Navigation Links
Pushing the boundaries of stem cells
Date:5/7/2014

(NEW YORK May 7) Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation.

The study, published in the May issue of The Journal of Clinical Investigation, looked at ways to expand the number of hematopoietic stem cells (HSC) in the laboratory required to replenish and renew blood cells. Cord blood stem cells have the ability to rapidly divide in the presence of combinations of growth factors but they often lose their marrow-repopulating potential following cell division. Researchers looked at ways to overcome this limitation by inducing a genetic program by which a stem cell retains its full functional properties after dividing in the laboratory.

"Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a single collection," said Pratima Chaurasia, PhD, Assistant Professor of Medicine at the Tisch Cancer Institute at Mount Sinai. "These limitations have resulted in a high rate of graft failure and delayed engraftment in adult patients."

Researchers used a technique called epigenetic reprogramming which reshaped cell DNA by treating cells with a combination of histone deacetylase inhibitors (HDACI) and valproic acid. The VPA-treated cells produced a greater number of repopulating cells, and established multilineage hematopoiesis in primary, secondary and tertiary immune-deficient mice.

"We're excited by these results. The findings have important implications for patients battling blood cancers and the difference between success and failure of life saving stem cell transplants." added Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Director of Myeloproliferative Disorders Research Program at the Tisch Cancer Institute at Mount Sinai.


'/>"/>

Contact: Lucia Lee
NewsMedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Health Reform 2.0: Governors Pushing Back on Medicaid Expansion
2. Pushing Competition Aside, Tabitha and The Landing Collaborate to Benefit Nebraska Elders
3. Limited Healthcare Benefits Pushing Seniors and Retirees to Medical Travel Alternatives
4. Judge Orders Postponement of First Bellwether Trial in DePuy Orthopaedics Inc.’s Multidistrict Litigation, Pushing It to Sept. 24, Parker Waichman LLP Reports
5. The FDA is Pushing For Greater Restrictions on Prescription Painkillers: Now what?
6. Virtual boundaries: How environmental cues affect motivation and task-oriented behavior
7. A new European network crosses the boundaries for excellence in language and perception research
8. New drug prevents spread of human prostate cancer cells
9. Tiny hitchhikers attack cancer cells
10. To prevent leukemias dreaded return, go for the stem cells
11. Scientists identify major source of cells defense against oxidative stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... ... February 28, 2017 , ... The role of females ... from military to civilian life. Body image dissatisfaction is largely unexamined among female ... and greater occurrence of chronic mental health conditions than female civilians. Female veterans ...
(Date:2/27/2017)... ... February 27, 2017 , ... Robert E. Burke, MD, PhD, had a ... impoverished upbringing and life experiences could have led him down a much different path. ... Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a personal account of the ...
(Date:2/27/2017)... ... February 27, 2017 , ... Orange County dentist, ... inflammatory gum condition that occurs when the bacteria in plaque infect the gums and ... as a scaling and root planing or SRP, and can include surgical therapies if ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , is proud ... The new hire, Mackenzie Alsager, showcases the Centre's commitment to innovation in drug ...
(Date:2/26/2017)... ... 2017 , ... Today, A' Design Awards & Competition has ... Design Awards. , The 7th A' Social Design Award is open for ... with realized projects and conceptual works. , The first phase of the International ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... , Feb. 27, 2017 This report ... Teva and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since ... activity of one of the world,s leading life sciences ... upon purchase to ensure inclusion of the most up ...
(Date:2/27/2017)... The report "(CTMS)  Clinical Trial Management System Market ... Based), By Delivery Mode (Web, Cloud, On Premise), By End Use (Pharmaceutical ... Outlook (U.S., Canada , Germany , ... Russia , China , India ... , Taiwan , Brazil , ...
(Date:2/27/2017)... Feb. 27, 2017   Royal Philips ... global leader in health technology, today announced 510(k) ... (FDA) to market its ElastQ Imaging capability, further ... ultrasound systems. ElastQ Imaging enables simultaneous imaging of ... essential for the diagnosis of various liver conditions. ...
Breaking Medicine Technology: