Navigation Links
Prune juice not necessary: New research should make bowel movements easier
Date:4/8/2009

If you hate prune juice and chalky fiber supplements, just sit down and relax. Help is on the way. In a research report published online in The FASEB Journal (http://www.fasebj.org), a team of researchers has discovered a new way to make it a lot easier to go to the bathroom, especially when all other methods fail. Specifically, they have found a group of nerve ending receptors which, when stimulated, causes the bowels to pass waste, and the specific receptor needed to activate bowel clearance. Furthermore, they tested chemicals that work with those receptors, providing a blueprint for the development of new laxatives.

"We hope that the receptor identified by our study would be exploited more in the design of drugs to treat constipation," said Bindu Chandrasekharan, a researcher from Emory University who was involved in the study.

The research involved two groups of mice, focusing on a type of receptor also present on human nerves in the gut (a type of adenosine receptor). The first group of mice had normal adenosine receptors on these nerves and normal bowel movements. The second group of mice completely lacked these adenosine receptors and showed familiar signs of constipation. The researchers started with simple experiments such as comparing the wet weight, dry weight, and water content in the stools of both groups. The mice were also made to drink a dye not absorbed by the body to see how it passed or did not pass. In addition, the researchers used microscopic lasers to separate the nerve cells from the bowel to determine exactly where the receptors are located. Then they tested various chemicals that can activate or inhibit the nerve receptors.

"I actually like prune juice, but I find the study to be very compelling," said Gerald Weissmann, M.D, Editor-in-Chief of The FASEB Journal. "Here's why: First, we can look forward to a solution to what is sometimes a serious problem, especially infants and the elderly. Second, it's the first definitive proof that these receptors, the adenosine receptors, control bowel function. This discovery promises to yield agents that will permit us to sit down and ease up in the middle of a busy day."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. From Early Brain Development to Digestive Health, New Juicy Juice Beverages Aid Children Through Different Stages of Growth and Development
2. Diabetics May Soon Have Low-Sugar Vegetable Juice
3. CEO of iZO Cleanze Completes Day 50 of 100-Day Juice Cleanse
4. Precautionary Allergy Alert on Undeclared Milk Protein in Expired Codes of Broughton Foods Pints of Orange Juice, Citrus Punch, Fruit Punch and Iced Tea Products
5. ABC Releases Monograph on Scientific Research of POM Wonderful(R) Pomegranate Juice
6. Cranberry juice creates energy barrier that keeps bacteria away from cells, study shows
7. Nestle Juicy Juice Kicks Off Summer Promoting Nutritious, Active Lifestyle Choices Among Latino Children, Families
8. AVP Crocs Tour Announces Season-Long Contract With Naked Juice
9. Kagomes Yellow Mango Orchard Blended Juice Named One of Americas Healthiest Buys
10. Reported Health Benefits of Tart Cherry Boosts Juice Distribution in Southern U.S.
11. Fruit Juice May Be Healthy for Kids: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... ... Center for Autism and Related Disorders (CARD) Portland today announced plans to host ... other developmental disabilities. The group, which is being launched with the help of Robbie ... share stories and advice, seek help, and continue their education on how to best ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, a leading ... the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive years. The ... education, experience, and professional associations. , One the most frequently honored surgeons ...
(Date:12/2/2016)... Cleveland, OH (PRWEB) , ... December 02, 2016 ... ... provider of veterinarian diagnostic imaging systems and the first company to ... Robot With a Heart at their tradeshow booth # 941 for the American ...
(Date:12/2/2016)... ... 02, 2016 , ... Clarify Health Solutions, Inc., the leading ... in an initial round of funding. The round was led by experienced investors ... receive far better care through the application of the best technologies from other ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... ... to announce that we have been designated as a Cigna Infertility Center of ... exceed rigorous performance standards. , “It’s an honor to be designated a ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... - bioLytical lanza el INSTI HIV Self Test para el mercado ... Continue Reading ... New: INSTI Self Test! ... , bioLytical Laboratories (la "Compañía"), un líder mundial ... lanzamiento de su INSTI HIV Self Test  a África con una versión de ...
(Date:12/2/2016)... According to the latest market report published by ... Reprocessors: Single Basin Automated Endoscope Reprocessors Product Type Segment Anticipated ... the global automated endoscope reprocessors market was valued at US$ 740.6 Mn ... of 7.2% during an eight-year forecast period 2016-2024, to reach ... ...
(Date:12/2/2016)... , Dec. 2, 2016 In the ... sources apart from those derived from C. sativa, the ... Universita` di Napoli Federico II , the Universita` ... the first comprehensive, critical, integrated and unified inventory of ... article focuses on the remarkable chemical and structural ...
Breaking Medicine Technology: