Navigation Links
Proteins in migration
Date:5/24/2013

This news release is available in German.

In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mechanism underlying this pathological progression is poorly understood but could result from spreading of the protein (or abnormal forms of it) along nerve projections connecting lower to upper brain regions. Scientists at the German Center for Neurodegenerative Diseases (DZNE) in Bonn have developed a novel experimental model that reproduces for the first time this pattern of alpha-synuclein brain spreading and provides important clues on the mechanisms underlying this pathological process. They triggered the production of human alpha-synuclein in the lower rat brain and were able to trace the spreading of this protein toward higher brain regions. The new experimental paradigm could promote the development of ways to halt or slow down disease development in humans. The research team headed by Prof. Donato Di Monte presents these results in the scientific journal "EMBO Molecular Medicine".

Parkinson's disease is a disorder of the nervous system. It typically manifests itself with motor disturbances, such as an uncontrollable trembling of the limbs, as well as non-motor symptoms, including sleep disorders and depression.

At the present, no cure exists for Parkinson's disease, although symptomatic intervention, including treatment with dopamine agonists, can alleviate patients' motor impairment. Parkinson's is the second most common neurodegenerative disorder, after Alzheimer's disease; it is estimated that 100,000 to 300,000 patients are affected by Parkinson's disease in Germany alone.

In a small percentage of
'/>"/>

Contact: Marcus Neitzert
marcus.neitzert@dzne.de
49-228-433-02271
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
3. Overexpression of proteins 14-3-3 related to chemotherapy resistance
4. The key (proteins) to self-renewing skin
5. Regulation by proteins outside cancer cells points to potential new drug target
6. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
7. New regulatory mechanism discovered in cell system for eliminating unneeded proteins
8. Enzymes implicated in disease processes attack one another instead of harming body proteins
9. Toward medicines that recruit the bodys natural disease-fighting proteins
10. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
11. G proteins regulate remodelling of blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... England (PRWEB) December 26, 2014 The ... take place March 24-28, 2015 in Rome, Italy and ... line-up includes workshops on a wide variety ... as well as peak performance training in athletes. The ... around the world. , Biofeedback monitoring allows clients to ...
(Date:12/26/2014)... Pentec Health, Inc. number fourteen on the ... for 2014. The awards program, created in 2000, is ... in the country. The program is a public/private partnership ... and Economic Development, the Pennsylvania State Council of the ... Business Journal. , Charlie Wilson, Vice President ...
(Date:12/25/2014)... December 26, 2014 This is a ... the global Sterilizers industry with a focus on the ... market status of the Sterilizers manufacturers and is a ... individuals interested in the industry. This report provides a ... and manufacturing technology. In this part, the report presents ...
(Date:12/25/2014)... December 25, 2014 Product liability lawsuits ... hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward ... an Order issued in the U.S. District Court, Northern ... convene an open conference on January 7, 2015, at ... Courthouse in West Palm Beach, Florida. The Conference is ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
Breaking Medicine News(10 mins):Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3
... help decrease the risk of breast cancer in postmenopausal women. ... ages 50 and 79 years old. The women were assessed ... on how many hours per week they exercised. The level ... 50 years was also considered. Researchers documented cases of breast ...
... group of cells, called satellite cells, that line the ... // their youthfulness. These cells rescue damaged muscles and ... new cells for future repairs. Previous studies have shown ... is activated by another protein called Delta. ,Researchers ...
... study reports the vessels in the eyes may be ... appears to narrow before blood // pressure exceeds normal ... to photograph the retinas of more than 3,500 people. ... Researchers also measured the blood pressure of the patients ...
... New research shows heart attacks without chest pain are more ... heart attack. Instead of chest pain //, some patients experience ... and vomiting. ,Researchers conducted a study to see how ... treated and how they recover. The study included information on ...
... new research chemotherapy after surgery may not be better ... cancer patients. // However, researchers say, the study looked ... new chemotherapy regimens may be better. ,In 1977, ... after surgery was initiated. More than 1,000 patients with ...
... Researchers have now found a way to genetically engineer the ... leaving healthy ones intact.// They did this by modifying one ... they had to boost the activity of another gene to ... Specialists say, “When the virus infects cells, it takes the ...
Cached Medicine News:
(Date:12/24/2014)... -- The International Trade Commission (ITC) issued its final decision in ... a notice issued on December 23, the ITC ruled in ... humidifier was invalid. BMC President, James Xu ... excited with the ITC,s decision in this case. This victory ... the very beginning on the key patents in the case. ...
(Date:12/24/2014)... FARMINGTON, Conn. , Dec. 24, 2014 ... a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics ... medical need and commercial potential, today announced that ... 2,050,000 shares of its common stock and Series ... common stock.  Funds under the management of QVT ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... the equivalent of 7.5 liters out of your ... need two machines for your high-flow patients! , ... Oxygen-Conserving Devices function like standard conservers, because they ... oxygen required to saturate a patient. However, ...
Proven and Efficient Stand-Alone Device. International Model. 50 psi....
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
... ,Offers an average 5:1 increase in usage time ... of a standard cannula. , ,The combination ... ambulatory oxygen patients a superior alternative to liquid ... warranty. , ,NOTE: ...
Medicine Products: