Navigation Links
Putting the brakes on pain
Date:8/5/2013

Neuropathic pain pain that results from a malfunction in the nervous system is a daily reality for millions of Americans. Unlike normal pain, it doesn't go away after the stimulus that provoked it ends, and it also behaves in a variety of other unusual and disturbing ways. Someone suffering from neuropathic pain might experience intense discomfort from a light touch, for example, or feel as though he or she were freezing in response to a slight change in temperature.

A major part of the answer to the problem of neuropathic pain, scientists believe, is found in spinal nerve cells that release a signaling chemical known as GABA. These GABA neurons act as a sort of brake on pain impulses; it's thought that when they die or are disabled the pain system goes out of control. If GABA neurons could be kept alive and healthy after peripheral nerve or tissue injury, it's possible that neuropathic pain could be averted.

Now, University of Texas Medical Branch at Galveston researchers have found a way to, at least partially, accomplish this objective. The key, they determined, is stemming the biochemical assault by reactive oxygen species that are generated in the wake of nerve injury.

"GABA neurons are particularly susceptible to oxidative stress, and we hypothesized that reactive oxygen species contribute to neuropathic sensitization by promoting the loss of GABA neurons as well as hindering GABA functions," said UTMB professor Jin Mo Chung, senior author of a paper on the research now online in the journal Pain.

To test this hypothesis and determine whether GABA neurons could be saved the researchers conducted a series of experiments in mice that had been surgically altered to simulate the conditions of neuropathic pain. In one key experiment, mice treated with an antioxidant compound for a week after surgery were compared with untreated mice. The antioxidant mice showed less pain-associated behavior and were found to have
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. San Diego-based Nuspine Gains National Appeal and Rave Reviews, Putting a New Twist on Relieving Back Pain with its All-Natural Revolutionary Training Program
2. Austerity cuts to Spanish healthcare system are putting lives at risk
3. Enter the 2013 Putting Our Heads Together Migraine and Headache Poetry Contest Sponsored by Help for Headaches and Migraine Now
4. Putting it All on the Line to Create Jobs for Youth
5. Putting malaria on the SHELPH
6. Putting the Dietary Guidelines for Americans into Action: Behavior-Directed messages to Motivate Parents Published in the Journal of the Academy of Nutrition and Dietetics
7. Putting our heads together: Canines may hold clues to human skull development
8. Putting the squeeze on cells
9. Putting electronic cigarettes to the test
10. Putting Your Mental Health in Order
11. Study Recommends Putting Your Left Face Forward
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... 24, 2014 (HealthDay News) -- October,s shorter, darker days ... affective disorder, according to an expert. People ... feel overly tired, lack motivation and even have trouble ... lead to suicide, said Dr. Angelos Halaris, a professor ... Loyola University Chicago Stitch School of Medicine. "Seasonal ...
(Date:10/22/2014)... Medical Solutions , the ... to announce that our co-founder and CFO, Scott ... Staffing 100 for 2014. Anderson was also named ... people in the staffing industry,” in 2013.     , ... healthcare staffing company in the U.S., was named ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- The ... passengers arriving from Ebola-affected nations of West Africa ... screen them for infection with the virus. ... Jeh Johnson noted that 94 percent of air ... land at one of these five airports -- ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a world ... face, it certainly can be difficult to choose the right ... favor by doing it the healthy way? Set aside the ... your body, exercise regularly, and choose foods with the most ... you need to exercise more and eat less. Despite the ...
Breaking Medicine News(10 mins):Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2
... new diagnostic technique capable of producing three-dimensional, in-depth ... number of women who are recalled for additional ... clinical trial being conducted at Emory University Breast ... annual meeting of the Radiological Society of North ...
... Procedures through the Belly Button: Scar-Free ... ... Nov. 28 Cleveland Clinic urologists recently,performed a series of ... repair), ileal ureter replacement, and psoas hitch uretero-,neocystostomy (for ureteral ...
... Medical Entrepreneurs is Only a Phone Call or ... care entrepreneurs,working outside the traditional health insurance payment ... computer software to make,medical care more accessible and ... the National Center for Policy Analysis (NCPA)., http://www.ncpa.org/pub/st/st305/st305.pdf ...
... Be Presented at 9:00 a.m. ... ... The Trade, Health and Environment,Impact Project, a collaboration of community organizations ... East Yard Communities for Environmental Justice, Center for,Community Action & Environmental ...
... and clinical ... development experience to Celator., PRINCETON, N.J., ... develop combination chemotherapies to,treat different types of cancer, today ... R. Appelbaum, M.D., head of the,University of Washington School ...
... that had the neurological disease, researchers say , WEDNESDAY, ... to a possible treatment for amyotrophic lateral sclerosis (ALS), ... a protein normally found in human cells into mice ... The team found that the treatment delayed symptoms and ...
Cached Medicine News:Health News:'Stereo' mammography takes breast imaging to a new dimension 2Health News:World Firsts by Cleveland Clinic Urologists 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 3Health News:Los Angeles Port Pollution, Int'l Trade & Goods Movement Conference This Weekend 2Health News:Frederick R. Appelbaum, M.D. and Ross C. Donehower, M.D. Join Scientific Advisory Board of Celator(R) Pharmaceuticals 2Health News:Cell Protein Might Help Treat ALS 2
(Date:10/25/2014)... 2014 Advanced Photonix ® (NYSE MKT: API) ... financial results on Monday, November 10, 2014. A press release ... of the market and the Company will host a live ... EDT on the same day. Participating in the ... Rob Risser (COO and Director), and Jeff ...
(Date:10/25/2014)... Oct. 24, 2014  In 2008, two of Dr. ... of multiple controlled substances, on a regular basis, that ... that Dr. Gurney was practicing "all the time" while ... of his employees said that Dr. Gurney was prone ... patients." Dr. Gurney,s behavior became increasingly erratic ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
Breaking Medicine Technology:Advanced Photonix to Webcast Fiscal 2015 Second Quarter Earnings 2Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 2Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 3Strong Participation in Best Practices' Medical Affairs Consortium Survey 2
... July 5, 2011 Amgen (NASDAQ: AMGN ) ... collaborating with the National Aeronautics and Space Administration (NASA) Ames ... antibody in an experiment that will take place aboard space ... Flight STS-135, scheduled to launch July 8, 2011. ...
... NEW YORK, July 5, 2011 ORBIS and its ... intensive three-week program in Ulaanbaatar, Mongolia (June 19 - ... – a state-of-the-art hospital with wings. The mission was ... care, and included a three-week ophthalmic skills exchange and ...
Cached Medicine Technology:Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss 2Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss 3Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss 4Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss 5Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss 6ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 2ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 3ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: