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Proteolix Announces the Appointment of John Scarlett, M.D., President and CEO
Date:2/25/2009

SOUTH SAN FRANCISCO, Calif., Feb. 25 /PRNewswire/ -- Proteolix, Inc., a leader in the discovery and development of novel therapeutics that target protein degradation pathways in cancer and autoimmune diseases, today announced the appointment of John A. Scarlett, M.D., to the position of President and Chief Executive Officer. Dr. Scarlett brings nearly 30 years of experience in drug development and commercialization to his new role. Susan Molineaux, Ph.D., who founded Proteolix in 2003, will transition from her position as Chief Executive Officer to serve as the company's Chief Scientific Officer.

"I am pleased to join the outstanding team at Proteolix, whose efforts have resulted in the discovery of the company's lead anticancer product, the proteasome inhibitor carfilzomib, for the treatment of multiple myeloma and other cancers," said Dr. Scarlett. "In particular, I am excited by the opportunity to oversee the advancement of carfilzomib, which has shown compelling single agent activity in several Phase 2 trials in multiple myeloma, through the final stages of clinical testing and into commercialization."

"I welcome Dr. Scarlett, whose extensive clinical and commercial experience will serve as an important asset to the company as carfilzomib advances through late-stage trials," stated Dr. Molineaux. "Proteolix has been successful in discovering and developing several inhibitors that selectively target the proteasome in new ways, which has allowed us to develop effective therapies for the treatment of both cancer and autoimmune diseases. I am proud of the progress our team has achieved to date and look forward to our continued successes."

On behalf of the Company's Board of Directors, Chairman Paul Hastings commented, "Proteolix has made remarkable strides under the leadership of Susan Molineaux in taking carfilzomib all the way from discovery through to successful Phase 2 clinical trials in a short pe
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SOURCE Proteolix, Inc.
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