Navigation Links
Putting a brake on tumor spread

A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream.

The findings are published in this week's online issue of the Journal of Cell Biology.

Blood vessels are tightly lined with endothelial cells, which form a permeability barrier to circulating cells and molecules. "Our studies show that pharmacological or genetic inhibition of the endothelial protein focal adhesion kinase, or FAK, prevents tumor spread by enhancing the vessel barrier function."

The researchers found that selective FAK inhibition within endothelial cells prevented spontaneous tumor metastasis without alterations in tumor size. Schlaepfer, with colleagues at the UC San Diego Moores Cancer Center, is exploring whether inhibiting targets like FAK, which has important regulatory functions in both tumor cells and blood vessels, might provide a dual mechanism for preventing both cancer growth and spread.

Using mouse models of breast, ovarian and melanoma tumors, first author Christine Jean, PhD, showed that FAK activity was elevated in the blood vessels surrounding tumors, compared to normal tissue. FAK modifies the function of other cellular proteins, and researchers identified a previously unknown FAK target: a protein called vascular endothelial cadherin (VE-cadherin) that helps endothelial cells fasten tightly together. When modified by FAK, VE-cadherin complexes fall apart and blood vessels become leaky. Inactivating FAK within endothelial cells prevented this unwanted permeability and helped block the ability of tumor cells to pass through endothelial cell barriers.

Schlaepfer said the research has major clinical implications: Metastasis or the spread of a cancer from its originating site to other parts of the body is responsible for 90 percent of cancer-related deaths. "This fact alone underscores the need for a better mechanistic understanding of the metastatic process," Schlaepfer said. He noted that several FAK-inhibitors are currently being tested in clinical trials.


Contact: Scott LaFee
University of California - San Diego

Related medicine news :

1. Putting a Whole New Spin on Spine Care Service
2. Putting Lupus in permanent remission
3. Putting sleep disorders to bed
4. Golf Putting Tips
5. How “Breakthrough Putting Secrets” Helps People Become Professional Golfers – Vinamy
6. Putting Tips
7. How “Breakthrough Putting Secrets” Helps People Play Golf Professionally –V-kool
8. Putting the brakes on pain
9. San Diego-based Nuspine Gains National Appeal and Rave Reviews, Putting a New Twist on Relieving Back Pain with its All-Natural Revolutionary Training Program
10. Austerity cuts to Spanish healthcare system are putting lives at risk
11. Enter the 2013 Putting Our Heads Together Migraine and Headache Poetry Contest Sponsored by Help for Headaches and Migraine Now
Post Your Comments:
Related Image:
Putting a brake on tumor spread
(Date:12/1/2015)... ... 2015 , ... The Multiple System Atrophy Coalition has announced the launch of ... (MSA) research, timed today to coincide with Giving Tuesday 2015, a global day of ... to work and be productive, to do simple daily activities like walking to the ...
(Date:12/1/2015)... ... ... Royal River Natural Foods — a locally-owned, independent natural health store in ... nutritional supplement creatine, along with resistance training for a year, had more new bone ... report is part of the December 2015 issue of Natural Insights for Well Being®, ...
(Date:12/1/2015)... ... December 01, 2015 , ... Baptist Medical Center ... and is the only hospital in the region providing what is known as ... transcatheter pacing patients were revealed recently at a medical conference and published in ...
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015 -- InstantLabs ... company’s growing product line of food safety and seafood fraud prevention tools. , ... – allow InstantLabs to offer fast, reliable species identification for the four most ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic foot wounds ... Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a health care ... to diseases of the diabetic foot. The American Board of Multiple Specialties ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 01, 2015 ... the "Medium Molecular Weight Polyisobutylene Market ... Other Applications - Global Industry Analysis, Size, ... 2023" report to their offering. ... addition of the "Medium Molecular Weight ...
(Date:12/1/2015)... CLEVELAND , Dec. 1, 2015   ... innovation firm, today announced the publication of a ... Entering the Direct-to-Consumer Medical Market". The whitepaper gives ... roadmap for successfully penetrating this lucrative segment. ... purchase healthcare products to manage their own health, ...
(Date:12/1/2015)... 1, 2015 Array BioPharma Inc. ... its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public ... through a webcast on the Array BioPharma ... --> , ...
Breaking Medicine Technology: