Navigation Links
Prototype test for predicting clinical outcome for melanoma patients
Date:8/14/2008

enefit by comparing patients who receive the new therapy with those who do not. Although patients might all have the same type of cancers, there can be big differences in their survival simply because their cancers behave differently - and this may have nothing to do with the treatment. If we are able to identify the good players and the bad players up-front, it becomes a whole lot easier figuring out whether good results are due to the new treatment or not. Most importantly far fewer patients would be needed for the clinical trials. It's partly because we can't clinically identify subtypes of patients that we have to do very large and very expensive trials. And, of course, this increases the time it takes to test the clinical benefit of potential new therapies."

The joint Australian/New Zealand team used microarrays to measure the expression of more than 30,000 genes in lymph node sections taken from 29 patients with Stage III melanoma. There were 2,140 genes differentially expressed in the sections from people who had already had a "poor" outcome (average TTP of just four months) and patients that had had a "good" outcome (average TTP of 40+ months). Using statistical analyses, the team identified 21 genes that could be used to differentiate between the two subtypes of patients in the retrospective analysis. This gene signature was then used to prospectively analyze another 10 patients, with the clinical outcome for nine of the 10 (90%) patients proving to be predicted accurately. The one patient who was incorrectly predicted to have a "good" prognosis did have a rapid TTP to Stage IV. However, this patient went on to have a prolonged survival of six years. The team also applied the test to published data sets and showed they could get a prediction accuracy of 85%, event though data was not available for all 21 genes in the published literature.

This study was conducted under the auspices of the Hilton Ludwig Cancer Metastasis Initiative. It was
'/>"/>

Contact: Sarah L. White
swhite@licr.org
917-379-0398
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Intervention for Adults with Autism Spectrum Disorder Prototype Completed by SIMmersion LLC
2. STMicroelectronics and Debiotech Announce First Prototypes of Disposable Insulin Nanopump
3. Shopko Announces New Prototype Store in Council Bluffs
4. Research highlights problems of predicting birthweights in obese mothers
5. Predicting post-traumatic stress disorders in deployed veterans
6. Predicting the future in ovarian cancer
7. Predicting survival after liver transplantation
8. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
9. Use of certain lipid measures not more effective in predicting coronary heart disease
10. Analysis of Six Clinical Trials Finds EPZICOM(R) Effective in Treatment-Naive HIV Patients With Both High and Low Baseline Viral Loads
11. Clinical Research Management gets contract for trials of therapeutics against infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Today the Brain Injury Association of America (BIAA) ... recognize and support the more than 5.3 million Americans who ... leads the nation in observing Brain Injury Awareness Month by ... theme for the 2015 to 2017 campaign is: Not Alone. ... educating the general public about the incidence of brain injury ...
(Date:3/2/2015)... GBCHealth, a prominent business coalition ... activities and investments in global health issues, today ... members to serve on the organization’s Board of ... Strategist and Co-founder of Partners In Health, and ... Abbasi, General Manager of Global Health and Medical ...
(Date:3/2/2015)... Los Angeles, CA (PRWEB) March 02, 2015 ... Jimmy Buffett tickets at the Hollywood Bowl . This ... can add customer appreciation promo code JIMMY-BUFFETT-2015 for added ... celebrate because their favorite performer will be headlining at ... This concert will be on Thursday, October 22nd ...
(Date:3/2/2015)... FL (PRWEB) March 02, 2015 While ... with Title VI of the Civil Rights Act, the ... and hearing loss are bringing light to the value ... statistics reveal that nearly 1 in 20 U.S. children ... in 10 in some major cities.(1) Stratus Video ...
(Date:3/2/2015)... March 02, 2015 ZoomCare announced ... remake American healthcare. Zoom will expand its Portland ... clinics and advanced care studios delivering urgent care, ... services, specialty care and outpatient surgery. With its ... to almost all healthcare needs outside of hospitalization. ...
Breaking Medicine News(10 mins):Health News:Brain Injury Association of America Launches “Not Alone” Campaign for Brain Injury Awareness Month 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 3Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 4Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 5Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 3Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 4Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 2Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 3
... people in order to show- how eating patterns can stop you ... aged 60 or over living in many countries . They ... ate lots of green leafy vegetables, beans, olive oil, nuts and ... meat and sugar was also linked to keeping a smoother skin.// ...
... inhibitor ramipril, used for the treatment of hypertension, can ... thereby lowering the risk of stroke and myocardial infarction ... Heat Outcome Prevention Evaluation (HOPE) study showed the drug ... broad range of patients – those with normal or ...
... chronic bronchitis, research has found. It has been thought that ... survey of almost 16,000 people aged 18 to 47 ... opposite. ,The researchers found that the disease affects ... Young smokers were particularly at risk, and men were more ...
... occur in several forms, but systemic lupus erythematosus (SLE)--usually ... It is an incurable disease marked by inflammation and ... the joints, skin, heart, kidney and central nervous system. ... mistakenly attacks the body's own tissue. ,New research ...
... to believe that a gene-based treatment for heart disease may ... blood vessels in hearts with severe hardening of the arteries ... patients suffering with heart disease.// ,Treatment options for ... that open blocked arteries and improve blood flow to the ...
... A new study from Brazil has found that coffee ... blood levels of cholesterol and the protein homocysteine.High levels ... disease. Some of the compounds, called terpenoids, are known ... Right, of Marylandl University Hospital ,US, explained that "it ...
Cached Medicine News:Health News:New light on Cardiology 2
(Date:3/2/2015)... -- Edison Investment Research, a leading ... full coverage of Abzena  Highlights of ... biotech analysts Christian Glennie and Dr ... offers a range of key services and technologies ... biological products. Antitope (immunogenicity testing, protein engineering, cell ...
(Date:3/2/2015)... Mount Elizabeth Novena Hospital will soon become the first ... treat cancer using the TrueBeam™ STx system for radiotherapy ... VAR ).  At a Grand Opening event last Friday, ... of treatment including radiosurgery, a precise method of using ... from outside the body, without performing surgery.  ...
(Date:3/2/2015)... -- Valencia Technologies Corporation (" Valencia ") ... small device for the treatment of high blood pressure ... double-blinded, controlled trial are compelling and provide the Company ... succeed in a large U.S. trial for FDA approval. ... Valencia has successfully raised more than 2.2 ...
Breaking Medicine Technology:Edison Initiates Coverage on Abzena 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 3Valencia Technologies Implants its 48th Patient, Continues Equity Crowdfunding 2
... , RYE, N.Y., Nov. 19 Curemark LLC, ( ... focused on the treatment of neurological diseases, announced that the ... for CM-AT, its autism treatment, at three additional clinical trial ... Center in Phoenix, Arizona (SARRC); Pennsylvania State University,s Pediatric Clinical ...
... , PARIS, Nov. 19 Radiall and Integral ... medical applications, signing an agreement to confirm this new alliance. ... a long period of time, the company has established relationships ... OEMs supplying diagnostic equipment. , Integral Process is a ...
Cached Medicine Technology:Curemark Opens Patient Enrollment for Autism Treatment at Three More Clinical Trial Sites 2Curemark Opens Patient Enrollment for Autism Treatment at Three More Clinical Trial Sites 3Radiall and Integral Process Sign Agreement 2
... Trellis Infusion Catheter enables the physician to ... fluid, and disperse the agent by means ... Trellis is a multi-lumen catheter with two ... and infusion holes located between these balloons. ...
... OptiEdge offers design innovations that ensure outstanding ... handling. The biostable acrylic material of the ... the patented OptiEdge is designed to both ... of contact with the posterior capsule; and ...
... posterior chamber lenses are optical implants for ... in the visual correction of aphakia in ... The optical portion consists of a high ... have biconvex optics and supporting haptics of ...
... an intraocular lens that doesn't stop ... natural human lens, the new ACRYSOF® ... high-energy blue light. But while it ... your patient's view. That's just as ...
Medicine Products: