Navigation Links
Quality control mechanism tags defective sperm cells inside the body
Date:1/23/2008

COLUMBIA, Mo. Defective sperm cells do not pass through the body unnoticed. A new University of Missouri study provides evidence that the body recognizes and tags defective sperm cells while they undergo maturation in the epididymis, a sperm storage gland attached to the testis. According to researchers, only the best sperm that have the highest chance of succeeding in fertilization will survive the production process without a tag.

A small protein called ubiquitin marks abnormal sperm cells, including cells that have two heads, two tails or are otherwise misshaped. This recycling tag on the sperm cell tells the body which cells need to be broken back down into amino acids. This provides evidence that there is an active removal process or marking of defective sperm during the epididymal passage.

Fertilization is, in a way, a numbers game, said Peter Sutovsky, associate professor of animal sciences, clinical obstetrics and gynecology in the MU College of Agriculture, Food and Natural Resources. You need a certain number of normal sperm cells to reach the egg. If too many are tagged with ubiquitin, there may be not enough to fertilize an egg.

This study suggests that the male reproductive system must be able to evaluate and control the quality of the sperm to insure an optimal chance of fertilization. High levels of ubiquitin in the sperm can indicate low-sperm count or infertility. This process of quality control has been found in both humans and other mammals including bulls, boars and rats.

In many cases, the cells that are tagged with ubiquitin are obviously abnormal with two tails or two heads, but many of them look like they dont have defects, Sutovsky said. Oftentimes, these cells may look normal but lack proteins that are important to fertility.

Once sperm cells are tagged as defective, it is unlikely that the process can be reversed. Sutovsky stresses the importance of a healthy lifestyle to reduce the likelihood of abnormal sperm cells. He suggests avoiding exposure to toxic chemicals, abstaining from smoking and maintaining a healthy diet. He suggests people who work with toxins on a daily basis should minimize their exposure by wearing protective clothing and respirators.


'/>"/>

Contact: Jennifer Faddis
FaddisJ@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Governor Rendell Offers Coverage to 29,000 on AdultBasic Waiting List; Unveils New Policy to Improve Quality of Care for the Low-Income and Pennsylvanians With Disabilities
2. National Business Coalition on Health Awards Grants to 14 Coalitions for Diabetes Quality Programs
3. States Patient Safety Report a Valuable Tool For Hospitals Quality Improvement Work
4. Virginia Cares Uninsured Program (VCUP) Announces Early Successes in Helping Uninsured Virginians Access Quality Healthcare
5. Anyone can save a life: Penn researchers lead national efforts to improve CPR quality
6. Heavy metal slips down UK air quality charts
7. Integrating Quality into Business Systems for High Performance, Complimentary Excerpt Available from Best Practices, LLC
8. Michigan Quality Council (MQC) Names Oakwood Healthcare Inc. 2007 State Quality Award Recipient
9. Tonsillectomy significantly improves quality of life in adult and pediatric patients
10. Michigan Quality Council (MQC) Names Henry Ford Health System 2007 State Quality Award Recipient
11. New Web Site Opens Window on Charges, Payments, Quality of Care at Michigan Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... 03, 2016 , ... Boston Children’s Hospital today announced its new pediatric Simulation ... tricky or rare procedures in an environment that looks and feels real. , Located ... to inventors and “hackers” to develop and test new devices or software platforms and ...
(Date:5/3/2016)... ... ... Each year, about 800,000 people suffer from cerebral vascular accidents, or strokes. ... for one death every four minutes. Many people who survive a stroke are ... a video series called “Your Brain,” in conjunction with its medical journal “Balance,” in ...
(Date:5/3/2016)... ... 2016 , ... Ogawa World USA introduced the first of its kind ... Smart Application. The Smart 3D combines the best in technological advancement, design, and massage ... and specialized massage program, each user has a tailored experience unparalleled by any other ...
(Date:5/3/2016)... New York, NY (PRWEB) , ... May 03, ... ... coordination solutions for the healthcare industry, announced today that Legacy Health is expanding ... Intrigma’s Efficient Works platform), after a highly successful initial proof of concept. The ...
(Date:5/3/2016)... ... May 03, 2016 , ... Octo ... solutions and digital consulting services to the federal government, has been awarded a ... / Indefinite Quantity (ID/IQ) contract in support of the U.S. Army Program Executive ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... BURLINGAME, Calif. , April 28, 2016 /PRNewswire/ ... first-ever widely accessible breast and ovarian cancer risk ... cancer panel analyzing 30 genes that highly impact ... and women. Available today, the Color Test analyzes ... pancreatic, prostate, stomach, and uterine cancers. The Color ...
(Date:4/28/2016)... April 28, 2016  The blood testing market in ... according to Kalorama Information and The Freedonia Group in ... nucleic acid testing.  The healthcare research firm said that ... developing blood collection stations and in improving testing at ... Information,s report, Blood Testing Market in China ...
(Date:4/28/2016)... , Net Sales of $1.90 billion represent an increase of ... and an increase of 1.2% on an adjusted pro forma, ... quarter were $0.52 reported, a decrease of 47.5% from the ... over the prior year period , The Company increases ... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today ...
Breaking Medicine Technology: