Navigation Links
Protocol for a clinical study on reduced toxicant prototype cigarettes published
Date:7/28/2013

selected biomarkers. The protocol for this new study has been approved by an independent ethics committee and is published in BioMed Central Public Health.

The six-month single-centre, single-blinded, controlled switching study with periods of clinical confinement is being conducted in Germany. A total of 260 healthy adult subjects were recruited into the study; 140 smokers, 60 former smokers and 60 never-smokers (ISRCTN81286286). The demographically matched non-smokers serve as a comparison group because some toxicant exposure stems from dietary and environmental sources. The non-smokers also provide reference levels for biomarkers of biological effect.

Smokers are randomly assigned to a control or test group. Both groups smoke a control product for two weeks, at which point baseline measurements of biomarker levels are made. Smokers in the control group then continue to smoke the control product for a further 24 weeks, while smokers in the test group switch to the prototype cigarette. Urine, saliva and blood samples are taken from all smokers at 4, 9, 13 and 24 weeks after the switch. Biomarkers of exposure and biological effect are then measured.

Changes in biomarker levels are analysed at baseline, midpoint and end of the study. Levels within individuals are compared before and after switching, while those between individuals are evaluated by comparing smokers who switched with those who didn't.

Data from this study are expected to improve the scientific understanding of tobacco products. Changes in biomarkers of biological effect may add to the body of evidence of the potential of toxicant reducing technologies in reducing disease risk.

"There are already tobacco and nicotine products available, such as snus and e-cigarettes, that are known to pose substantially lower risk than cigarettes. And we don't know whether it will be possible to scientifically prove that reduced toxicant cigarettes reduce health risks,' said Dr David O'Reill
'/>"/>

Contact: Dr. Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New treatment protocol extends survival in some cases of once inoperable pancreatic cancer
2. Researchers develop secure protocol for linking data registries for HPV surveillance
3. ASTRO: Deviating from radiation protocols increases risk of treatment failure and death
4. Dr. Robbins Updates HCG EZ Drops Diet Protocols
5. Comprehensive maternal hemorrhage protocols improve patient safety
6. Delgado Protocol Announces Adrenal DMG, An Amazing New Supplement Designed to Support the Immune, Circulatory and Cardiovascular Systems
7. Standard CT protocol for trauma patients leads to overutilization of imaging
8. Audiology Associates Explains New Hearing Aid Protocol in Honor of Better Hearing and Speech Month
9. Delgado Protocol For Health Introduces Stay Young, A Powerful New Anti-Aging Supplement
10. Keller Family Dental Explains their Infection Control Protocols
11. PilotFish Expand’s Healthcare Integration Capabilities with Support for the New Direct Protocol in Its Latest Product Release
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Hay House is pleased to announce the ... Your Life (Paperback; $10.82) written by the highly esteemed Tommy ... This book is meant to help readers of all kinds ... , Recovery 2.0 is not the average self-help book, ... a guide for what comes next. For many, ...
(Date:10/22/2014)... October 22, 2014 Healthcare professionals ... their continuing education at home or on-the-go via ... to 20 brand new, premium Seminar-on-Demand CE courses. ... of over 2,000 hours of CE ... their educational experience. With such a diverse library, ...
(Date:10/22/2014)... Prussia, PA (PRWEB) October 22, 2014 ... recognized as an industry leader with over 25 years ... winning team leader in the areas related to EDI, ... Mr. Carlson is an Editorial Advisory Board member for ... Council Educator. Blue Fin Group is a management ...
(Date:10/22/2014)... -- Two sisters in high school have developed ways ... Medha Krishen use electronic stethoscopes, which electronically amplify body ... patterns or heartbeats. Ilina, a senior at Port ... a way to detect early lung damage in people ... Ilina recorded one breath cycle each from 16 smokers, ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, ... tightened guidelines for health workers treating Ebola patients, now requiring ... a respirator at all times. The U.S. Centers for ... after two Dallas nurses contracted Ebola while caring for the ... Thomas Eric Duncan. Nina Pham is currently being treated for ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
... HealthDay Reporter , WEDNESDAY, Oct. 19 (HealthDay News) ... an HIV patient tested positive for the bacterium that causes ... initial infection most likely occurred decades earlier, from exposure to ... infection, the Ohio man developed lesions on his skin that ...
... , WEDNESDAY, Oct. 19 (HealthDay News) -- The U.S. ... the quality of care it provides to mentally ill veterans, ... offered in various facilities across the country, according to a ... research organization, also noted that mental health services for veterans ...
... the University of North Carolina at Chapel Hill School of ... one of the nation,s highest honors for those in the ... Assad Meymandi Distinguished Professor and Chair of Psychiatry, is among ... (Oct. 17). Rubinow is an internationally recognized expert in ...
... - The National Institute on Disability and Rehabilitation Research ... researchers at Frazier Rehab Institute and the University of ... Spinal Cord Injury Model System. The grant is ... officials in making the announcement Oct. 19. "The ...
... and clinical investigators from the throughout the Middle East ... International Osteoporosis Foundation,s (IOF) 1st Middle-East and Africa Osteoporosis ... the Intercontinental Dubai Festival City to October 22, 2011,has ... Bin Rashid Al Maktoum, Deputy Ruler of Dubai, U.A.E. ...
... common belief, men age 75 and older are diagnosed with ... the disease more often than younger men, according to a ... journal, Cancer . , The study is particularly relevant ... Earlier this month a government health panel said that healthy ...
Cached Medicine News:Health News:U.S. Man Diagnosed With HIV Develops Leprosy 2Health News:U.S. Man Diagnosed With HIV Develops Leprosy 3Health News:Care for Mentally Ill Vets at VA Centers May Differ Across U.S. 2Health News:Care for Mentally Ill Vets at VA Centers May Differ Across U.S. 3Health News:Frazier Rehab, UofL earn $2.2 million grant for Spinal Cord Injury Model System 2Health News:Frazier Rehab, UofL earn $2.2 million grant for Spinal Cord Injury Model System 3Health News:1st Middle East and Africa Osteoporosis Meeting opens in Dubai 2Health News:Rochester study: Age a big factor in prostate cancer deaths 2
(Date:10/22/2014)...   BioNano Genomics , the genome mapping ... to purchase an Irys™ System . Among them ... (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope (The ... comprehensive view of a genome was a major ... deliver the scalability or reliability to detect and ...
(Date:10/22/2014)... Abaxis, Inc. (NasdaqGS: ABAX ), a medical ... financial results for the second fiscal quarter ended September ... Revenues of $53.9 million, up 18% over last year,s ... 33% over last year,s comparable quarter. Revenues ... Laboratories (AVRL) of $3.5 million, up 50% over last ...
(Date:10/22/2014)... 2014   Surefire Medical , Inc., the developer ... maximize targeted delivery of embolization agents in minimally invasive ... John R. Daniels , MD of the University ... oncologist Steven C. Katz , MD of the ... Advisory Board (SAB).    "The role of ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14Surefire Medical's Scientific Advisory Board Expands, Broadens Clinical Trial Expertise 2
... and SYDNEY, Nov. 11, 2010 HeartWare International, Inc. ... innovator of less invasive, miniaturized circulatory support technologies that ... announced that CEO Doug Godshall is scheduled to make ... Annual Healthcare Conference on Wednesday, November 17, at 1:15 ...
... 11, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first ...
Cached Medicine Technology:HeartWare to Present at the Lazard Capital Markets 7th Annual Healthcare Conference 2Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 2Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 3Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 4Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 5Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 6Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 7Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 8Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 9Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 10Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 11Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 12Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 13Transcept Pharmaceuticals Reports Third Quarter 2010 Financial Results 14
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: