for major instruments....
Meter Trax Control is a whole blood quality control that can be used for glucose, hemoglobin and hematocrit testing on point of care instruments....
Medicine Products: