Navigation Links
QBI neuroscientists make Alzheimer's disease advance
Date:6/10/2008

Queensland Brain Institute (QBI) neuroscientists at UQ have discovered a new way to reduce neuronal loss in the brain of a person with Alzheimer's disease.

Memory loss in people with Alzheimer's disease can be attributed to several factors.

These include a build-up of the neuro-toxin Amyloid beta the major component of amyloid plaques found in patients with Alzheimer's and corresponding degeneration of a specific population of nerve cells in the basal forebrain.

QBI neuroscientist Dr Elizabeth Coulson's research was recently published in the Journal of Neuroscience.

She said the research had established that the molecule known as p75 neurotrophin receptor was necessary for the Amyloid beta to cause nerve cell degeneration in the basal forebrain.

During her research, Dr Coulson's team found both in cultured cells and in an animal model of Alzheimer's disease that it was possible to completely prevent Amyloid beta toxicity by removing the p75 cell death receptor.

"Discovering how Amyloid beta triggers neuronal degeneration has been a question bugging neuroscientists for decades, and we have identified an important piece of the puzzle," Dr Coulson said.

These results provide a novel mechanism to explain the early and characteristic loss of brain cells that occurs in Alzheimer's disease which are known to be important for memory formation.

Dr Coulson already has patented molecules that can block p75 and is ready to begin testing them in animal models of Alzheimer's disease.

"If such therapy is successful, it probably wouldn't cure this multifaceted disease," Dr Coulson said.

"But it would be a significant improvement on what is currently available for Alzheimer's disease patients."

The World Health Organisation predicts that by 2040, neurodegenerative conditions will become the world's leading cause of death, overtaking cancer.

Alzheimer's disease is the most common dementia affecting 10 per cent of people over 65 and 40 per cent over 80 years of age.

Significant advances in determining the molecular regulation of nerve cell function and survival have major impact on our understanding of more complex areas such as behaviour, cognition, aging and neurological diseases.


'/>"/>

Contact: Dr. Elizabeth Coulson
communications@uq.edu.au
61-733-466-392
Research Australia
Source:Eurekalert

Related medicine news :

1. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
2. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
3. Alzheimers Research Target May Be a Dead End
4. Smoking may strongly increase long-term risk of eye disease
5. Pot bellies linked to early signs of cardiovascular disease
6. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
7. Radiologists encouraged to look beyond cancer for clinically unseen diseases
8. Use of certain lipid measures not more effective in predicting coronary heart disease
9. Role seen for cannabis in helping to alleviate allergic skin disease
10. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
11. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... Linda, CA (PRWEB) , ... ... ... an approach to healthcare that considers individuals’ genetic characteristics and the physical ... and precision therapy work in sync. In personalized medicine, diagnosing an individual’s ...
(Date:5/31/2016)... ... May 31, 2016 , ... St. Joseph Medical ... health information exchange, which enables physicians at SJMC’s two hospital campuses, downtown and ... participating organizations in the exchange. SJMC’s membership in the health information exchange underscores ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... back to particular advertising campaigns, to monitor the performance of sales and support ... maximize conversions and revenue. The software allows customers to record, transcribe, route, document, ...
(Date:5/31/2016)... ... May 31, 2016 , ... The Global Wellness Summit (GWS), ... on the future of wellness, travel, spa and beauty in Europe. The organization asked ... companies to leading economists and researchers - to forecast where wellness is headed in ...
(Date:5/31/2016)... ... ... Interest is on the rise for using the CRISPR-Cas9 system for functional ... hit validation. A key reason may be that high-throughput synthesis—combined with a proprietary algorithm ... collections in arrayed formats. , Arrayed crRNA screens have the advantage ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... Israel , May 31, 2016 CollPlant ... proprietary plant-based rhCollagen technology for tissue repair products - ... Scientist of Israel,s Ministry of ... million development project for 2016. The Chief Scientist,s grant amount ... authorized grant, which totaled NIS 4.7 million.  ...
(Date:5/31/2016)... PUNE, India , May 31, 2016 ... 2016" market research report with comparative analysis of Asthma ... mechanism of action (MoA), route of administration (RoA) and ... and press releases. It also reviews key players involved ... on late-stage and discontinued projects. Complete report ...
(Date:5/30/2016)... 30, 2016 According to ... Services Market by Type (Stability, Raw Materials, Method ... User (Pharmaceutical Companies, Medical Device Companies) - Global ... witnessed healthy growth during the last decade and ... 11.3% between 2016 and 2021 to reach USD ...
Breaking Medicine Technology: