Navigation Links
Protocol for a clinical study on reduced toxicant prototype cigarettes published
Date:7/28/2013

selected biomarkers. The protocol for this new study has been approved by an independent ethics committee and is published in BioMed Central Public Health.

The six-month single-centre, single-blinded, controlled switching study with periods of clinical confinement is being conducted in Germany. A total of 260 healthy adult subjects were recruited into the study; 140 smokers, 60 former smokers and 60 never-smokers (ISRCTN81286286). The demographically matched non-smokers serve as a comparison group because some toxicant exposure stems from dietary and environmental sources. The non-smokers also provide reference levels for biomarkers of biological effect.

Smokers are randomly assigned to a control or test group. Both groups smoke a control product for two weeks, at which point baseline measurements of biomarker levels are made. Smokers in the control group then continue to smoke the control product for a further 24 weeks, while smokers in the test group switch to the prototype cigarette. Urine, saliva and blood samples are taken from all smokers at 4, 9, 13 and 24 weeks after the switch. Biomarkers of exposure and biological effect are then measured.

Changes in biomarker levels are analysed at baseline, midpoint and end of the study. Levels within individuals are compared before and after switching, while those between individuals are evaluated by comparing smokers who switched with those who didn't.

Data from this study are expected to improve the scientific understanding of tobacco products. Changes in biomarkers of biological effect may add to the body of evidence of the potential of toxicant reducing technologies in reducing disease risk.

"There are already tobacco and nicotine products available, such as snus and e-cigarettes, that are known to pose substantially lower risk than cigarettes. And we don't know whether it will be possible to scientifically prove that reduced toxicant cigarettes reduce health risks,' said Dr David O'Reill
'/>"/>

Contact: Dr. Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New treatment protocol extends survival in some cases of once inoperable pancreatic cancer
2. Researchers develop secure protocol for linking data registries for HPV surveillance
3. ASTRO: Deviating from radiation protocols increases risk of treatment failure and death
4. Dr. Robbins Updates HCG EZ Drops Diet Protocols
5. Comprehensive maternal hemorrhage protocols improve patient safety
6. Delgado Protocol Announces Adrenal DMG, An Amazing New Supplement Designed to Support the Immune, Circulatory and Cardiovascular Systems
7. Standard CT protocol for trauma patients leads to overutilization of imaging
8. Audiology Associates Explains New Hearing Aid Protocol in Honor of Better Hearing and Speech Month
9. Delgado Protocol For Health Introduces Stay Young, A Powerful New Anti-Aging Supplement
10. Keller Family Dental Explains their Infection Control Protocols
11. PilotFish Expand’s Healthcare Integration Capabilities with Support for the New Direct Protocol in Its Latest Product Release
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Physicians in China are most eagerly awaiting a ... lymphoma (NHL), according to a new report from ... MabThera is the only biologic available to treat diffuse ... NHL. , According to Kantar Health’s report, “Biosimilars in ... in China has been growing and is expected to ...
(Date:12/22/2014)... Super Saturday, the last Saturday before ... the busiest day in the 2014 holiday shopping season. ... had a steady pre-Christmas stream of customers, ready to ... , “I definitely intend to take advantage…of the recreational ... who was enjoying The Grass Station’s holiday sale on ...
(Date:12/22/2014)... 22, 2014 Only weeks following the ... mid-western cities to have a battery manufacturer create 29 ... ( http://www.talklocal.com ) is launching in Henderson to ... , “A strong manufacturing sector is going to build ... Singh explained, “and TalkLocal works with small businesses that ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Pasadena ... offering consultations for sleep apnea. Drowsy drivers are 15 ... drivers who are well-rested, and some experts believe that ... roads as intoxicated drivers. Unfortunately, millions of Americans may ... American Academy of Sleep Medicine, about 18 million Americans ...
Breaking Medicine News(10 mins):Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2
... adolescents and young adults finds that an extensive set ... of asthma attacks in participants who both receive care ... This finding differs from previous reports suggesting that ... future asthma attacks. These earlier conclusions, however, were based ...
... of blocking the formation of specific protein clumps that ... been discovered by researchers at the University of Pennsylvania ... they have identified drug-like inhibitors of AD tau protein ... Co-authors Alex Crowe, Research Specialist; Kurt R. ...
... , , Campaign couples power ... , HARRISBURG, Pa., Aug. 10 /PRNewswire-USNewswire/ -- ... Health Action Now campaign with a multimillion-dollar national advertising and grassroots ... dependable, affordable health insurance. The Association,s paid advertising -- available ...
... , PITTSBURGH, Aug. 10 DynaVox Mayer-Johnson, ... for individuals with speech, language and learning disabilities, today ... standard for hand-held speech solutions by bringing together comprehensive ... of mainstream communication features. , , ...
... other contact sports, study finds , MONDAY, Aug. 10 (HealthDay ... about the same rate as in baseball and football, deaths ... common in lacrosse, new research shows. , Lacrosse has swept ... making it the fastest-growing youth sport in the country. The ...
... , , HUDSON, Mass., Aug. 10 ... provider of high performance interconnect solutions for the most ... series circular connectors were selected by SynCardia Systems, Inc. ... to provide critical interconnect reliability for their Freedom(TM) driver, ...
Cached Medicine News:Health News:NIAID media availability: Still searching for predictors of asthma attacks 2Health News:New class of compounds discovered for potential Alzheimer's disease drug 2Health News:New class of compounds discovered for potential Alzheimer's disease drug 3Health News:Multimillion-Dollar AARP Campaign Busts the Myths of the Health Care Debate 2Health News:Multimillion-Dollar AARP Campaign Busts the Myths of the Health Care Debate 3Health News:DynaVox Mayer-Johnson Announces the Xpress 2Health News:DynaVox Mayer-Johnson Announces the Xpress 3Health News:Blows to the Chest Up Death Risk for Lacrosse Players 2Health News:Blows to the Chest Up Death Risk for Lacrosse Players 3Health News:Hypertronics HyperGrip(R) and D Series Connectors Selected for SynCardia's Total Artificial Heart 2
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014 ... into expanded corporate offices in Aliso Viejo ... announced that due to the tremendous growth and worldwide ... needed. Sales of patented SnoreRx, the anti snore cure ... offices. He said, "We are now in 23 ...
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
(Date:12/22/2014)... 2014  Mark Farrah Associates (MFA), www.markfarrah.com ... of the 2015 marketplace exchange projections and insights ... According to a recent ASPE (Office of ... of Health and Human Services) report, an estimated ... plans through the Marketplace as of October 2014 ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Insights into the Marketplace and Individual Market Growth 2
... importance of dedicated information management systems for radiation ... most recent version of its MOSAIQ® Oncology Information ... Systems Society,s 2012 conference (HIMSS12), Feb. 20-24, in ... comprehensive OIS that centralizes traditional radiation oncology, particle ...
... Feb. 16, 2012  Cardium Therapeutics (NYSE Amex: ... previously announced sale of 17,857,143 shares of its common ... of approximately $5.0 million, before deducting placement agent,s fees ... investors participating in the offering purchased the shares at ...
Cached Medicine Technology:Elekta Highlights Latest Version of MOSAIQ Oncology Information System at HIMSS12 Meeting 2Cardium Announces Closing of $5.0 Million Equity Financing 2Cardium Announces Closing of $5.0 Million Equity Financing 3
Research Series 2100 Adjustable-volume Pipette,100-1,000 l, single-channel with adjustable-volume setting...
... first Sysmex hematology analyzer designed for a ... its small footprint, closed tube sampling, and ... of whole blood sample, you have a ... the emergency room, surgical suite, or small ...
... The Integrity family of pacemakers ... and truly automatic devices in today's ... combination of automated features and diagnostic ... popular and proven Affinity pacemakers platform. ...
... PT System is an in vitro diagnostic ... results, expressed in seconds and INR units. ... It is intended for use by health ... to monitor patients who are on warfarin-type ...
Medicine Products: