Navigation Links
Quality of life benefits of transcatheter aortic valve replacement differ by access site
Date:11/10/2011

SAN FRANCISCO, CA NOVEMBER 10, 2011 Results of the PARTNER Cohort A QOL study demonstrate that transcatheter aortic valve replacement (TAVR) results in improved quality of life compared with surgical valve replacement, but only when performed via the transfemoral approach. The results of the study were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Over the past decade, TAVR has been developed as a less invasive alternative to surgical valve replacement (AVR) for high-risk patients with severe aortic stenosis. In the landmark PARTNER trial, reported earlier this year at the ACC Scientific Sessions, TAVR was found to be non-inferior to surgical AVR for the primary endpoint of one-year mortality among high risk patients with severe aortic stenosis. However, the overall impact of this alternative treatment on the patients' health-related quality of life has not been previously reported.

Researchers measured quality of life using the Kansas City Cardiomyopathy Questionnaire (KCCQ, the primary endpoint), the SF-12 Health Status Survey, and the EuroQOL (EQ-5D). Patients were assessed on a broad range of factors, such as their symptoms, physical and social limitations and overall quality of life upon enrollment in the trial and at follow-up intervals of one month, six months and 12 months. A total of 699 patients were randomized to either TAVR (N=348) or SAVR (N=351).

The study population was then broken down between the patients who were eligible for transfemoral (TF) valve implantation (n=492) and a separate group of patients for whom only a transapical (TA) approach through a small incision in the chest was possible (n=207).

At one year follow-up, patients who underwent either surgical or transcatheter aortic valve replacement experienced substantial improvement in disease-specific and generic health quality of life measures. For TF patients, TAVR resulted in substantial quality of life benefits compared with surgical AVR at one month with similar benefits at later time points. For patients eligible only for the TA approach, there was no benefit of TAVR over AVR at any time point, and quality of life measures tended to be better with surgical AVR at both one and six months.

"Taken together with previous data, these findings demonstrate that for patients suitable for a transfemoral approach, transcatheter aortic valve replacement provides meaningful clinical benefits compared with surgical aortic valve replacement from the patient's perspective," said David J. Cohen, MD, the principal investigator for the quality of life sub-study. Dr. Cohen is Professor of Medicine at the University of Missouri-Kansas City and Director of Cardiovascular Research at Saint Luke's Mid America Heart Institute.

"The lack of benefit and suggestion of worse outcomes among patients ineligible for the transfemoral approach suggest that the transapical approach may not be preferable to surgical aortic valve replacement in such patients. Whether further experience and refinements in the transapical approach can overcome these limitations should be the subject of future investigation."


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Cancer survivorship research must look at quality of life
2. High-quality white light produced by four-color laser source
3. Quality-of-life for women an issue: in some matters of the heart, women do not fare as well as men
4. SMU scientists to lead water quality study at UN refugee camps
5. Researchers question key quality measure for asthma
6. Researchers transform iPhone into high-quality medical imaging device
7. Does race dictate quality of care?
8. ASGE recognizes 21 endoscopy units for quality and safety
9. Study finds hospitals of last resort deliver lower quality of lung cancer care
10. Federal investment in electronic health records likely to reap returns in quality of care
11. Clinic demonstrates improved quality of care resulting in cost savings for Medicare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Achieve ... Desert, is opening a new office in San Clemente, California this month. Achieve ... in Southern California, successfully treating individuals struggling with major depression. Depression impacts over ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... – will lecture to primary eye care practitioners on the latest breakthroughs in ... upcoming 13th Semi-Annual Continuing Education Symposium, according to eye surgeon, Jeffrey Martin, MD, ...
(Date:1/17/2017)... ... January 17, 2017 , ... Wettstein Agencies, a Denver ... business professionals throughout central Colorado, is joining local nonprofit Aurora Warms The Night ... The Night organization is committed to breaking the cycle of homelessness and poverty ...
(Date:1/17/2017)... ... January 17, 2017 , ... Physicians Education Review®, LCC (PER®) ... speaker for the 34th Annual Miami Breast Cancer Conference®, on March 9-12, 2017 ... Phil Talamo, said, “We are delighted to have Sandra Lee join us as ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, FloSports , a ... announced a new agreement as part of a long-term extension of their media partnership. ... the airing of some of the sport’s premier events exclusively on FloWrestling.com as well ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Research and Markets has announced the addition of ... to their offering. ... The global fluoropolymer market in the healthcare industry to grow ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has been ... experts. The report covers the market landscape and its growth prospects ...
(Date:1/17/2017)... Jan. 17, 2017 Following an initial ... praised the Food and Drug Administration,s (FDA,s) final ... Drug Products by Pharmacies and Outsourcing Facilities." In ... limitation on pre-packaging -- which would have put ... to long term care (LTC) pharmacies.  ...
(Date:1/17/2017)... ReportsnReports.com adds "Anaphylaxis - Pipeline Review, H2 2016" ... Anaphylaxis,s therapeutic pipeline with comprehensive information on the therapeutic development ... assessment by drug target, mechanism of action (MoA), route of ... featured news and press releases. ... Complete report on H2 2016 pipeline ...
Breaking Medicine Technology: