Navigation Links
Qrono Awarded Contract to Enhance the Immunogenicity of Dengue Vaccine
Date:11/9/2015

Qrono Inc. today announced that the US Army SBIR Program awarded Qrono a $150,000 Small Business Innovation Research (SBIR) Phase I contract to develop and test a novel adjuvant to enhance the immunogenicity of dengue vaccine.

Dengue fever incidence has grown exponentially over the past 50 years and now causes disease in nearly 100 million people annually. It is currently ranked 2nd in the Infectious Disease Threats to the U.S. Military Prioritization Panel (DoD Memo: 23 April 2010). There are currently no licensed vaccines to prevent dengue, nor drugs to treat dengue illness. Vaccination offers the most effective method of protecting at-risk individuals. The long immunization schedule (12 months) and partial protection (30­60%) of the latest trial vaccines set clear milestones for improvement. International travelers and Warfighters being deployed to tropical or subtropical regions require more immediate and more complete immunity.

To this end, Qrono will computationally optimize and develop a transformational microparticle adjuvant platform called M2 that will generate rapid onset immunity in a new dengue vaccine through molecularly engineered control over antigen uptake and T cell stimulation. The ultimate goal for this new vaccine is to rapidly protect against dengue’s manifestations with a single dose and to create an effective dengue vaccine for protecting military personnel against this potentially mission-aborting disease. Qrono’s computational drug delivery technology called QronoMetrics™ allows Qrono to rapidly create the formulations that will optimize M2’s adjuvant effect.

“This effort takes the initial steps toward developing the world’s first vaccine capable of rapidly generating complete, lasting protection from dengue fever and will establish a new state-of-the-art in adjuvant design by using computational methods,” said Qrono CEO Larry Zana. “This vaccine promises not only to reduce the global economic impact of dengue but also to considerably reduce the worldwide human suffering and death it causes. Success of this new vaccine will establish M2 as a key adjuvant platform for use in vaccines for other pathogens such as influenza or Ebola.”

The contract will enable Qrono to further demonstrate the utility of QronoMetrics™ in developing microparticle formulations in an unprecedented, rapid period of time for a wide range of target pharmaceuticals. In Phase I, Qrono will develop and demonstrate proof-of-concept of the M2 platform with computationally optimized formulations. Upon successful completion of Phase I, Qrono will be eligible to apply for Phase II funding that will continue vaccine development through preclinical efficacy studies in mouse and monkey models before beginning the clinical trials needed for regulatory approval and commercialization.

This contract was funded by the Army SBIR Program. The work is managed by the US Army Medical Research and Materiel Command under Contract No. W81XWH-15-C-0120 and will be managed and done in collaboration with the Viral and Rickettsial Diseases Department at the Naval Medical Research Center. The views, opinions and/or findings contained in this report are those of the author and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. In conducting research using animals, the investigator will adhere to the Animal Welfare Act Regulations and other Federal statutes relating to animals and experiments involving animals and the principles set forth in the current version of the Guide for Care and Use of Laboratory Animals, National Research Council.

# # #

About Qrono:
Qrono reformulates FDA approved drugs and creates new, long-acting injectable (LAI) medications with improved clinical and economic benefits. Our product pipeline focuses on therapeutic areas where LAIs offer high therapeutic and economic value, such as addressing high non-adherence or solving specific drug delivery challenges. Using our computational drug delivery technology, we can design LAIs much faster than legacy practice and with reduced regulatory and technical risk.

Read the full story at http://www.prweb.com/releases/qrono-computational/dengue-vaccine/prweb13066730.htm.


'/>"/>
Source: PRWeb
Copyright©2015 Vocus, Inc.
All rights reserved


Related medicine news :

1. Qrono Selected to Participate in the Buzz of BIO at the 2015 BIO International Convention
2. DRE Medical Awarded Refurbished Capital Equipment Agreement with Premier, Inc.
3. Georgia Partnership for Telehealth Awarded the HRSA Rural Child Poverty Telehealth Network Grant
4. BrightStar Care® of Cumming-Gainesville Awarded Accreditation from the Joint Commission
5. Sir Grout of Chicago, Local Tile and Grout Restoration Provider, Recently Awarded TrustDale Certification by Investigative Reporter Dale Cardwell
6. $260,000 Awarded to Augment Clinical Trial Program Funding
7. Sir Grout of Greater Boston, Local Tile and Grout Restoration Provider, Recently Awarded TrustDale Certification by Investigative Reporter Dale Cardwell
8. Gensuite® Audit AssistantTM Awarded 2015 OH&S New Product of the Year for EHS Software
9. Leena Gauba, Director of Imperial Healthcare Awarded Woman Leadership Award in Healthcare
10. Sir Grout of Atlanta, Local Tile and Grout Restoration Provider, Recently Awarded TrustDale Certification by Investigative Reporter Dale Cardwell
11. American Care Partners, a Skilled Home Health Care Provider for Children and Adults, awarded Joint Commision Home Health Care Accreditation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2019)... ... January 14, 2019 , ... Modere (the “Company”), a healthy, ... presence worldwide, today announced that it built on 2017’s growth momentum, delivering impressive ... double-digits in North America, by more than five times in Europe and by ...
(Date:1/14/2019)... (PRWEB) , ... January 15, 2019 , ... ... The Center for Inflammatory Bowel and Colorectal Diseases, Institute for Digestive Health ... invasive, outpatient procedure for treating hemorrhoids., A specially designed instrument known as a ...
(Date:1/14/2019)... (PRWEB) , ... January 14, 2019 , ... Trees can ... several reasons homeowners should have trees pruned, and winter is a great time to ... weight deadwood branches can lead to serious damage, especially during windy or icy storms. ...
(Date:1/14/2019)... ... January 14, 2019 , ... Dr. Kaveh Kanani D.D.S . is the head of ... This well established general dentist has recently unveiled an inventive method of inserting ... When a tooth is missing for an extended period of time, the jawbone that used ...
(Date:1/13/2019)... ... January 12, 2019 , ... ... celebrating its 35th year of service to the community, providing a variety of ... celebrating our 35th anniversary,” said New Vitae co-founder and owner Adam Devlin. ...
Breaking Medicine News(10 mins):
(Date:1/21/2019)... ... January 21, 2019 , ... ... teeth can also increase health risk factors, says a March 7, 2013 Web ... from an international study spanning just under 40 countries showed links between the ...
(Date:1/20/2019)... ... 2019 , ... California firefighter Trent Knuckles is the latest recipient of California ... of three prize packages that included a check for $2,250 to purchase the Liberty ... included a carry bag, backpack, RAID Glasses, flashlight, hats and more. The value of ...
(Date:1/15/2019)... (PRWEB) , ... January 15, ... ... leading provider of background screening, compliance and credentialing solutions, announces it was ... and risk management solutions. Cisive caters to the complex challenges and program ...
Breaking Medicine Technology: