Navigation Links
Pushing the boundaries of stem cells
Date:5/7/2014

(NEW YORK May 7) Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation.

The study, published in the May issue of The Journal of Clinical Investigation, looked at ways to expand the number of hematopoietic stem cells (HSC) in the laboratory required to replenish and renew blood cells. Cord blood stem cells have the ability to rapidly divide in the presence of combinations of growth factors but they often lose their marrow-repopulating potential following cell division. Researchers looked at ways to overcome this limitation by inducing a genetic program by which a stem cell retains its full functional properties after dividing in the laboratory.

"Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a single collection," said Pratima Chaurasia, PhD, Assistant Professor of Medicine at the Tisch Cancer Institute at Mount Sinai. "These limitations have resulted in a high rate of graft failure and delayed engraftment in adult patients."

Researchers used a technique called epigenetic reprogramming which reshaped cell DNA by treating cells with a combination of histone deacetylase inhibitors (HDACI) and valproic acid. The VPA-treated cells produced a greater number of repopulating cells, and established multilineage hematopoiesis in primary, secondary and tertiary immune-deficient mice.

"We're excited by these results. The findings have important implications for patients battling blood cancers and the difference between success and failure of life saving stem cell transplants." added Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Director of Myeloproliferative Disorders Research Program at the Tisch Cancer Institute at Mount Sinai.


'/>"/>

Contact: Lucia Lee
NewsMedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Health Reform 2.0: Governors Pushing Back on Medicaid Expansion
2. Pushing Competition Aside, Tabitha and The Landing Collaborate to Benefit Nebraska Elders
3. Limited Healthcare Benefits Pushing Seniors and Retirees to Medical Travel Alternatives
4. Judge Orders Postponement of First Bellwether Trial in DePuy Orthopaedics Inc.’s Multidistrict Litigation, Pushing It to Sept. 24, Parker Waichman LLP Reports
5. The FDA is Pushing For Greater Restrictions on Prescription Painkillers: Now what?
6. Virtual boundaries: How environmental cues affect motivation and task-oriented behavior
7. A new European network crosses the boundaries for excellence in language and perception research
8. New drug prevents spread of human prostate cancer cells
9. Tiny hitchhikers attack cancer cells
10. To prevent leukemias dreaded return, go for the stem cells
11. Scientists identify major source of cells defense against oxidative stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... PrideStaff, ... Vice President of Franchise Development, Paula Turner Pizarro, was recently featured on Fox ... features the insights of top business leaders from across the globe, provides viewers ...
(Date:1/18/2017)... ... January 18, 2017 , ... Park Agencies Insurance ... services to families and business owners in the greater Kansas City area, is ... developmental disabilities. , The Lakemary Center is a comprehensive educational resource center that ...
(Date:1/18/2017)... Alexandria, VA (PRWEB) , ... January 18, 2017 , ... ... services in family, cosmetic and implants dentistry. His modern dental practice has two convenient ... Qureshi as a 2017 Top Rated Dentist for the Alexandria area. This ...
(Date:1/18/2017)... ... 18, 2017 , ... Michael J. Hennessy Associates, Inc., (MJH), ... for Biosimilars, announced Michael J. Hennessy Associates, Inc. President Michael J. Hennessy, Jr. ... through thought leader interaction in, live video and interactive digital platforms. , In ...
(Date:1/18/2017)... Lebanon, NH (PRWEB) , ... January 18, 2017 ... ... the launch of the revolutionary Active Brake Technology (ABT), an innovative braking system ... stability. , Active Brake Technology addresses one of the biggest concerns of beginner ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017   Synthetic Biologics, Inc. (NYSE ... designed to preserve the microbiome to protect and ... to initiate a Phase 2b/3 adaptive pivotal trial ... lactone designed to reduce methane production by certain ... to treat the underlying cause of irritable bowel ...
(Date:1/18/2017)...  Aprima Medical Software, a leading provider of ... and revenue cycle management (RCM) solutions for medical ... reseller Healthcare Data Solutions (HDS) of Coral Cables, ... assume full support for HDS,s customers, which include ... 15 states. Financial terms were not disclosed. ...
(Date:1/18/2017)... Jan. 18, 2017   Spotlight Innovation Inc. ... Therapeutics plans, in the second quarter of 2017, ... roll-on intended to provide relief from chronic pain, ... analgesics. It was developed under a licensing agreement ... products derived from snake venom. Additionally, Caretta Therapeutics ...
Breaking Medicine Technology: