Navigation Links
Putrescine water may be Fountain of Youth for eggs
Date:11/26/2012

This press release is available in French.

Ottawa An Ottawa scientist has discovered a critical reason why women experience fertility problems as they get older. The breakthrough by Dr. John Liu, a senior scientist at the Ottawa Hospital Research Institute and professor at the University of Ottawa, also points to a simple solution that could increase the viability of egg cells for women in their late 30s and older putrescine water.

In an online editorial published by Aging based on his recently published findings, Liu outlines how a simple program of drinking water or taking a pill that contains the naturally occurring compound putrescine could reduce the rate at which middle-aged women produce eggs with the incorrect number of chromosomes, the leading cause of reduced fertility and increases in miscarriages and congenital birth defects.

Putrescine is naturally produced in mammals by an enzyme called ornithine decarboxylase,or ODC, and is easily absorbed and cleared by the body. In female mammals, ODC levels are known to rise during ovulation, when the egg cell matures and is released from the ovary. Dr. Liu has shown that ODC levels rise very little in older females. He has also shown that inhibiting ODC levels in young mice leads to an increase in egg cells with chromosomal defects.

Taking this a step further, Dr. Liu's team gave older mice putrescine water in the period immediately leading up to and during ovulation, and found that it reduced the incidence of defective eggs by more than 50%.

This is a remarkable outcome for such a simple approach," says Dr. Liu. "However, we could not have imagined this without first understanding the role that ODC and putrescine play in maintaining the chromosomal integrity of egg cells. While there is work to be done before it can be approved for clinical use, we feel this approach could be used for natural conception as well as in vitro fertilization."

Although promising, a putrescine pill is still a long way from being available on the market. Putrescine is toxic to the fetus if it is administered after conception, which makes timing, dosage and monitoring critical. Accordingly, this approach must go through the appropriate stages of testing to determine its clinical safety and effectiveness in humans.


'/>"/>

Contact: Paddy Moore
padmoore@ohri.ca
613-737-8899 x73687
Ottawa Hospital Research Institute
Source:Eurekalert

Related medicine news :

1. Super storm tracked by European Space Agency water mission
2. Water Workouts a Great Alternative: Study
3. Students win $100K for 3-D printer to turn waste plastic into composting toilets, rainwater systems
4. A TECNALIA study reveals the loss of nanomaterials in surface treatments caused by water
5. Water quality study shows need for testing at state migrant camps
6. New analysis of drinking water-related gastrointestinal illness
7. Water or Sports Drink?
8. Water pipe smoking has the same respiratory effects as smoking cigarettes
9. Tap Water Used in Neti Pots Tied to Rare, Fatal Brain Infection
10. Tap Water Used in Neti Pot Tied to Rare, Fatal Brain Infection
11. Tap Water Use in Neti Pot Tied to Rare, Fatal Brain Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & ... (TGIG), has initiated cultivation and processing operations at its production facility, and opened ... , Puradigm is the manufacturer of a complete system of proactive air and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
Breaking Medicine Technology: