Navigation Links
Proton therapy may reduce serious side effect of lung cancer treatment

Patients with locally advanced lung cancer who receive chemotherapy and proton therapy, a specialized form a radiation therapy only available in a few centers in the United States, have fewer instances of a serious side effect called bone marrow toxicity than patients who receive chemotherapy and another type of radiation therapy called intensity modulated radiation therapy (IMRT), according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

The standard of care for patients with locally advanced non-small-cell lung cancer is chemotherapy and radiation therapy. Unfortunately, these aggressive treatments can put patients at risk of a serious side effect called bone marrow toxicity that can lead to delayed or missed treatments, hospitalizations and growth problems.

To try to alleviate this side effect, doctors at M.D. Anderson Cancer Center examined 142 patients with locally advanced non-small cell lung cancer. Of those, 75 patients received chemotherapy plus a type of targeted photon (X-ray) radiation therapy called intensity modulated radiation therapy (IMRT). The remaining 67 patients received chemotherapy and proton beam therapy. Proton beam therapy is a type of external beam therapy that uses protons rather than photons to kill fast growing cancer cells.

"Because proton therapy allows us to control the radiation differently than other types of external beam radiation therapy, we were hopeful that we could keep radiation away from critical structures, like the bones to avoid bone marrow toxicity," said Ritsuko Komaki, M.D., FASTRO, a radiation oncologist at M.D. Anderson Cancer Center in Houston.

After a follow-up time of 17 months, researchers found patients who received proton therapy with chemotherapy had a significant reduction in bone marrow toxicity compared to patients who received IMRT and chemotherapy. These findings suggest that using proton therapy over other types of radiation may allow doctors to give a higher dose of radiation without compromising the chemotherapy schedule to the lung tumor while avoiding some debilitating side effects, like bone marrow toxicity.

"These results are very promising for people with locally advanced lung cancer," said Dr. Komaki. "However, we need to now confirm these findings with a randomized trial."


Contact: Beth Bukata
American Society for Therapeutic Radiology and Oncology

Related medicine news :

1. Historic Agreement Reached to More Expertly and Efficiently Expand Proton Therapy Worldwide
2. Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension
3. Loma Linda University to Dedicate Proton Treatment Center to Cancer Therapy Pioneer James M. Slater, M.D.
4. Eclipse(TM) Proton Scanning Algorithm from Varian Medical Systems Receives FDA Clearance
5. Proton-powered pooping
6. Wyeth Announces Launch of Own Generic Version of PROTONIX
7. Caraco Pharmaceutical Laboratories Ltd. to Market Generic Protonix(R)
8. Seattle Cancer Care Alliance and Northwest Hospital Sign Letter of Intent to Develop Proton Therapy Center for Cancer Treatment
9. Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
10. Varian Medical Systems to Develop Interface Between the ARIA(TM) Oncology Information System and the Monarch250(TM) Proton Radiotherapy System From Still River Systems
11. LegalView Warns Proton Pump Inhibitor Patients of Potential Bone Fracture Risk Associated with Drug
Post Your Comments:
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: