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Published Results Using AtriCure Minimally Invasive Products

WEST CHESTER, Ohio, Oct. 16 /PRNewswire-FirstCall/ -- AtriCure, Inc. (Nasdaq: ATRC), a medical device company and leader in cardiac surgical ablation products, today announced that results reporting on the Company's proprietary minimally invasive products, which physicians have adopted to treat atrial fibrillation (AF), were published in the Journal of Cardiovascular Electrophysiology by Dr. James H. McClelland, an electrophysiologist, and colleagues from the Oregon Heart and Vascular Institute.

The authors reported the results from 20 AF patients. Based on the use of 30-day continuous monitoring at one-year follow-up, 87.5% of the paroxysmal and persistent AF patients and 75% of overall patients were free from AF and left atrial arrhythmias and were also off anti-arrhythmic drugs. There were no reports of major complications.

Dr. James H. McClelland commented, "These data suggest that epicardial bipolar ablation, along with guided ablation of the ganglionic plexi, is a promising potential treatment for patients with paroxysmal and persistent AF and a more extensive ablation treatment is likely required to treat patients with more permanent forms of AF."

"These results support our confidence in our ability to expand the treatment options for those patients who suffer from AF and our commitment to pursuing AF approvals for our products from the Food and Drug Administration (FDA)," said David J. Drachman, AtriCure's President and Chief Executive Officer. "During the first quarter of 2008, we have plans to investigate new products which will expand the ablation procedure. We believe that these new products will provide a superior treatment alternative for persistent and permanent AF patients, patients who fail catheter ablation procedures and patients who are at higher risk for strokes due to their AF."

About AtriCure, Inc.

AtriCure, Inc. is a medical device company focused on developing, manufacturing and selling innovative cardiac surgical devices designed to create precise lesions, or scars, in cardiac, or heart, tissues. Medical journals have described the adoption by leading cardiothoracic surgeons of the AtriCure Isolator(R) bipolar ablation clamps as a treatment alternative during open-heart surgical procedures to create lesions in cardiac tissue to block the abnormal electrical impulses that cause atrial fibrillation, or AF, a rapid, irregular quivering of the upper chambers of the heart. Additionally, leading cardiothoracic surgeons have described the AtriCure Isolator(R) clamps as a promising treatment alternative for patients who may be candidates for sole-therapy minimally invasive procedures. AF affects more than 2.5 million Americans and predisposes them to a five-fold increased risk of stroke.

The FDA has cleared the AtriCure Isolator(R) bipolar ablation system, including the new Isolator Synergy(TM) ablation clamps, for the ablation, or destruction, of soft tissues in general and cardiac related surgical procedures, but to date has not cleared or approved the system for the treatment of AF. The FDA has cleared the AtriCure multifunctional bipolar Pen for the ablation of cardiac tissue and for temporary pacing, sensing,

stimulating and recording during the evaluation of cardiac arrhythmias, but the multifunctional bipolar Pen has not been approved for the treatment of AF.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward- looking statements include statements that address activities, events or developments that AtriCure expects, believes or anticipates will or may occur in the future, such as earnings estimates, other predictions of financial performance, launches by AtriCure of new products and market acceptance of AtriCure's products. Forward-looking statements are based on AtriCure's experience and perception of current conditions, trends, expected future developments and other factors it believes are appropriate under the circumstances and are subject to numerous risks and uncertainties, many of which are beyond AtriCure's control. These risks and uncertainties include the rate and degree of market acceptance of AtriCure's products, AtriCure's ability to develop and market new and enhanced products, the timing of and ability to obtain and maintain regulatory clearances and approvals for its products, the timing of and ability to obtain reimbursement of procedures utilizing AtriCure's products, competition from existing and new products and procedures or AtriCure's ability to effectively react to other risks and uncertainties described from time to time in AtriCure's SEC filings, such as fluctuation of quarterly financial results, reliance on third party manufacturers and suppliers, litigation (including the purported class action lawsuit) or other proceedings, government regulation and stock price volatility. AtriCure does not guarantee any forward-looking statement, and actual results may differ materially from those projected. AtriCure undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.


AtriCure, Inc.

Julie A. Piton

Vice President and Chief Financial Officer

(513) 755-4561

SOURCE AtriCure, Inc.
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