Navigation Links
Prozac and Celexa exhibit anti-inflammatory effects
Date:2/24/2010

A new study found that fluoxetine (Prozac) and citalopram (Celexa) treatment significantly inhibited disease progression of collagen-induced arthritis (CIA) in mice. Research led by Sandra Sacre, Ph.D. from the Brighton and Sussex Medical School (BSMS) in the UK studied the anti-arthritic potential of these drugs, known as selective serotonin reuptake inhibitors (SSRIs), most commonly used to treat depression. Both SSRIs exhibited anti-inflammatory effects and may provide drug development opportunities for arthritic conditions such as rheumatoid arthritis (RA). Full findings of this study are published in the March issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.

RA is an autoimmune disease that causes inflammation in the lining of the joints. Typically, RA first affects hand and foot joints and later the disease spreads to larger joints. Inflammation eventually erodes the cartilage between the joints (articular cartilage) causing pain, stiffness, joint deformity, and physical disability. According to the 2000 Global Disease Burden study by the World Health Organization (WHO), RA affects approximately 1% of the world population.

To understand the anti-inflammatory properties of SSRIs, the research team at The Kennedy Institute of Rheumatology investigated the use of fluoxetine and citalopram in mouse and human models of RA. Dr Sacre, a lecturer in molecular cell biology at BSMS, a partnership between the universities of Brighton and Sussex, said: "We were interested in SSRIs because of their reported anti-inflammatory effects." "Prior studies have shown that patients with depression who respond to treatment with SSRIs display a reduction in cytokine levels (signals that can induce inflammation), suggesting a connection between SSRIs and the immune system."

In the current study, researchers used a CIA mouse model due to the similarities to human RA, including synovitis, bone erosion an
'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Prozac Makes Old Brain Cells Young
2. Prozac Reduces Disease Activity in MS Patients
3. Celexa May Not Help Kids With Autism
4. Milestone Scientific to Exhibit the STA(TM) System at the American Dental Associations 148th Annual Session in San Francisco
5. Worlds Largest Exhibit of Princess Dianas Dresses Hosted by Appleton Museum
6. Sesame Street Exhibition Makes Texas Premier at The Health Museum
7. CRH Medical to exhibit at American College of Surgeons Annual Clinical Congress
8. CareTech Solutions Executive to Conduct Presentation on Creating a Healthy Revenue Cycle at AHIMA Convention and Exhibit
9. Global Med Technologies(R), Inc.s Division, Wyndgate Technologies(R), to Exhibit at 60th Annual AABB Conference
10. Our Body: The Universe Within Exhibition Announces Four New Exhibits Across The Nation
11. Inovis Sponsors ASC X12 Conference, Exhibits BizManager and Secure Link
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Sir Fazle ... annual World Food Prize today. Sir Fazle has been recognised for his outstanding contribution ... , Ambassador Ken Quinn, President of the World Food Prize Foundation, announced this ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... announced that they will welcome four new members to their industry leading Scientific ...
(Date:7/1/2015)... ... July 01, 2015 , ... DIC Corporation today announced the ... natural blue food coloring. Construction of the plant, which is located on the ... began in May 2014. After commissioning, commercial production is expected to begin in ...
(Date:7/1/2015)... ... July 01, 2015 , ... OncLive® ... Hospital Corporation of America (HCA), as it further expands its Strategic Alliance Partnership ... , With this new partnership, OncLive’s editorial and marketing teams will collaborate with ...
(Date:7/1/2015)... ... ... The 28th annual Charity Horse Show hosted by the Mid-South Horse Show Association ... Pugh Bourne Park, 343 Oakfield Road. The event will again benefit Youth Town. , ... silent auction and concessions. , Horses and riders from around the country will participate ...
Breaking Medicine News(10 mins):Health News:Sir Fazle Hasan Abed Receives World Food Prize 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 2Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 4Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 5Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 2Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 3Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3
... taken gigantic proportions not only in the animal world but human ... wanting to visit // countries with bird flu like China, Vietnam, ... moment the unanimous voice is to take the plunge as bird ... to worry., ,The infection in humans is due to close ...
... to India for the sake of low priced cosmetic ... waistline, rhinoplasty, and breast improvements are very expensive. // ... UK every year. ,Recent figures released ... that breast enlargement topped the list of cosmetic operations ...
... beset with administrative problems, experienced another upheaval. In a ... // Dr. Hart, the Director of the program for ... Dr Hart will still continue as a full-time surgeon ... ,The UC San Diego, disappointed with the manner in ...
... A domino transplant surgery was conducted through which 3-month-old Jason ... week old baby received a heart // transplant in Ohio. ... passed away, and its organs were compatible to the two ... ,The dead child’s heart and lungs were transplanted to ...
... Canada has been warned of fines by the Government if ... Copeman Healthcare intends to establish clinics in Ottawa, Toronto, and ... charging a joining fee of $1,200, and another $2,300 towards ... ,The medicare law of the state says a fine of ...
... President George W. Bush as called for complete banning on ... as asked to reduce the medical // liability system; the ... among the American people which has reduced the number of ... talk as urged the congress to approve a complete ban ...
Cached Medicine News:Health News:More People Come To India For Cosmetic Surgery 2
(Date:7/1/2015)... , June 24, 2015 ... ) has announced the addition of the ... Chemistry and Immunodiagnostic Markets: Business Challenges, Emerging ... offering. 2015 New Frontiers in ... Challenges, Emerging Technologies, Competitive Landscape is a ...
(Date:7/1/2015)... SAN FRANCISCO , July 1, 2015 /PRNewswire/ ... study startup solutions, announced today unprecedented growth in ... "There is intense pressure to speed clinical trials ... protocols, globalization, and paper-based methods have stalled these ... "The current status of clinical trials has encouraged ...
(Date:7/1/2015)... 1, 2015  Echo Therapeutics, Inc. (NASDAQ: ... non-invasive continuous glucose monitoring and associated technologies, today ... re-designed corporate website echotx.com . Echo,s new ... technology and enhances the quality and availability of ... communicates to prospective customers and stakeholders what Echo ...
Breaking Medicine Technology:2015 New Frontiers in European Clinical Chemistry and Immunodiagnostic Markets: Business Challenges, Emerging Technologies, Competitive Landscape 2goBalto Triples Sites Managed, Further Reinforcing Market Leadership Position 2Echo Therapeutics Announces New Website Launch 2Echo Therapeutics Announces New Website Launch 3
... The Auto Suture™ VERSAPORT™ PLUS RPF trocar ... mm long, 5 mm-11 mm, 5 mm-12 mm, ... sleeve and shield. , ,The VERSAPORT™ PLUS ... a spring-loaded shield. Upon entry into a free ...
The SURGINEEDLE™ is a veress type needle that is used to insufflate the abdomen to create pneumoperitoneum....
... The complete line of Surgical Access ...unlike ... ,The OnePort™ trocar system is actually four ... versatile, operationally flexible and clinically adaptive to ... options in disposability and bladed or dilating ...
... The complete line of Surgical Access ...unlike ... ,The OnePort™ trocar system is actually four ... versatile, operationally flexible and clinically adaptive to ... options in disposability and bladed or dilating ...
Medicine Products: