Navigation Links
Proteins used to map the aging process
Date:6/19/2011

Loss of muscle mass is not only associated with disease, such as HIV and cancer, but also with the normal aging process. Anabolic steroids are sometimes used to reverse loss of lean muscle tissue but they can have unwanted side effects. New research, published in BioMed Central's open access journal Immunity and Aging, shows that nine proteins, isolated from blood, alter with age and that the profile of some of these proteins can be reversed by testosterone treatment.

In a combined study, researchers from Boston University School of Medicine and University of Texas Medical Branch compared protein levels in serum samples from two groups of healthy men - young men aged 18-35 and older men aged 60-75. Seven proteins, which were either growth factors (IGF-1, IL-7, IL-12p40, PDGFβ), or were involved in immune response (ENA78, MIP-1β, IP-10), and pro-collagen (PIIINP) were all reduced in older men. In contrast the monokine MIG, also involved in immune activity, was elevated.

Testosterone treatment increased lean muscle mass, and levels of the appetite suppressing hormone leptin, for both groups of men. Testosterone also increased levels of PIIINP and IGF-1 in young men and the researchers saw a similar increase in a small group of older men.

Dr Monty Montano said, "The blood proteins we found that altered with healthy aging also have links to maintenance of muscle, such as IGF-1 and pro-collagen, or are involved in regulation of the immune system, possibly reducing T-cell and neutrophil responses with age. Additionally all of the proteins we found are involved with the signaling pathways controlled by AKT, NFκβ and TGFβ which are known to be associated with aging."

Dr Montano continued, "It is no simple matter to find a one size fits all test for aging our results suggest that there is a difference in response to anabolic steroids between young and older men, despite both groups increasing in muscle mass. It seems that testosterone replacement does not necessarily mean a restoration of full testosterone functionality for the older man."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related medicine news :

1. SIBLING proteins may predict oral cancer
2. Proteins May Predict Spread of Colon Cancer
3. Proteins may point to alcohol use test
4. Newly identified proteins critical to FA pathway DNA repair function
5. Proteins in unroasted coffee beans may become next-generation insecticides
6. UD team develops new method for producing proteins critical to medical research
7. US Whey Proteins Market to Reach 472.3 Million Pounds by 2015, According to New Report by Global Industry Analysts, Inc.
8. Expression of certain transporter proteins may predict resistance to drug therapy
9. Hydrophobic proteins: Potential biomarkers for colorectal cancer
10. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
11. Misfolded neural proteins linked to autism disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... ... now promoting to the US market its advanced highly customizable contact technology solutions. ... ODU TURNTAC®. These advanced technologies are ideal for a wide range of applications ...
(Date:12/7/2016)... ... December 07, 2016 , ... Baciocco Brothers Insurance ... residents in the Sacramento/Folsom region, is initiating a charity event to raise support ... Choice Another Chance treatment center in Sacramento works to provide area teens and ...
(Date:12/7/2016)... ... ... One of two inventors from Glen Burnie, Md., has a granddaughter who ... is why the co-inventor and I have designed a new and better way to ... of the patent-pending AV-AIR, a device that serves as an alternative to conventional methods ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... A. Kevin ... owners and families throughout the Five Boroughs, is launching a charity drive to raise ... to continue the traditions and spirit of marines and Navy FMF Corpsmen. Working closely ...
(Date:12/7/2016)... ... December 07, 2016 , ... Sharon Kleyne, host of the ... and Your Health on Voice of America, declared on her radio program in November ... the fact that when these bullies attack leaders in corporate America, they are trying ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 2016  Palatin Technologies, Inc. ("Palatin") (NYSE MKT: ... previously disclosed underwritten public offering of units with ... sole book-running manager, Roth Capital Partners acted as ... co-manager for the offering. "This financing ... proceeds, allowing us to continue advancing bremelanotide for ...
(Date:12/7/2016)... Md. , Dec. 7, 2016  Northwest ... or the "Company"), a biotechnology company developing DCVax® ... announced that the Nasdaq Staff has not accepted ... of Listing Rules previously reported, and the Company ... withdraw the Company,s common stock from listing on ...
(Date:12/7/2016)... , December 7, 2016 ... Trial Management System (CTMS) Market, by Components (Software, ... Site), End-users (Pharmaceutical and Biotechnology Companies, Clinical Research ... Share, Size and Forecast to 2022", published by ... system (CTMS) market is expected to grow at ...
Breaking Medicine Technology: