Navigation Links
Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
Date:1/14/2008

al School. And a significant number of hepatitis C-infected patients will go on to develop liver cirrhosis. Cirrhosis results when healthy tissue is replaced by scar tissue, preventing the liver from properly functioning. Cirrhosis itself is responsible for more than 25,000 deaths each year. But, adds Afdhal, secondarily, cirrhosis greatly increases a persons chances of developing liver cancer.

Each year, cirrhosis patients have a two to five percent chance that their condition will escalate to cancer, he explains. And the problem is that, right now, there is no reliable means of detecting liver cancer at an early stage, when surgical treatment is an option. Typically by the time the disease is discovered, the cancer has advanced and treatment options become much more limited.

The best hope for early detection is cancer biomarkers, serum proteins found in altered amounts in blood or other body fluids. The current biomarker for liver cancer in clinical use is alpha fetoprotein (AFP). In many cases, patients with hepatitis C undergo routine monitoring for AFP levels as an indicator of whether tumors may have developed in their livers.

But, as Libermann explains, the AFP biomarker has a number of shortcomings, including false positives and false negatives. AFP not only fails to detect many early tumors, but it also lacks specificity. Consequently, elevated AFP levels could be indicators of not only cancer, but also of other liver diseases or even benign conditions, while on the other hand, many patients with small tumors will test negative for AFP.

The authors, therefore, decided to evaluate the sensitivy and specificity of SELDI-TOF MS for the detection of liver cancer and to compare its effectiveness with AFP.

Examining serum samples of 92 patients including 51 patients with liver cirrhosis and 41 patients with liver cancer, and among the cancer patients, individuals with both large and small (less than 2 cm) tumors -
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Story ideas from molecular & cellular proteomics
2. Genomic profiling of lung tumors helps doctors choose most effective treatment
3. Molecular profiling can accurately predict survival in colon cancer patients
4. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
5. Mayo Clinic to Pilot Collexis Expert Profiling
6. MammaPrint(R) Breast Cancer Test Shown To Be Powerful Tool for Prognosis Prediction in Postmenopausal Breast Cancer Patients
7. Once-Daily Exjade(R) Shown to Remove Toxic Iron From the Heart and Liver, According to Data Presented at ASH
8. Wild Blueberries Shown to Fight Oxidative Stress
9. Video game shown to cut cortisol
10. Breaking Study: Masimo Pleth Variability Index (PVI) Shown Effective in Noninvasive Detection of Changes in Ventricular Preload and Fluid Volume
11. Drug Detection Kits Manufactured By IDenta Corp. Shown During French Television Broadcast (at TF1) - Product Aids French Police In Bust of 600 Kilograms Of Cocaine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/7/2009)...Jan. 7 Eli Lilly and Com...esults for the fourth quarter and,full year of 20... conduct a,conference call on that day with the i...he company,s financial performance. , The c...0 a.m. EST.,Investors, media and the general publ...
(Date:1/7/2009)...s Seek Quality Online Tools , To Manage Family,s...eral Dentistry Creates Comprehensive Web Portal ,... Everyone knows that Moms are the ones who make mo...s no wonder that, when it comes to a family,s over...t." But until now, busy Moms were not sure where ...
(Date:1/7/2009)... seem to be as susceptible, study suggests , ...ge girls who spend more than two hours of "screen ...essaging are less likely to be physically fit, a n...s who were part of the same study were more likely...Louise Hardy, a postdoctoral fellow at the New Sou...
(Date:1/7/2009)...International Chronic Total Occlusion (CTO) Summit...t technologies, research findings and new developm...for interventional cardiologists to optimize proce.... The conference will include presentations from e...erous thematically organized live coronary CTO cas...
Breaking Medicine News(10 mins):Health News:KnowYourTeeth.com Launches as the Internet's New Go-To Resource for 'All Things Dental' 2Health News:KnowYourTeeth.com Launches as the Internet's New Go-To Resource for 'All Things Dental' 3Health News:KnowYourTeeth.com Launches as the Internet's New Go-To Resource for 'All Things Dental' 4Health News:KnowYourTeeth.com Launches as the Internet's New Go-To Resource for 'All Things Dental' 5Health News:More 'Screen Time' Linked to Poor Fitness in Girls 2
...asy. They live longer than almost anyone in the re...en vaccinated, and such scourges of the poor as pa...on-existent. Anyone can see a doctor, at low cost,... of the Cuban health care system is indeed stupend...
... announced today that it received approval from th... for the marketing of Divigel(R) (estradiol gel) 0... dose of estradiol available for the treatment of ...iated with menopause. "Divigel(R) provides a valua...
... does not advocate more power, freedom or equal so...endary skincare queen has inspired a legion of you...independence in a culture that for millennia has p... Beauty (NB)' cosmetics and skincare empire, which...
... rebelled Wednesday against threats from the churc...turning a ban on therapeutic cloning . One Cathol...th Wales state parliament said he would rather go ...how to vote from Sydney Catholic Archbishop George...
Other Medicine News:Health News:Cuba is Exporting Healthcare Now 2Health News:Cuba is Exporting Healthcare Now 3Health News:Cuba is Exporting Healthcare Now 4Health News:Cuba is Exporting Healthcare Now 5Health News:FDA Approves Divigel(R) for Treatment of Hot Flashes Linked With Menopause 2Health News:FDA Approves Divigel(R) for Treatment of Hot Flashes Linked With Menopause 3Health News:Taiwan Skincare Empire Built on 'Natural Beauty' 2Health News:Taiwan Skincare Empire Built on 'Natural Beauty' 3Health News:Australian Catholics Rebel Over Stem Cell Vote Warning 2
(Date:12/30/2008)...ewswire/ -- The Coalition for 21st Century Medicin...enentech, Inc. on December 5, 2008, seeking to res...tic tests to physicians and patients. The request...arm patient care and rests on flawed scientific an...s to encourage the research, development, and comm...
(Date:12/17/2008)...t and validation of non-animal alternative test me...re/ -- MatTek Corporation today announced that the...ed the scientific validity of the Modified EpiDerm...g. ESAC concluded that the Modified EpiDerm SIT h...diction of skin irritating and non-irritating test...
(Date:12/17/2008)...l/ -- Delcath Systems, Inc. (Nasdaq: DCTH ) toda...h.D., to Delcath,s Board of Directors. Dr. Contag...perience working with international and domestic i....com/cgi-bin/prnh/20081118/NY46990LOGO ) , ,... 2006 and served as CEO. Prior to starting Cobalt...
(Date:12/16/2008)...wswire/ -- Publication of a Canadian study on colo...uggests a lower impact on mortality than previousl...llege of Gastroenterology urge patients and the pu... design of this case-control study have produced a...le option for detection of precancerous colon poly...
Breaking Medicine Technology:Coalition for 21st Century Medicine Issues Statement in Opposition of Genentech Petition to Restrict Lab Use of Diagnostic Tests for Physicians and Patients 2Coalition for 21st Century Medicine Issues Statement in Opposition of Genentech Petition to Restrict Lab Use of Diagnostic Tests for Physicians and Patients 3Coalition for 21st Century Medicine Issues Statement in Opposition of Genentech Petition to Restrict Lab Use of Diagnostic Tests for Physicians and Patients 4EpiDerm's Skin Irritation Test Fully Validated in European Union 2Delcath Adds Dr. Pamela R. Contag to Its Board of Directors 2Delcath Adds Dr. Pamela R. Contag to Its Board of Directors 3Quality Colonoscopy Exam Remains Best Strategy for Detection of Polyps and Cancers According to Experts From the American College of Gastroenterology 2Hepatitis C Testing Recommended for Anyone with a Tattoo 4176 1Hepatitis C Testing Recommended for Anyone with a Tattoo 4176 2TriWest Contributes 2425 000 to Iowa National Guard Fund and Sponsors Education for Teachers of Military Children 4173 1TriWest Contributes 2425 000 to Iowa National Guard Fund and Sponsors Education for Teachers of Military Children 4173 2STERIS Corporation Announces Date of Fiscal 2008 Second Quarter Earnings Release and Conference Call 4170 1STERIS Corporation Announces Date of Fiscal 2008 Second Quarter Earnings Release and Conference Call 4170 2STERIS Corporation Announces Date of Fiscal 2008 Second Quarter Earnings Release and Conference Call 4170 3ARIUS to present at Chinese Global Financial Forum 1384 1ARIUS to present at Chinese Global Financial Forum 1384 2
...ping with the recent proliferation of rapid, easy-...n products have entered the marketplace to help cl...tic drugs and to screen for the presence of drugs ...y support while many simple test kits are suitable... for, home and workplace use. , , Therapeutic ...
...stein Barr virus (EBV), which causes infectious mo...viruses. EBV occurs worldwide, and most people bec... In the United States, as many as 95 percent of ad...cted. In most developed countries, including the U...dolescence or young adulthood, causing infectious ...
Other Medicine Technology:Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse 2Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse 3Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse 4Rapid Whole Blood Testing for Infectious Mononucleosis Antibodies 2Rapid Whole Blood Testing for Infectious Mononucleosis Antibodies 3
Renu effervescent enzymatic cleaner is an odorless tablet that removes protein deposits from daily and extended wear soft contact lenses in as little as 15 minutes. Renu effervescent enzymatic cleane
...instruments have been designed to provide the opht...requiring precise hemostasis. Medtronic recently i...r, diathermy instruments. These instruments provid...p hemostasis or controlled drainage retinotomy, wi...
...instruments have been designed to provide the opht...requiring precise hemostasis. Medtronic recently i...r, diathermy instruments. These instruments provid...p hemostasis or controlled drainage retinotomy, wi...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 5/box.
Medicine Products: