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Quality of life benefits of transcatheter aortic valve replacement differ by access site
Date:11/10/2011

SAN FRANCISCO, CA NOVEMBER 10, 2011 Results of the PARTNER Cohort A QOL study demonstrate that transcatheter aortic valve replacement (TAVR) results in improved quality of life compared with surgical valve replacement, but only when performed via the transfemoral approach. The results of the study were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Over the past decade, TAVR has been developed as a less invasive alternative to surgical valve replacement (AVR) for high-risk patients with severe aortic stenosis. In the landmark PARTNER trial, reported earlier this year at the ACC Scientific Sessions, TAVR was found to be non-inferior to surgical AVR for the primary endpoint of one-year mortality among high risk patients with severe aortic stenosis. However, the overall impact of this alternative treatment on the patients' health-related quality of life has not been previously reported.

Researchers measured quality of life using the Kansas City Cardiomyopathy Questionnaire (KCCQ, the primary endpoint), the SF-12 Health Status Survey, and the EuroQOL (EQ-5D). Patients were assessed on a broad range of factors, such as their symptoms, physical and social limitations and overall quality of life upon enrollment in the trial and at follow-up intervals of one month, six months and 12 months. A total of 699 patients were randomized to either TAVR (N=348) or SAVR (N=351).

The study population was then broken down between the patients who were eligible for transfemoral (TF) valve implantation (n=492) and a separate group of patients for whom only a transapical (TA) approach through a small incision in the chest was possible (n=207).

At one year follow-up, patients who underwent either surgical or transcatheter aortic valve replacement experienced substantial improvement in disease-specific and generic health quality of life
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Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

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