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Psychiatric Drugs Might Raise Cardiac Death Risk
Date:5/14/2009

iac death were more likely to have taken one of three types.

Almost 11 percent of those who suffered sudden cardiac death took antipsychotics, compared to 1.4 percent of those who survived heart attacks. The numbers for antidepressants were 7.4 percent and 3 percent, respectively, and 18.4 percent and 5 percent for benzodiazepines, which include drugs such as Xanax.

Those who survived heart attacks were more likely to take aspirin and the heart drugs known as beta blockers.

The findings "are interesting, even provocative, but much more work remains to be done in order to have a high degree of confidence in the results," said Dr. Robert A. Harrington, director of the Duke Clinical Research Institute in Durham, N.C.

"For now, society should insist upon randomized clinical trials during and after the drug approval process that test therapies in patients who will likely take the drugs in 'real life,'" Harrington said.

That means those who take part in tests of drugs represent those who ultimately take them when it comes to their medical conditions and the other drugs that they're taking, he explained.

More information

Learn more about sudden cardiac death from the American Heart Association.



SOURCES: Jussi Honkola, M.D., researcher, University of Oulu, Finland; Robert A. Harrington, M.D., professor, medicine, Division of Cardiology, and director, Duke Clinical Research Institute, Durham, N.C.; May 14, 2009, presentation, Heart Rhythm Society annual meeting, Boston


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