Navigation Links
Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
Date:1/14/2008

- by SELDI-TOF mass spectrometry, the investigators were able to identify an 11-protein signature that accurately discriminated between the cirrhosis and cancer patients, first in a training set (made up of 26 cirrhosis and 20 liver cancer patients), and then again in an independent validation set (consisting of 25 cirrhosis and 19 liver cancer patients). The resulting diagnostic value 74 percent sensitivity and 88 percent specificity compared favorably with the diagnostic accuracy of AFP (73 percent sensitivity and 71 percent specificity) as well as with two other biomarkers currently in clinical development for liver cancer, AFP-L3 and PIVKA-IL.

Most strikingly, notes Libermann, in patients with small tumors (less than 2 cm), where AFP identified only three, and AFP-L3 and PIVKA-II only one each, the 11-protein signature correctly identified seven of eight patients at this early stage of disease.

Biomarkers play a major role in all aspects of personalized medicine, not only in early disease detection, but also in outcome prediction and evaluation of therapeutic responses, he adds. This study provides strong evidence that serum contains early detection biomarkers and supports the notion that a combination of multiple biomarkers may prove more effective than individual biomarkers for diagnosis of liver cancer, as well as other cancers.


'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Story ideas from molecular & cellular proteomics
2. Genomic profiling of lung tumors helps doctors choose most effective treatment
3. Molecular profiling can accurately predict survival in colon cancer patients
4. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
5. Mayo Clinic to Pilot Collexis Expert Profiling
6. MammaPrint(R) Breast Cancer Test Shown To Be Powerful Tool for Prognosis Prediction in Postmenopausal Breast Cancer Patients
7. Once-Daily Exjade(R) Shown to Remove Toxic Iron From the Heart and Liver, According to Data Presented at ASH
8. Wild Blueberries Shown to Fight Oxidative Stress
9. Video game shown to cut cortisol
10. Breaking Study: Masimo Pleth Variability Index (PVI) Shown Effective in Noninvasive Detection of Changes in Ventricular Preload and Fluid Volume
11. Drug Detection Kits Manufactured By IDenta Corp. Shown During French Television Broadcast (at TF1) - Product Aids French Police In Bust of 600 Kilograms Of Cocaine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... CA (PRWEB) September 16, 2014 ... launch of two new product extensions, an accompanying ... headquarters, several novel marketing tools for their sales ... Vitamin Angels at their 5th annual national convention, ... room only crowd at the Hyatt Regency Orange ...
(Date:9/16/2014)... Recently, iFitDress.com, one of the most famous dress suppliers ... evening gown collection. According to the company’s sales manager, ... (up to 69% off) at present. Additionally, all the company’s ... am a frequent caller of your site. I like your ... feel quite happy. All items are of good quality. I ...
(Date:9/16/2014)... 2014 Today, Top10BestSEOHosting.com compares ... the USA and announces that HostMonster, Arvixe ... best Windows web hosting companies in the ... clients high quality WordPress hosting (including VPS ... , HostMonster provides outstanding customer support and ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Paradigm Physical ... offering a new therapeutic treatment for their patients. Dry ... to treat a variety of musculoskeletal problems. , In ... is inserted into the skin and muscle to create ... the needle, the needle helps to deactivate and release ...
(Date:9/16/2014)... September 16, 2014 Cliff Lake Dental Care ... Kristaleen is the newest dental hygienist to join Dr. Rauchwarter's ... to working with her and knows she will bring many ... , Kristaleen grew up in River Falls, WI. She ... College in 2003 and practiced dental assisting in the Twin ...
Breaking Medicine News(10 mins):Health News:New Products Announced at Jusuru International’s R2E14 National Convention 2Health News:New Products Announced at Jusuru International’s R2E14 National Convention 3Health News:New Products Announced at Jusuru International’s R2E14 National Convention 4Health News:iFitDress.com: One Shoulder Evening Gown Collection Unveiled Online 2Health News:Best Windows Web Hosting Suppliers Recommended By SEO Hosting Review Site Top10BestSEOHosting.com 2Health News:Paradigm Physical Therapy Introduces Dry Needling 2Health News:Cliff Lake Dental Care Announces Newest Team Member 2
... Data Shows a Comprehensive Technology Infrastructure Improves Efficiency, ... March 10 Two Kaiser Permanente studies published ... a comprehensive electronic health record can increase consumer ... clinical quality and that connecting patients directly with ...
... More physician leaders are embracing technological advances, such as ... and unresponsive to their needs.Those are the results found ... Physician Executives (ACPE). The findings were published in the ... of medical management.ACPE conducted the same survey back in ...
... N.Y., March 10 NBTY, Inc. (NYSE: ... and marketer of nutritional supplements, today announced that it ... Chief Financial Officer of NBTY, at the B. Riley ... Wednesday, March 18, 2009.The presentation is scheduled to be ...
... Adjusted FIFO EBITDA Increases 4.3% to $26.1 Million, Excluding ... Full Year Adjusted FIFO EBITDA Increases 15% to $90.5 ... Net Cash Provided by Operating Activities Increases 130% to ... Million and Full Year Net Loss of $72.8 Million ...
... in corrective surgery operations from 2007 and 2008. ... is breast augmentations (breast enlargements), tummy tucks and ... largest cosmetic surgeons in the UK, can reveal ... cosmetic procedures, with the figure worryingly increasing to ...
... Holdings Ltd,("Obio"/ "the Company") announced the discovery of a ... influenza virus (including avian and human,influenza strains) such as ... TG21 has already commenced. , ... in USA and,China to conduct various researches, all of ...
Cached Medicine News:Health News:Kaiser Permanente Identifies Key Elements in Successful Health Care Information Technology Implementation 2Health News:Kaiser Permanente Identifies Key Elements in Successful Health Care Information Technology Implementation 3Health News:Kaiser Permanente Identifies Key Elements in Successful Health Care Information Technology Implementation 4Health News:Survey Results: Health Care Technology Advances as Physician Frustration Grows 2Health News:NBTY to Webcast Presentation at B. Riley & Co. Annual Las Vegas Institutional Investor Conference; Announces Preliminary Unaudited Net Sales Results for February 2009 2Health News:NBTY to Webcast Presentation at B. Riley & Co. Annual Las Vegas Institutional Investor Conference; Announces Preliminary Unaudited Net Sales Results for February 2009 3Health News:NBTY to Webcast Presentation at B. Riley & Co. Annual Las Vegas Institutional Investor Conference; Announces Preliminary Unaudited Net Sales Results for February 2009 4Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 2Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 3Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 4Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 5Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 6Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 7Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 8Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 9Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 10Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 11Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 12Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 13Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 14Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 15Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 16Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 17Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 18Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 19Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 20Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 21Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 22Health News:Duane Reade Holdings, Inc. Reports Fourth Quarter and Full Year 2008 Results 23Health News:Brits Love Affair with Holiday Cosmetic Surgery Creates Increase in UK Corrective Surgery 2Health News:Brits Love Affair with Holiday Cosmetic Surgery Creates Increase in UK Corrective Surgery 3Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 2Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 3
(Date:9/16/2014)... -- Endo International plc (NASDAQ: ENDP ) (TSX: ... acquire all of the outstanding shares of Auxilium Pharmaceuticals, Inc. ... of $28.10 in a cash and stock transaction valued at ... 31% to Auxilium,s closing price on September 16, 2014 and ... shares for the previous 30 days.  Under the terms of ...
(Date:9/16/2014)... YORK , Sept. 16, 2014  This report analyzes ... Units, The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... , and Rest of World. Annual estimates and forecasts ... seven-year historic analysis is provided for these markets. Market data ...
(Date:9/16/2014)... , Sept. 16, 2014 Adaptive Biotechnologies, a ... (NGS) to profile the adaptive immune system, is pleased ... as Chief Commercial Officer (CCO). The addition of Brain ... key hires from leading global healthcare companies, including ... (General Counsel) from Genomic Health and Sean Nolan ...
Breaking Medicine Technology:Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 2Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 3Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 4Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 5Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 6Endo Delivers A Proposal To Acquire Auxilium Pharmaceuticals For $28.10 Per Share In Cash And Stock 7Global Digital Radiography Industry 2Global Digital Radiography Industry 3Global Digital Radiography Industry 4Global Digital Radiography Industry 5Global Digital Radiography Industry 6Global Digital Radiography Industry 7Global Digital Radiography Industry 8Global Digital Radiography Industry 9Global Digital Radiography Industry 10Global Digital Radiography Industry 11Global Digital Radiography Industry 12Global Digital Radiography Industry 13Global Digital Radiography Industry 14Global Digital Radiography Industry 15Global Digital Radiography Industry 16Global Digital Radiography Industry 17Global Digital Radiography Industry 18Global Digital Radiography Industry 19Global Digital Radiography Industry 20Global Digital Radiography Industry 21Global Digital Radiography Industry 22Veteran Genoptix and Gen-Probe Executive, Brian Hansen, joins Adaptive Biotechnologies as Chief Commercial Officer 2Veteran Genoptix and Gen-Probe Executive, Brian Hansen, joins Adaptive Biotechnologies as Chief Commercial Officer 3
... intended for the immunochromatographic, qualitative determination ... Strip Gonorrhea is based on the ... determination of gonorrhea antigen in the ... system as an aid in the ...
The IntraStent DoubleStrut Biliary Stent represents a completely new direction in stent design. The combination of parallel struts and unique cell geometry provide unparalleled performance....
The Smart Check Syphilis Device is a qualitative membrane device based immunoassay for the detection of TP (Treponema Pallidum) antibodies in whole blood/serum/plasma. For professional in vitro diagn...
Bio-Quant, Inc. OneStep hCG InstaTest is an immunochromatographic assay designed for qualitative determination of human chorionic gonadotropin (hCG) in urine for early detection of pregnancy....
Medicine Products: