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About AZILECT(R)

AZILECT(R) (rasagiline tablets) is indicated for the treatment of the signs and symptoms of Parkinson's disease both as initial therapy alone and to be added to levodopa later in the disease. The effectiveness of AZILECT was shown in patients with early PD who were receiving AZILECT as initial therapy alone and who were not receiving any other PD therapy. The effectiveness of AZILECT as adjunct therapy was shown in patients with PD who were treated with levodopa.

Important Safety Information:

-- Patients should not take AZILECT if they are currently taking

meperidine as it could possibly result in a serious reaction such as

coma or death.

-- Patients should not take AZILECT with tramadol, methadone,

propoxyphene, dextromethorphan, St. John's wort, mirtazapine, or

cyclobenzaprine.

-- Patients should not take AZILECT with other monoamine oxidase

inhibitors (MAOIs), amphetamines, cold remedies containing

decongestants and weight-reducing preparations containing

pseudoephedrine, phenylephrine, phenylpropanolamine, or ephedrine in

order to avoid a possibly dangerous increase in blood pressure.

Symptoms of this reaction include severe headache, blurred vision,

difficulty thinking, seizures, chest pain, unexplained nausea or

vomiting, or signs or symptoms of a stroke. Patients or caregivers

should seek immediate medical attention if these symptoms or other

unusual symptoms occur.

-- In order to prevent a possibly dangerous increase in blood pressure,

patients taking AZILECT should avoid foods and beverages high in

tyramine content such as aged cheeses, air-dried meats, pickled

herring, yeast extract, aged red wines, tap/draft beers, sauerkraut,

and soy sauce.

-- Patients taking A
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